Mammalian Cells: Reliability as Model System in the Ecotoxicological Evaluation of Environmental Stressors DOI

Madhuchhanda Adhikari,

Chayan Biswas,

Sukhendu Maity

et al.

Published: Jan. 1, 2023

Disturbance in ecosystem balance is increasing drastically due to human interferences. Different kinds of toxins are continuously being released into the environment from various sources; few naturally produced like cyanotoxins, and rest industries or other activities. Living organisms, including humans, come contact with during their lifetime. To understand level toxicity mechanism action, ecotoxicological evaluation these environmental stressors necessary. Selecting/creating an ideal model system for screening a major concern among scientist. At present, animal models mice, rats, fish, etc., different cell lines used toxicological potential stressors. Mammalian widely predict toxic effects on cellular level, especially perspective. at organism used. This chapter reviews benefits drawbacks teleost, algae, mammalian over lines. will also help vitality systems choosing suitable ones

Language: Английский

Determination of Median Lethal Concentration (LC50) for Endosulfan, Heptachlor and Dieldrin Pesticides to African Catfish, Clarias gariepinus and Their Impact on Its Behavioral Patterns and Histopathological Responses DOI Creative Commons
Md. Ariful Islam, S.M.N. Amin, Christopher L. Brown

et al.

Toxics, Journal Year: 2021, Volume and Issue: 9(12), P. 340 - 340

Published: Dec. 8, 2021

Pesticides such as endosulfan, heptachlor and dieldrin persist in aquatic environments a result of their resistance to biodegradation. However, there is no adequate information about the toxicity organism, African catfish (Clarias gariepinus)—a high valued widely distributed commercially interesting species. The current experiment was performed with aim determine median lethal concentration (LC50) gariepinus); behavioral abnormalities histopathological alterations several vital organs. A total 324 juvenile fish were exposed for 96 h six concentrations endosulfan at 0, 0.001, 0.002, 0.004, 0.008 0.016 ppm, 0.02, 0.04, 0.08, 0.16 0.32 ppm dose-response tests. study demonstrated that species highly susceptible those contaminants showing number changes gill, liver muscle. 96-h LC50 value found 0.004 (0.001−0.01) mg/L, 0.006 mg/L 0.056 (0.006−0.144) respectively. Abnormal behaviors erratic jerky swimming, frequent surfacing movement gulping air, secretion mucus on body gills observed response increasing exposure concentrations. Histopathological liver, gill muscle tissues vacuolization hepatocytes, congestion red blood cells (RBCs) hepatic portal vein; deformed secondary lamellae disintegrated myotomes epidermis, These findings are important monitor responsibly manage pesticide use around C. gariepinus aquacultural areas.

Language: Английский

Citations

21

Long-term exposure to a pharmaceutical pollutant affects geotaxic behaviour in the adult but not juvenile life stage of killifish DOI
Eli S.J. Thoré, Birgit Vanden Berghen, Luc Brendonck

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 876, P. 162746 - 162746

Published: March 11, 2023

Language: Английский

Citations

8

Pesticide sensitivity of Nothobranchius neumanni, a temporary pond predator with a non-generic life-history DOI

Yusuph A. Kafula,

Charlotte Philippe, Tom Pinceel

et al.

Chemosphere, Journal Year: 2021, Volume and Issue: 291, P. 132823 - 132823

Published: Nov. 9, 2021

Language: Английский

Citations

16

Impact of Fluoxetine on Herbivorous Zooplankton and Planktivorous Fish DOI Creative Commons
Małgorzata Grzesiuk,

Eva Gryglewicz,

Piotr Bentkowski

et al.

Environmental Toxicology and Chemistry, Journal Year: 2022, Volume and Issue: 42(2), P. 385 - 392

Published: Nov. 15, 2022

Abstract The contamination of freshwater environments by pharmaceuticals is a growing problem. Modern healthcare uses nearly 3000 substances, many which are designed to work at low dosages and act on physiological systems that have been evolutionarily conserved across taxa. Because drugs affect the organisms from different trophic levels, pharmaceutical pollution likely disturb species interactions. However, such effects still only poorly understood. We investigated impacts environmentally relevant concentrations common drug fluoxetine (Prozac), an increasingly contaminant European waters, predation behavior crucian carp ( Carassius carassius ), planktivorous fish, somatic growth its prey, water flea Daphnia magna widespread planktonic crustacean. exposed these two levels (360 ng L −1 ): fish for 4 weeks fleas generations. tested daphnids hunting (reaction distance attacked feeding rate) under contamination. found grew larger than nonexposed cohort. C. was altered when they were drug; reaction shorter, rate slower. These occurred regardless size treatment regime subjected to. Our results suggest with can disrupt top‐down ecological control herbivores reducing efficiency and, as consequence, may lead increases in cladoceran population numbers. Environ Toxicol Chem 2023;42:385–392. © 2022 Authors. Environmental Toxicology Chemistry published Wiley Periodicals LLC behalf SETAC.

