Mammalian Cells: Reliability as Model System in the Ecotoxicological Evaluation of Environmental Stressors DOI

Madhuchhanda Adhikari,

Chayan Biswas,

Sukhendu Maity

et al.

Published: Jan. 1, 2023

Disturbance in ecosystem balance is increasing drastically due to human interferences. Different kinds of toxins are continuously being released into the environment from various sources; few naturally produced like cyanotoxins, and rest industries or other activities. Living organisms, including humans, come contact with during their lifetime. To understand level toxicity mechanism action, ecotoxicological evaluation these environmental stressors necessary. Selecting/creating an ideal model system for screening a major concern among scientist. At present, animal models mice, rats, fish, etc., different cell lines used toxicological potential stressors. Mammalian widely predict toxic effects on cellular level, especially perspective. at organism used. This chapter reviews benefits drawbacks teleost, algae, mammalian over lines. will also help vitality systems choosing suitable ones

Language: Английский

Frontiers in quantifying wildlife behavioural responses to chemical pollution DOI Creative Commons
Michael G. Bertram, Jake M. Martin, Erin S. McCallum

et al.

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Journal Year: 2022, Volume and Issue: 97(4), P. 1346 - 1364

Published: March 1, 2022

Animal behaviour is remarkably sensitive to disruption by chemical pollution, with widespread implications for ecological and evolutionary processes in contaminated wildlife populations. However, conventional approaches applied study the impacts of pollutants on seldom address complexity natural environments which contamination occurs. The aim this review guide rapidly developing field behavioural ecotoxicology towards increased environmental realism, complexity, mechanistic understanding. We identify research areas ecology that date have been largely overlooked within but promise yield valuable insights, including within- among-individual variation, social networks collective behaviour, multi-stressor interactions. Further, we feature methodological technological innovations enable collection data pollutant-induced changes at an unprecedented resolution scale laboratory field. In era rapid change, there urgent need advance our understanding real-world pollution behaviour. This therefore provides a roadmap major outstanding questions highlights cross-talk other disciplines order find answers.

Language: Английский

Citations

95

A cross-species comparative approach to assessing multi- and transgenerational effects of endocrine disrupting chemicals DOI Creative Commons
Bernard Robaire, Géraldine Delbès, Jessica Head

et al.

Environmental Research, Journal Year: 2021, Volume and Issue: 204, P. 112063 - 112063

Published: Sept. 22, 2021

A wide range of chemicals have been identified as endocrine disrupting (EDCs) in vertebrate species. Most studies EDCs focused on exposure both male and female adults to these chemicals; however, there is clear evidence that dramatic effects when mature or developing gametes are exposed, consequently associated with multigenerational transgenerational effects. Several publications reviewed such actions subgroups species, e.g., fish rodents. In this review, we take a holistic approach synthesizing knowledge the across including fish, anurans, birds, mammals, discuss potential mechanism(s) mediating multi- We also propose series recommendations aimed at moving field forward structured coherent manner.

Language: Английский

Citations

49

Towards improved fish tests in ecotoxicology - Efficient chronic and multi-generational testing with the killifish Nothobranchius furzeri DOI
Eli S.J. Thoré, Charlotte Philippe, Luc Brendonck

et al.

Chemosphere, Journal Year: 2021, Volume and Issue: 273, P. 129697 - 129697

Published: Jan. 22, 2021

Language: Английский

Citations

42

Effects of the antidepressant fluoxetine on the swimming behaviour of the amphipod Gammarus pulex: Comparison of short-term and long-term toxicity in the laboratory and the semi-field DOI Creative Commons
Lara M. Schuijt,

Oluwafemi D. Olusoiji,

Asmita Dubey

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 872, P. 162173 - 162173

Published: Feb. 11, 2023

Fluoxetine is one of the worlds most prescribed antidepressant, and frequently detected in surface waters. Once present aquatic environment, fluoxetine has been shown to disrupt swimming behaviour fish invertebrates. However, also known be highly variable according experimental conditions, potentially concealing relevant effects. Therefore, aims this study were two-fold: i) investigate feeding Gammarus pulex after exposure antidepressant (0.2, 2, 20, 200 μg/L), ii) assess what degree test duration (short-term long-term) location (laboratory semi-field conditions) affect gammarid's behaviour. We used automated video tracking analysis asses a range behaviours G. pulex, including speed, startle responses light transition, acceleration, curvature thigmotaxis. found larger effects on due conditions than tested concentrations. Gammarids swam faster, more straight showed stronger response during transition when kept under compared laboratory. Effects for different durations opposite laboratory semi-field. In gammarids slower spent time at inner zone arena 2 days 21 while reverse was observed. had only minor impacts but influenced behavioural outcomes exposure. Overall, our results highlight importance standardizing optimizing protocols that achieve reproducible ecotoxicology.

