Emerging strategies in lymph node-targeted nano-delivery systems for tumor immunotherapy

Essays in Biochemistry, Journal Year: 2025, Volume and Issue: 69(02)

Published: March 28, 2025

The emergence of immunotherapy has led to the clinical approval several related drugs. However, their efficacy against solid tumors remains limited. As hub immune activation, lymph nodes (LNs) play a critical role in tumor by initiating and amplifying responses. Nevertheless, intricate physiological structure barriers within LNs, combined with immunosuppressive microenvironment induced cells, significantly impede therapeutic immunotherapy. Engineered nanoparticles (NPs) have shown great potential overcoming these challenges facilitating targeted drug transport LNs directly or indirectly activating T cells. This review systematically examines structural features key factors influencing targeting efficiency NPs, current strategies for remodeling LNs. Additionally, it discusses future opportunities optimizing NPs enhance immunotherapy, addressing translation safety evaluation.

Language: Английский

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Stabilization of chitosan-based nanomedicines in cancer therapy: a review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143016 - 143016

Published: April 1, 2025

Language: Английский

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The review of nasal drug delivery system: The strategies to enhance the efficiency of intranasal drug delivery by improving drug absorption

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125584 - 125584

Published: April 1, 2025

Language: Английский

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Nanotheranostics Revolutionizing Gene Therapy: Emerging Applications in Gene Delivery Enhancement

Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(2), P. 10 - 10

Published: April 9, 2025

Nanotheranostics—where nanoscale materials serve both diagnostic and therapeutic functions—are rapidly transforming gene therapy by tackling critical delivery challenges. This review explores the design engineering of various nanoparticle systems (lipid-based, polymeric, inorganic, hybrid) to enhance stability, targeting, endosomal escape genetic payloads. We discuss how real-time imaging capabilities integrated into these platforms enable precise localization controlled release genes, improving treatment efficacy while reducing off-target effects. Key strategies overcome barriers (such as proton sponge effect photothermal disruption) achieve nuclear are highlighted, along with recent advances in stimuli-responsive that facilitate spatiotemporal control expression. Clinical trials preclinical studies demonstrate expanding role nanotheranostics managing cancer, inherited disorders, cardiovascular neurological diseases. further address regulatory manufacturing hurdles must be for widespread clinical adoption nanoparticle-based therapies. By synthesizing progress ongoing challenges, this underscores transformative potential effective, targeted, image-guided delivery.

Language: Английский

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Chylomicron-biomimetic nanoparticles promote intestinal lymphatic transport by fast fusion with chylomicrons

Published: April 28, 2025

Intestinal lymphatic transport (ILT) represents a promising pathway for the oral absorption of macromolecular drugs, but formation lipid droplet is rate-limiting step during ILT. In this study, we developed chylomicron (CM)-biomimetic nanoparticle constructed from CM components, characterized by high lipoprotein affinity, to enable efficient delivery anti-fibrotic protein klotho via This approach demonstrated potent therapeutic efficacy in treatment renal fibrosis. The exhibited size stability and retained 78.3% enzyme activity after 12 hours incubation simulated digestive fluid, while facilitating rapid diffusion through mucus layer. Within enterocytes, underwent CM-like transcytosis process showed preference ILT, as evidenced cannulation into main mesenteric duct rats. Notably, biocompatible achieved an absolute bioavailability 2.7%, delivering superior mouse disease model compared 125-fold higher dose intraperitoneally administered captopril, first-line drug. Our innovative design based on affinity enables enhanced drugs

Language: Английский

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Lipid nanoparticles as a strategy to enhance abiraterone acetate oral bioavailability: insights into intestinal uptake and pharmacokinetic profiles

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106947 - 106947

Published: April 1, 2025

Language: Английский

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Development and Evaluation of the Biological Activities of a Plain Mucoadhesive Hydrogel as a Potential Vehicle for Oral Mucosal Drug Delivery

Gels, Journal Year: 2024, Volume and Issue: 10(9), P. 574 - 574

Published: Sept. 3, 2024

This study aimed to develop HGs based on cationic guar gum (CGG), polyethylene glycol (PEG), propylene (PG), and citric acid (CA) using a 2

Language: Английский

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Mechanism of charge self-reversal nano-nutrient delivery system to overcome the mucosal barrier

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 155594 - 155594

Published: Sept. 1, 2024

Language: Английский

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Construction of a charge-reversal polyelectrolyte nanocarrier for targeted intestinal releasing of kidney tea saponin based on sodium alginate/ε-polylysine/alliin

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 287, P. 138424 - 138424

Published: Dec. 9, 2024

Language: Английский

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Lipid Nanoparticles as a Strategy to Enhance Abiraterone Acetate Oral Bioavailability: Insights into Intestinal Uptake and Pharmacokinetic Profiles

Published: Jan. 1, 2024

Language: Английский

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