Current status and development prospects of aquatic vaccines

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 10, 2022

Diseases are a significant impediment to aquaculture’s sustainable and healthy growth. The aquaculture industry is suffering financial losses as result of the worsening water quality increasing frequency aquatic disease outbreaks caused by expansion aquaculture. Drug control, immunoprophylaxis, ecologically integrated etc. principal control strategies for fish infections. For long time, prevention diseases have mainly relied on use various antibiotics chemical drugs. However, long-term inputs not only increases pathogenic bacteria resistance but also damages environments, resulting in drug residues products, severely impeding development industry. vaccines safest most effective ways prevent animal preserve health sustainability To give references implementation vaccines, this study reviews history, types, inoculation techniques, mechanisms action, prospects, challenges encountered with vaccines.

Language: Английский

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Tilapia Lake Virus Vaccine Development: A Review on the Recent Advances

Vaccines, Journal Year: 2023, Volume and Issue: 11(2), P. 251 - 251

Published: Jan. 23, 2023

Tilapia tilapinevirus (or tilapia lake virus, TiLV) is a recently emerging virus associated with novel disease affecting and decimating populations around the world. Since its initial identification, TiLV has been reported in 17 countries, often causing mortalities as high 90% affected populations. To date, no therapeutics or commercial vaccines exist for control. exposed to can develop protective immunity, suggesting that vaccination achievable. Given important role of fish farming, several vaccine strategies are currently being explored put forward against but, comprehensive overview on efficacy these platforms lacking. We here present approaches relation previously developed discuss their efficacy, administration routes, various factors impact efficacy. The overall recent advances development show different but promising levels protection. field however hampered by lack knowledge biology TiLV, notably function genes. Further research incorporation including prime–boost regimens, codon optimization, reverse vaccinology would be beneficial increase effectiveness targeting further discussed this review.

Language: Английский

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Advances in biomimetic nanomaterial delivery systems: harnessing nature's inspiration for targeted drug delivery

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(29), P. 7001 - 7019

Published: Jan. 1, 2024

The properties of nanomaterials make them promising and advantageous for use in drug delivery systems, but challenges arise from the immune system's recognition exogenous nanoparticles, leading to their clearance reduced targeting efficiency.

Language: Английский

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Addressing Nanovaccine Strategies for Tilapia

Vaccines, Journal Year: 2023, Volume and Issue: 11(8), P. 1356 - 1356

Published: Aug. 11, 2023

Tilapia is the world’s most extensively farmed species after carp. It an attractive for aquaculture as it grows quickly, reaching harvest size within six to seven months of production, and provides important source food revenue many low-income families, especially in low- middle-income countries. The expansion tilapia has resulted intensification farming systems, this been associated with increased disease outbreaks caused by various pathogens, mostly bacterial viral agents. Vaccination routinely used control higher-value finfish species, such Atlantic salmon. At same time, farmers are often unwilling vaccinate their fish injection once have moved grow-out site. Alternative vaccination strategies needed help accept use vaccines. There increasing interest nanoparticle-based vaccines alternative methods delivering fish, oral immersion administration. They can potentially improve vaccine efficacy through controlled release antigens, protecting antigens from premature proteolytic degradation gastric tract, facilitating antigen uptake processing antigen-presenting cells. also allow targeted delivery at mucosal sites. This review a brief overview diseases affecting tilapia. focuses on nanovaccines acceptance farmers.

Language: Английский

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Combining Phage Display Technology with In Silico -Designed Epitope Vaccine to Elicit Robust Antibody Responses against Emerging Pathogen Tilapia Lake Virus

Journal of Virology, Journal Year: 2023, Volume and Issue: 97(4)

Published: March 28, 2023

Antigen epitope identification is a critical step in the vaccine development process and momentous cornerstone for of safe efficient vaccines. In particular, design difficult when function protein encoded by pathogen unknown. The genome Tilapia lake virus (TiLV), an emerging from fish, encodes functions that have not been elucidated, resulting lag uncertainty development. Here, we propose feasible strategy viral disease using TiLV. We determined targets specific antibodies serum TiLV survivor panning Ph.D.-12 phage library, identified mimotope, TYTTRMHITLPI, referred to as Pep3, which provided protection against after prime-boost vaccination; its immune rate was 57.6%. Based on amino acid sequence alignment structure analysis target TiLV, further protective antigenic site (399TYTTRNEDFLPT410) located segment 1 (S1). with keyhole limpet hemocyanin (KLH-S1399-410) corresponding mimotope induced tilapia produce durable effective antibody response immunization, depletion test confirmed S1399-410 necessary neutralize Surprisingly, challenge studies demonstrated elicited robust challenge, survival reached 81.8%. conclusion, this study revealed concept screening antigen epitopes diseases, providing promising approaches evaluation vaccines diseases. IMPORTANCE determination important developing study, attempted explore novel approach discovery new fish. investigated immunogenicity efficacy all sites (mimotopes) primary survivors library. also recognized natural bioinformatics, evaluated effect 2 residues play roles epitope. Both Pep3 (a Pep3) titers tilapia, but more prominent. Antibody showed anti-S1399-410-specific were essential neutralizing Our model combining experimental computational screens identify epitopes, attractive epitope-based

Language: Английский

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Chitosan nanoparticle immersion vaccine offers protection against tilapia lake virus in laboratory and field studies

Fish & Shellfish Immunology, Journal Year: 2022, Volume and Issue: 131, P. 972 - 979

Published: Nov. 6, 2022

Language: Английский

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Development of Immersion and Oral Bivalent Nanovaccines for Streptococcosis and Columnaris Disease Prevention in Fry and Fingerling Asian Seabass (Lates calcarifer) Nursery Farms

Vaccines, Journal Year: 2023, Volume and Issue: 12(1), P. 17 - 17

Published: Dec. 22, 2023

In the present study, chitosan-based bivalent nanovaccines of S. iniae and F. covae were administered by immersion vaccination at 30 40 days after hatching (DAH), third was orally feeding 50 DAH. ELISA revealed that levels total IgM specific to significantly elevated in all vaccinated groups 10, 20, (DAV). A qRT-PCR analysis immune-related genes higher IgT expression compared control group, as 44–100-fold changes (p < 0.001) every tested time point vaccination. All expressed IgM, MHCIIα, TCRα than group 10 and/or 20 DAV 0.05). challenge tests, survival ranged from 62.15 ± 2.11 75.70 3.36%, which differed (44.44 1.92%). Similarly, showed rates 68.89 3.85 77.78 5.09% during (50.00 3.33%)

Language: Английский

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Self-assembled nanoparticle vaccine based on the grass carp ferritin remarkably enhance the protective immune responses against GCRV type II infection

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742349 - 742349

Published: Feb. 1, 2025

Language: Английский

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Multi-epitope microsphere vaccine modified immunological efficacy against LMBV in largemouth bass (Micropterus salmoides)

Virology, Journal Year: 2025, Volume and Issue: 608, P. 110553 - 110553

Published: April 18, 2025

Language: Английский

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Anti-oxidative and anti-aging effects of mannoprotein-rich yeast cell wall enzymatic hydrolysate by modulating gut microbiota and metabolites in Caenorhabditis elegans

Food Research International, Journal Year: 2023, Volume and Issue: 170, P. 112753 - 112753

Published: April 7, 2023

Language: Английский

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