Highly Stretchable, Transparent, and Adhesive Double-Network Hydrogel Dressings Tailored with Fish Gelatin and Glycyrrhizic Acid for Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(36), P. 42304 - 42316

Published: Aug. 30, 2023

It remains challenging to fabricate highly stretchable and adhesive hydrogel dressings for wound healing using simple, safe, green methods. Herein, inspired by the main components of snail mucus, a fully physical double-network (DN) dressing composed fish gelatin (FGel) glycyrrhizic acid (GL) was fabricated, in which FGel provided protein scaffold mimic mucus proteins, while GL mimicked adhesion bioactivity because its abundant carboxyl hydroxyl groups intrinsic immunomodulatory activity. As expected, obtained FGel/GL exhibited outstanding mechanical performances (flexibility, stretchability, ability, removability), high transparency, good antifreezing properties. More importantly, they also possessed excellent biocompatibility, cell migration, angiogenesis ability vitro experiments. Finally, animal experiments vivo indicated that significantly promoted full-thickness healing, including promoting granulation tissue formation, collagen deposition, skin inhibiting inflammatory response. All these findings have great potential applications clinical treatment healing.

Language: Английский

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Electrophoretic deposition of photothermal responsive antibacterial coatings on titanium with controlled release of silver ions

Progress in Organic Coatings, Journal Year: 2024, Volume and Issue: 188, P. 108207 - 108207

Published: Jan. 16, 2024

Language: Английский

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A review on surface modification of nanofibrous textiles for diverse applications: Focus on medical uses

Heliyon, Journal Year: 2025, Volume and Issue: 11(2), P. e41863 - e41863

Published: Jan. 1, 2025

Electrospun nanofibers with a high surface area are attractive materials for biomedical applications. They have potential use in scaffolds, drug delivery, bio face masks, wound dressings, and biosensors. Various modifications been developed to improve their chemical physical properties. These include physical, chemical, biological, nano-treatment approaches. The modification includes annealing, stretching, plasma treatment. Chemical functionalization groups, while biological involves coating proteins, enzymes, or antibodies. Nanotreatment approaches nanomaterials modify the of nanofibers. enhance characteristics nanofibers, making them more effective efficient intended review summarizes latest research on electrospun nanofiber procedures, strategies, utilities various It provides insights into conditions requirements each approach effects properties Moreover, it emphasizes importance functionalizing meet most important specific

Language: Английский

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Low-cost, reliable and flexible piezoresistive pressure sensors coated with single layer graphene and silver nanowires on three-dimensional polyurethane sponge

Sensors and Actuators A Physical, Journal Year: 2024, Volume and Issue: 375, P. 115524 - 115524

Published: June 1, 2024

Language: Английский

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An All‐In‐One Transient Theranostic Platform for Intelligent Management of Hemorrhage

Advanced Science, Journal Year: 2023, Volume and Issue: 10(24)

Published: June 4, 2023

Abstract Developing theranostic devices to detect bleeding and effectively control hemorrhage in the prehospital setting is an unmet medical need. Herein, all‐in‐one platform presented, which constructed by sandwiching silk fibroin (SF) between two silver nanowire (AgNW) based conductive electrodes non‐enzymatically diagnose local stop at wound site. Taking advantage of hemostatic property natural SF, device composed a shape‐memory SF sponge, facilitating blood clotting, with ≈82% reduction time vitro as compared untreated blood. Furthermore, this sandwiched serves capacitive sensor that can differentiate other body fluids (i.e., serum water) via capacitance change. In addition, AgNW electrode endows anti‐infection efficiency against Escherichia coli Staphylococcus aureus . Also, shows excellent biocompatibility gradually biodegrades vivo no major or systemic inflammatory responses. More importantly, presents considerable efficacy comparable commercial hemostat, Dengen, rat liver models. The provides unexplored strategy for intelligent management hemorrhage, potential significantly improve patients' well‐being through integration diagnostic therapeutic capabilities.

Language: Английский

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Electrospun nanofibrous scaffolds of polylactic acid loaded with ginger/MoO3/CuO/graphene oxide: biocompatibility and antibacterial activity

Polymer Bulletin, Journal Year: 2024, Volume and Issue: 81(14), P. 12921 - 12946

Published: May 28, 2024

Language: Английский

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Preparation Method and Application of Porous Poly(lactic acid) Membranes: A Review

Polymers, Journal Year: 2024, Volume and Issue: 16(13), P. 1846 - 1846

Published: June 28, 2024

Porous membrane technology has garnered significant attention in the fields of separation and biology due to its remarkable contributions green chemistry sustainable development. The porous membranes fabricated from polylactic acid (PLA) possess numerous advantages, including a low relative density, high specific surface area, biodegradability, excellent biocompatibility. As result, they exhibit promising prospects for various applications, such as oil–water separation, tissue engineering, drug release. This paper provides an overview recent research advancements fabrication PLA using electrospinning, breath-figure method, phase method. Firstly, principles each method are elucidated perspective pore formation. correlation between relevant parameters structure is discussed summarized, subsequently followed by comparative analysis advantages limitations Subsequently, this article presents diverse applications other fields. current challenges faced these membranes, however, encompass inadequate mechanical strength, limited production efficiency, complexity control. Suggestions enhancement, well future prospects, provided accordingly.

Language: Английский

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Fabrication and Characterization of Polylactic Acid Electrospun Wound Dressing Modified with Polyethylene Glycol, Rosmarinic Acid and Graphite Oxide

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(13), P. 2000 - 2000

Published: July 3, 2023

Polylactic acid (PLA) is a biodegradable polymer made from natural sources, and its electrospinning (e-spinning) nanofiber membrane doped with antibacterial ingredients widely used in the field of medical dressings. In this research, 9 wt% rosmarinic (RosA) 0.04 graphite oxide (GO) synergistic activity were introduced into e-spinning PLA precursor solution, obtained showed good properties wound healing effects. At same time, nonionic amphiphilic polymer, polyethylene glycol (PEG), was also system to improve hydrophilicity for application. The morphological characterization RosA/GO PEG did not affect PLA. tests mechanical performance wettability demonstrated that incorporated have migrated easily surface fiber. e-spun PLA/PEG/RosA/GO promoted initial quickly, which would be promising application dressing.

Language: Английский

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Electrically Conductive Polypyrrole@keratin Nanofiber Membranes with Potential for Tissue Restoration

Fibers and Polymers, Journal Year: 2024, Volume and Issue: 25(3), P. 751 - 763

Published: Jan. 28, 2024

Language: Английский

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PLA/AgNPs fiber aerogels and its investigation into their antibacterial properties

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1317, P. 139189 - 139189

Published: July 2, 2024

Language: Английский

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