Novel Supramolecular Hydrogel for Infected Diabetic Foot Ulcer Treatment

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Abstract Multifunctional responsive hydrogels hold significant promise for diabetic foot ulcer (DFU) treatment, though their complex design and manufacturing present challenges. This study introduces a novel supramolecular guanosine‐phenylboronic‐chlorogenic acid (GBC) hydrogel developed using dynamic covalent strategy. The forms through guanosine quadruplex assembly in the presence of potassium ions chlorogenic (CA) linkage via borate bonds. GBC exhibit pH glucose responsiveness, releasing more under acidic high conditions due to bond dissociation G‐quadruplex (G4) disintegration. Experimental results indicate that good self‐healing, shear‐thinning, injectability, swelling properties. Both vitro vivo studies demonstrate hydrogel's biocompatibility, ability eliminate bacteria reactive oxygen species (ROS), facilitate macrophage polarization from M1 phenotype M2 (decreasing CD86 expression increasing CD206 expression), anti‐inflammatory effects (reducing TNF‐α IL‐10 promote angiogenesis (increasing VEGF, CD31, α‐SMA expression). Thus, accelerate DFU healing enhance tissue remodeling collagen deposition. work provides new approach developing expedite healing.

Language: Английский

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Interspecies comparison on the O-methylation metabolism of LJR003, a novel immunomodulator targeting acetyl-CoA acetyltransferase 1

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 116894 - 116894

Published: April 1, 2025

Language: Английский

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Trojan Horse Delivery Strategies of Natural Medicine Monomers: Challenges and Limitations in Improving Brain Targeting

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 280 - 280

Published: Feb. 20, 2025

Central nervous system (CNS) diseases, such as brain tumors, Alzheimer’s disease, and Parkinson’s significantly impact patients’ quality of life impose substantial economic burdens on society. The blood–brain barrier (BBB) limits the effective delivery most therapeutic drugs, especially natural products, despite their potential effects. Trojan Horse strategy, using nanotechnology to disguise drugs “cargo”, enables them bypass BBB, enhancing targeting efficacy. This review explores applications products in treatment CNS discusses challenges posed by analyzes advantages limitations strategy. Despite existing technical challenges, future research is expected enhance application integrating nanotechnology, improving mechanisms, optimizing characteristics.

Language: Английский

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Anhydrous interfacial polymerization induced by isopropanol to construct high permeance polyamide membranes for organic solvent nanofiltration

Journal of Membrane Science, Journal Year: 2024, Volume and Issue: unknown, P. 123516 - 123516

Published: Nov. 1, 2024

Language: Английский

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Chlorogenic Acid: A Promising Strategy for Milk Preservation by Inhibiting Staphylococcus aureus Growth and Biofilm Formation

Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4104 - 4104

Published: Dec. 18, 2024

Chlorogenic acid (CGA), a polyhydroxy phenolic acid, has been extensively studied for its antimicrobial properties. Staphylococcus aureus (S. aureus) threatens food safety by forming biofilms. This study aimed to investigate the mechanism of CGA against S. and biofilm. The anti-bacterial activity was assessed using crystal violet staining, TEM, SEM, CLSM, metabolomics molecular docking elucidate mechanism. results indicated that minimum inhibitory concentration 2.5 mg/mL. disrupts integrity bacterial cell membranes, leading increased hydrophobicity, morphological changes, scattering, reduced spreading. disruption decreases biofilm adhesion count. Metabolomics analyses revealed down-regulates key amino acids. It forms hydrogen bonds with penicillin-binding protein 4 (PBP4), Amidase, glutamate synthetase B, A. By inhibiting metabolism, prevents formation. interacts acids such as aspartic glutamine, through hydroxyl (-OH) carbonyl (-C=O) groups. interaction reduces viability cohesion. novel findings this study, particularly extension shelf life pasteurized milk growth, highlight potential promising anti-biofilm strategy preservative in dairy industry.

Language: Английский

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Chemoproteomic Profiling Reveals Chlorogenic Acid as a Covalent Inhibitor of Arabidopsis Dehydroascorbate Reductase 1

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Chlorogenic acid (CA) is an abundant plant secondary metabolite with promising allelopathic effects on weed growth. However, the molecular targets and mechanism of action CA in plants remain elusive. Here, we report employment a clickable photoaffinity probe identifying protein Arabidopsis seedling proteomes. specifically binds dehydroascorbate reductase 1 (AtDHAR1), enzyme responsible for ascorbate regeneration plants, by covalent alkylating Cys20 within catalytic center, thereby inhibiting its activity. In vivo application reduced pool size redox state ascorbate, leading to H2O2 accumulation seedlings. agreement these results, significantly induced upregulation antioxidant enzymes downregulation proteins involved water transport photosynthesis, as evidenced quantitative proteomics. Taken together, this study revealed DHAR1 functional target underlying CA's activity which opens new opportunities development novel herbicides from naturally existing resources.

Language: Английский

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Anhydrous Interfacial Polymerization Induced by Isopropanol to Construct High Permeance Polyamide Membranes for Organic Solvent Nanofiltration

Published: Jan. 1, 2024

Language: Английский

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Association between ACAT1 rs11545566 Polymorphism and Susceptibility to Non-Alcoholic Fatty Liver Disease

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(12), P. 809 - 816

Published: Jan. 1, 2024

Language: Английский

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