Language: Английский

Citations

12

Effects of long-term fluoxetine exposure on morphology, but not behaviour or metabolic rate, in male guppies (Poecilia reticulata) DOI Creative Commons
Kate N. Fergusson,

James L. Tanner,

Jack A. Brand

et al.

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 107082 - 107082

Published: Sept. 1, 2024

Language: Английский

Citations

2

Context is Key: Social Environment Mediates the Impacts of a Psychoactive Pollutant on Shoaling Behavior in Fish DOI
Rachel T. Mason, Jake M. Martin, Hung Tan

et al.

Environmental Science & Technology, Journal Year: 2021, Volume and Issue: unknown

Published: Sept. 20, 2021

Behavior-modifying drugs, such as antidepressants, are increasingly being detected in waterways and aquatic wildlife around the globe. Typically, behavioral effects of these contaminants assessed using animals tested social isolation. However, for group-living species, seen isolation may not reflect those occurring realistic settings. Furthermore, interactions between chemical pollution other stressors, predation risk, seldom considered. This is true even though wild rarely, if ever, confronted by a single stressor. Here, 2 year multigenerational experiment, we antidepressant fluoxetine (measured concentrations [±SD]: 42.27 ± 36.14 359.06 262.65 ng/L) on shoaling behavior guppies (Poecilia reticulata) across different contexts under varying levels perceived risk. Shoaling propensity shoal choice (choice groups with densities) were Y-maze presence predatory or nonpredatory heterospecific, individually male-female pairs. When individually, no effect was behavior. paired trials, high-fluoxetine-exposed fish exhibited significantly greater propensity. Hence, mediated context, highlighting importance this fundamental but rarely considered factor when evaluating impacts environmental pollution.

Language: Английский

Citations

14

Neurochemical exposure disrupts sex-specific trade-offs between body length and behaviour in a freshwater crustacean DOI
Eli S.J. Thoré, Luc Brendonck, Tom Pinceel

et al.

Aquatic Toxicology, Journal Year: 2021, Volume and Issue: 237, P. 105877 - 105877

Published: May 28, 2021

Language: Английский

Citations

12

Combined effects of global warming and chlorpyrifos exposure on the annual fish Nothobranchius furzeri DOI Creative Commons
Charlotte Philippe, Eli S.J. Thoré, Sebastiaan Verbesselt

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 248, P. 114290 - 114290

Published: Nov. 17, 2022

Global warming and environmental pollution threaten aquatic ecosystems. While interactive effects between both stressors can have more than additive consequences, these remain poorly studied for most taxa. Especially chronic exposure trials with vertebrates are scarce due to the high time- monetary costs of such studies. We use recently-established fish model Nothobranchius furzeri assess separate combined pesticide chlorpyrifos (at 2 µg/L 4 µg/L) a °C temperature increase. performed full life-cycle assessment evaluate fitness-related endpoints including survival, total body length, maturation time, fecundity, critical thermal maximum (CTmax) locomotor activity. Exposure slowed down male maturation, reduced fecundity impaired growth fish. increase did not affect any measured on its own, combination CPF an severely almost no offspring production. Together, findings suggest that climate change may exacerbate impact pollution, multiple should be considered predict how populations will affected by ongoing global change.

Language: Английский

Citations

8

Effects of short-term exposure to a pesticide mixture on free-swimming behavior in goldfish, Carassius auratus DOI Creative Commons

Esmirna Cantu,

Michelle Rivera,

Brittney Lacy

et al.

Journal of Hazardous Materials Advances, Journal Year: 2023, Volume and Issue: 11, P. 100350 - 100350

Published: Aug. 1, 2023

The prevalence of pesticides in the aquatic environment continues to increase due anthropogenic activities and poses a threat organisms. Notably, intensive use can cause detrimental effects (i.e., chemical stressors) on animal behavior. aim this study was determine short-term exposure (5-day) an environmentally relevant pesticide mixture (low- high-dose: metolachlor 2.4 12 μg/L; linuron 2.0 10 isoproturon 1.2 6.0 tebucanazole alconifen 0.8 4.0 atrazine 0.4 pendimethalin; azinphos-methyl μg/L) fish swimming behaviors. Results indicated that low dose decreased distance swam goldfish. Spatial behavior also altered during exposure, with increased time spent lowest horizontal region aquariums both low- high-dose groups. In vertical spatial analysis, all groups showed lowered amounts middle aquariums, especially Collectively, these data indicate significantly alters free-swimming teleost species.

Language: Английский

Citations

4

Fish predation affects invertebrate community structure of tropical temporary ponds, with downstream effects on phytoplankton that are obscured by pesticide pollution DOI

Yusuph A. Kafula,

Gordian Rocky Mataba, Grite Nelson Mwaijengo

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 346, P. 123592 - 123592

Published: Feb. 21, 2024

Language: Английский

Citations

1