Language: Английский

Citations

15

A latest progress in the study of fish behavior: cross-generational effects of behavior under pollution pressure and new technologies for behavior monitoring DOI

Jian-Xue Feng,

Ping Li, Yuan Liu

et al.

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(8), P. 11529 - 11542

Published: Jan. 12, 2024

Language: Английский

Citations

5

Assessment of the exposure of two pesticides on common carp (Cyprinus carpio Linnaeus, 1758): Are the prolonged biomarker responses adaptive or destructive? DOI Creative Commons
Vesela Yancheva,

Еlenka Georgieva,

Iliana Velcheva

et al.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2022, Volume and Issue: 261, P. 109446 - 109446

Published: Aug. 24, 2022

Chlorpyrifos (CPF) and cypermethrin (CYP) are two insecticides that have a proven negative effect on non-target aquatic organisms when they enter the surface waters. However, literature comparative effects of these pesticides important aquaculture fish species, such as common carp (Cyprinus carpio Linnaeus, 1758) is not yet scientifically detailed, especially over long-term. The idea conducting long-term exposure to find out how observed biomarkers would change compared short-term exposure. In natural environment, toxicants present alone, but in combination. By monitoring impact individual substances, state ecosystems exposed various could be predicted. Thus, this study aimed evaluate toxicity different concentrations CYP (0.0002, 0.0003, 0.0006 μg/L) CPF (0.03, 0.05, 0.10 50-L glass tanks C. carpio, for 30 days under laboratory conditions. A set histological biochemical gills liver were applied with chemical analyses water organs. Furthermore, condition hepatosomatic index calculated assess physiological status treated carps. behavioral responses also monitored, respiration rate was analyzed. results suggest had more prominent structure organs, anti-oxidant enzymes, behavior, CPF. addition, indicate susceptible chronic chemically induced cellular stress gills, overall destructive changes rather than adaptive. Regardless scenario, our provide novel insights into pesticide possible biological impacts economically freshwater fish, lower concentrations, based EU legislation (maximum allowable MAC-EQS).

Language: Английский

Citations

22

Warmer temperatures limit the effects of antidepressant pollution on life-history traits DOI Creative Commons
Lucinda C. Aulsebrook, Bob B. M. Wong, Matthew D. Hall

et al.

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2022, Volume and Issue: 289(1968)

Published: Feb. 9, 2022

Pharmaceutical pollutants pose a threat to aquatic ecosystems worldwide. Yet, few studies have considered the interaction between pharmaceuticals and other chronic stressors contemporaneously, even though environmental challenges confronting animals in wild seldom, if ever, occur isolation. Thermal stress is one such challenge that may modify of pharmaceutical pollutants. Accordingly, we investigated how fluoxetine (Prozac), common psychotherapeutic widespread pollutant, interacts with temperature affect life-history traits water flea, Daphnia magna . We chronically exposed two genotypes ecological relevant concentrations (30 ng l −1 300 ) concentration representing levels used acute toxicity tests (3000 quantified change phenotypic trajectories at temperatures (20°C 25°C). Across multiple traits, found exposure impacted fecundity, body size intrinsic growth rate non-monotonic manner 20°C, often genotypic-specific ways. At 25°C, however, phenotypes individuals converged under widely varying fluoxetine, irrespective genotype. Our study underscores importance considering complexity interactions can when assessing effects chemical on traits.

Language: Английский

Citations

20

Antidepressant pharmaceuticals in aquatic systems, individual-level ecotoxicological effects: growth, survival and behavior DOI
Karolina Słoczyńska,

Justyna Orzeł,

Aleksandra Murzyn

et al.

Aquatic Toxicology, Journal Year: 2023, Volume and Issue: 260, P. 106554 - 106554

Published: May 7, 2023

Language: Английский

Citations

13

Interactive effects of carbendazim and cold shock on haematology and behaviour of juvenile Labeo rohita DOI Creative Commons

Muskan Kosriya,

Pravesh Kumar,

Sujit Kumar Nayak

et al.

Discover Environment, Journal Year: 2025, Volume and Issue: 3(1)

Published: April 19, 2025

Language: Английский

Citations

0

Natural daily patterns in fish behaviour may confound results of ecotoxicological testing DOI
Eli S.J. Thoré, Luc Brendonck, Tom Pinceel

et al.

Environmental Pollution, Journal Year: 2021, Volume and Issue: 276, P. 116738 - 116738

Published: Feb. 15, 2021

Language: Английский

Citations

23