Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 21, 2024
Abstract
Calcium
phosphate
(CaP)
polymorphs
are
non-toxic
and
biocompatible,
making
them
intriguing
for
a
variety
of
applications,
including
hard
tissue
regeneration,
medicine
delivery,
vaccine
development.
Investigating
the
mechanism
calcium
nucleation
development
is
critical
understanding
disorders
caused
by
pathological
mineralization
developing
biomimetic
materials
with
suitable
properties.
The
current
CaP
in
situ/batch
biomineralization
process
follows
crystal-formation
route
pre-nucleation
cluster
aggregation
particles
larger
than
500
microns.
However,
due
to
their
large
size,
synthesis
methods
may
have
limited
efficiency,
scalability,
particle
uniformity.
new
technologies
producing
nano-
microparticles
biomedicine
interesting
various
reasons.
In
this
context,
microfluidic-based
technology
developed,
distinct
microfluidic
parameters
altered,
chip
architecture
allows
fine
manipulation
reaction
parameters.
obtained
conditions
yielded
20-100-micron
crystal.
Furthermore,
approach
enables
straightforward
encapsulation
two
different
model
dyes:
methylene
blue
(MB)
rose
Bengal
(RB).
proposed
microfluidic-aided
technique
provides
viable
future
study
production
delivery
systems.
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Nanozymes
have
shown
significant
potential
in
cancer
catalytic
therapy
by
strategically
catalyzing
tumor-associated
substances
and
metabolites
into
toxic
reactive
oxygen
species
(ROS)
situ,
thereby
inducing
oxidative
stress
promoting
cell
death.
However,
within
the
complex
tumor
microenvironment
(TME),
rational
design
of
nanozymes
factors
like
activity,
reaction
substrates,
TME
itself
significantly
influence
efficiency
ROS
generation.
To
address
these
limitations,
recent
research
has
focused
on
exploring
that
affect
activity
developing
nanozyme-based
cascade
systems,
which
can
trigger
two
or
more
processes
tumors,
producing
therapeutic
achieving
efficient
stable
with
minimal
side
effects.
This
area
remarkable
progress.
Perspective
provides
a
comprehensive
overview
nanozymes,
covering
their
classification
fundamentals.
The
regulation
nanozyme
strategies
are
discussed
detail.
Furthermore,
representative
paradigms
for
successful
construction
systems
treatment
summarized
focus
revealing
underlying
mechanisms.
Finally,
we
current
challenges
future
prospects
development
biomedical
applications.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 375 - 375
Published: March 15, 2025
Recent
progress
in
material
science
has
led
to
the
development
of
new
drug
delivery
systems
that
go
beyond
conventional
approaches
and
offer
greater
accuracy
convenience
application
therapeutic
agents.
This
review
discusses
evolutionary
role
nanocarriers,
hydrogels,
bioresponsive
polymers
enhanced
release,
target
accuracy,
bioavailability.
Oncology,
chronic
disease
management,
vaccine
are
some
applications
explored
this
paper
show
how
these
materials
improve
results,
counteract
multidrug
resistance,
allow
for
sustained
localized
treatments.
The
also
translational
barriers
bringing
advanced
into
clinical
setting,
which
include
issues
biocompatibility,
scalability,
regulatory
approval.
Methods
overcome
challenges
surface
modifications
reduce
immunogenicity,
scalable
production
methods
such
as
microfluidics,
harmonization
systems.
In
addition,
convergence
artificial
intelligence
(AI)
machine
learning
(ML)
is
opening
frontiers
personalized
medicine.
These
technologies
predictive
modeling
real-time
adjustments
optimize
needs
individual
patients.
use
can
be
applied
rare
underserved
diseases;
thus,
strategies
gene
therapy,
orphan
drugs
development,
global
distribution
may
hopes
millions
Cancers,
Journal Year:
2024,
Volume and Issue:
16(17), P. 2975 - 2975
Published: Aug. 27, 2024
Malignant
gliomas
present
great
difficulties
in
treatment,
with
little
change
over
the
past
30
years
median
survival
time
of
15
months.
Current
treatment
options
include
surgery,
radiotherapy
(RT),
and
chemotherapy.
New
therapies
aimed
at
suppressing
formation
new
vasculature
(antiangiogenic
treatments)
or
destroying
formed
tumor
(vascular
disrupting
agents)
show
promise.
This
study
summarizes
existing
knowledge
regarding
processes
by
which
glioblastoma
(GBM)
tumors
acquire
resistance
to
antiangiogenic
treatments.
The
discussion
encompasses
activation
redundant
proangiogenic
pathways,
heightened
cell
invasion
metastasis,
induced
hypoxia,
creation
vascular
mimicry
channels,
regulation
immune
microenvironment.
Subsequently,
we
explore
potential
strategies
overcome
this
resistance,
such
as
combining
other
methods,
personalizing
treatments
for
each
patient,
focusing
on
therapeutic
targets,
incorporating
immunotherapy,
utilizing
drug
delivery
systems
based
nanoparticles.
Additionally,
would
like
discuss
limitations
methods
future
directions
enhance
beneficial
effects
patients
GBM.
