Frontiers in Marine Science,
Journal Year:
2024,
Volume and Issue:
11
Published: Sept. 19, 2024
Silver
nanoparticles
(AgNPs)
are
ubiquitous
in
the
aquatic
environment
and
have
attracted
extensive
attention
to
their
toxic
effects
on
species.
However,
responses
of
nervous
system
AgNPs
little
known,
especially
co-existing
with
natural
organic
matter
(NOM),
which
is
critical
for
ability
act
Here,
this
study
investigated
neurotoxicology
environmentally
relevant
or
without
bovine
serum
albumin
(BSA;
a
classical
NOM)
zebrafish
(
Danio
rerio
)
using
visualized
transgenic
zebrafish.
Exposure
reduced
locomotor
behavior
by
28%–45%,
including
swimming
distance
velocity,
exhibiting
obvious
behavioral
inhibition.
The
treated
showed
developmental
retardation
early
development
heart,
central
nervous,
motor
nerve,
as
well
related
neurodevelopment
genes,
may
be
responsible
lowered
behavior.
In
addition,
can
specifically
interfere
cholinergic
affect
neuronal
signaling,
ultimately
leading
abnormalities.
BSA
alleviated
neurotoxicity
zebrafish,
partially
attributed
increased
size
electronegativity
caused
BSA,
thus
reducing
direct
interaction
cells.
between
released
Ag
+
from
also
alleviation
dysfunction
These
findings
provide
valuable
insights
into
toxicity
risks
environments.