Therefore,
review
aims
research
outcome
GBM
provide
a
more
promising
opportunity
thoroughly
exploring
mechanisms
investigating
novel
strategies.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(11)
Published: Nov. 1, 2024
Abstract
Small
molecule
drugs
are
increasingly
emerging
as
innovative
and
effective
treatments
for
various
diseases,
with
mRNA
therapeutics
being
a
notable
representative.
The
success
of
COVID‐19
vaccines
has
underscored
the
transformative
potential
in
RNA
therapeutics.
Within
family,
there
is
another
unique
type
known
circRNA.
This
single‐stranded
closed‐loop
offers
advantages
over
mRNA,
including
enhanced
stability
prolonged
protein
expression,
which
may
significantly
impact
therapeutic
strategies.
Furthermore,
circRNA
plays
pivotal
role
pathogenesis
such
cancers,
autoimmune
disorders,
cardiovascular
making
it
promising
clinical
intervention
target.
Despite
these
benefits,
application
settings
remains
underexplored.
review
provides
comprehensive
overview
current
state
synthetic
therapeutics,
focusing
on
its
synthesis,
optimization,
delivery,
diverse
applications.
It
also
addresses
challenges
impeding
advancement
from
bench
to
bedside.
By
summarizing
aspects,
aims
equip
researchers
insights
into
ongoing
developments
future
directions
Highlighting
both
progress
existing
gaps
research,
this
valuable
perspectives
advancing
field
guiding
investigations.
BIO Integration,
Journal Year:
2025,
Volume and Issue:
6(1)
Published: Jan. 1, 2025
Pulmonary
fibrosis
(PF)
is
a
progressive
interstitial
lung
disease
characterized
by
excessive
extracellular
matrix
deposition
and
tissue
scarring,
leading
to
impaired
function
respiratory
failure.
Although
current
treatments,
such
as
pirfenidone
nintedanib,
slow
progression,
they
fail
completely
halt
or
reverse
fibrosis.
Therefore,
innovative
therapeutic
strategies
are
needed.
Targeted
drug
delivery
systems
(TDDSs)
emerging
promising
solutions.
Biomaterials
play
critical
roles
in
these
enhancing
specificity,
availability,
efficacy,
while
minimizing
systemic
toxicity.
The
most
notable
biomaterials
include
nanotechnology-based
systems,
including
liposomes
polymeric
nanoparticles,
which
facilitate
penetration
release
fibrotic
tissues.
Hydrogels
have
three-dimensional
structures
providing
controlled
sustained
at
inflammation
sites,
therefore
particularly
valuable
PF
treatment.
Furthermore,
biological
carriers
stem
cells
vesicles
biocompatibility
anti-inflammatory
effects
that
improve
outcomes.
Despite
the
potential
of
clinical
translation
hindered
several
challenges,
immune
clearance,
stability
platforms,
optimization
retention
within
diseased
Interdisciplinary
approaches
integrating
precision
medicine
with
advancements
may
provide
solutions
opening
new
avenues
for
This
review
discusses
developments
targeted
PF,
emphasizing
importance
biomaterials,
mechanisms
barriers
involved
pulmonary
delivery,
future
perspectives
overcoming
limitations.
ultimate
goal
patient
outcomes
revolutionizing
approach
treatment
through
advanced
technologies.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 4, 2025
Microalgae
are
emerging
as
a
key
player
in
healthcare,
functional
foods,
and
sustainable
biotech
due
to
their
capacity
produce
bioactive
compounds
like
β-glucans,
omega-3
fatty
acids,
antioxidants
an
eco-friendly
manner.
This
review
comprehensively
discusses
the
role
of
microalgae
healthcare
focusing
particularly
on
β-glucan
therapeutics,
drug
delivery
innovations,
synthetic
biology
applications.
In
microalgae-derived
show
immense
promise
for
treating
diseases,
boosting
immunity,
tackling
oxidative
stress.
Euglena
-derived
paramylon,
type
β-glucan,
has
shown
potential
various
medical
applications,
including
immunomodulation
anticancer
therapy.
Synthetic
bioprocess
engineering
enhancing
microalgae’s
therapeutic
nutritional
value,
with
applications
personalized
medicine.
To
maximize
microalgae,
further
research
development
needed
address
scalability,
regulatory
alignment,
consumer
acceptance,
focus
interdisciplinary
collaboration
practices
align
innovation
environmental
conservation.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 6, 2025
Synthetic
biology
and
nanotechnology
fusion
represent
a
transformative
approach
promoting
fundamental
clinical
biomedical
science
development.
In
SynBioNanoDesign,
biological
systems
are
reimagined
as
dynamic
programmable
materials
to
yield
engineered
nanomaterials
with
emerging
specific
functionalities.
This
review
elucidates
comprehensive
examination
of
synthetic
biology's
pivotal
role
in
advancing
for
targeted
drug
delivery
systems.
It
begins
exploring
the
synergy
between
nanotechnology,
then
highlights
current
landscape
applications.
Subsequently,
discusses
design
novel
informed
by
principles,
focusing
on
expounding
tools
potential
developing
advanced
nanomaterials.
Afterward,
research
advances
innovative
through
were
systematically
summarized,
emphasizing
integration
genetic
circuitry
program
nanomaterial
responses.
Furthermore,
challenges,
weaknesses
opportunities,
prospective
directions,
ethical
societal
implications
SynBioNanoDesign
elucidated.
Finally,
summarizes
impact
that
may
have
drug-delivery
technologies
future.
