Increased circulating levels of SP-D and IL-10 are associated with the development of disease severity and pulmonary fibrosis in patients with COVID-19

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 14, 2025

Patients with severe COVID-19 can rapidly develop acute respiratory distress syndrome (ARDS), which further increases the risk of developing pulmonary fibrosis. The exact role macrophage polarization and different cytokine production in pathophysiology associated induced ARDS or fibrosis is unknown. It necessary to identify potential biomarkers that predict progress other adverse consequences. We analyze plasma samples obtained from healthy individuals patients who were stratified according disease severity fibrotic-like changes on chest computed tomography (CT) scans. Surfactant Protein D (SP-D), Matrix Metalloproteinase 8 (MMP8), Krebs von den lungen-6 (KL-6), Angiotensin-Converting Enzyme 2 (ACE2), polarization-related determined by ELISA. Data collected evaluated using regression models receiver operating characteristic (ROC) curves. levels SP-D, MMP8 higher than those non-ARDS patients. had SP-D compared without fibrotic changes. Among indicative polarization, patients, a significant increase IL-10, Inducible nitric oxide synthase (iNOS), Arginase-1 (Arg-1) observed while Tumor necrosis factor-α (TNF-α) was decreased. level IL-10 also elevated CT, positively correlated ACE2 Arg-1. ROC curve results uncovered showed efficacy predicting inflammatory markers. And similar predictive value traditional indicators such as CRP PCT. exhibited certain abilities for development COVID-19. determination these cytokines upon admission crucial evaluating prognosis

Language: Английский

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CLINICAL PRESENTATION AND BACTERIOLOGICAL PROFILE OF ICU ADMITTED PATIENTS WITH VENTILATOR ASSOCIATED PNEUMONIA IN KHYBER TEACHING HOSPITAL PESHAWAR

Journal of Khyber College of Dentistry, Journal Year: 2025, Volume and Issue: 15(01), P. 38 - 43

Published: March 18, 2025

Objectives: To determine bacteriological profile of ICU admitted patients with ventilator associated pneumonia.Materials and Methods: A descriptive cross-sectional study was conducted from July 2018 to April 2020 at department Medical ICU. total 172 were observed for clinical presentation in pneumonia. Data presented form frequency percentages.The p-value less than 0.05 considered as statistically significant.Results: Out patients, 24 (13.71%) 18 (10.2%) having Diabetes Mellitus (DM) Hypertension (HTN), respectively. Patients who received mechanical ventilation 0-5 days had a relatively low recovery rate 8.8%, the majority (91%) unfortunately expiring. In 6–10-day category, there slightly higher 14.8%, but still, (85%) did not survive. >16 ventilation, show (35.2%). The highest number bacteria isolated day’s while lowest growth 6-10 ventilated patients. antibiotics susceptibility, are variations antibiotic eff ectiveness across different bacterial strains antibiotics. Fosfomycin Tigecycline ect against all except Acinobacter baumannii Colistin effective Pseudomonas.Conclusion: on lower chances early days, those longer showed better outcomes. common comorbidities. Bacterial ventilation. Antibiotics like whereas also ective all, Pseudomonas.

Language: Английский

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Pulmonary fibrosis complicated by lung cancer: bibliometric analysis from 2004 to 2024 - research status, trends and future directions

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 3, 2025

Objective Although research on the association between pulmonary fibrosis and lung cancer is of great significance, to date, no bibliometric analysis has been conducted comorbidity these two diseases. This study aims explore current status cutting - edge trends in this field through analysis, establish new directions for future research. Methods Using Web Science Core Collection database, statistical calculations, graphic, data visualization tools such as CiteSpace, VOSviewer, Biblimatrix biblioshiny were adopted. Results A total 2,234 original Articles Reviews complicated by published 2004 2024 identified. slow growth trend publications related was observed. The United States, Japan, China countries with greatest contributions. Professor Michael Kreuter from Marienhaus Clinic, Mainz, Germany, University Michigan most articles. Through cluster co cited literature, five main clusters Keyword predicted that “nintedanib”, “pirfenidone”, “immunotherapy”, etc. might become hot topics cancer. Conclusion shows literature a continuous upward trend. hotspots identified provide reference depth field, aiming promote development

Language: Английский

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An Android-Based Predictive Model for Safety Measures of COVID-19 Diseases

Lecture notes in networks and systems, Journal Year: 2025, Volume and Issue: unknown, P. 95 - 106

Published: Jan. 1, 2025

Language: Английский

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A retrospective study of insurance coverage status and economic cost of rare diseases in Hainan Province

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 17, 2025

Rare diseases present a significant economic burden on patients, families, and healthcare systems worldwide. As the prevalence of these rises in China, data regarding their impact, specifically Hainan Province, is scarce. Thus, this study aims to evaluate insurance coverage, costs, factors contributing rare Hainan. We employed bottom-up approach analyse from 2019 2023, utilising Provincial Health Commission Databases. assessed coverage as well expenditures related hospitalisation, diagnostics, medications, surgery, out-of-pocket costs. Of 4,975 patients diagnosed with 99 distinct diseases, 83.01% were insured. From number increased 760 1,328, while costs surged 34.26 million CNY (US$ 4.89 million) 64.74 8.86 million). Thalassemia major, one most prevalent conditions, generated highest Hospitalisation expenses accounted for 49.16% total averaging 17.52%. The findings reveal associated Hainan, highlighting necessity targeted policy interventions. Furthermore, additional research needed refine estimates burden.

Language: Английский

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Impact of COVID-19 Infection on Patients with Preexisting Interstitial Lung Disease: A Spanish Multicentre Study

Archivos de Bronconeumología, Journal Year: 2023, Volume and Issue: 59(4), P. 273 - 276

Published: Jan. 6, 2023

Language: Английский

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Clinical standards for diagnosis, treatment and prevention of post-COVID-19 lung disease

The International Journal of Tuberculosis and Lung Disease, Journal Year: 2023, Volume and Issue: 27(10), P. 729 - 741

Published: Sept. 26, 2023

BACKGROUND: The aim of these clinical standards is to provide guidance on 'best practice' care for the diagnosis, treatment and prevention post-COVID-19 lung disease.METHODS: A panel international experts representing scientific societies, associations groups active in disease was identified; 45 completed a Delphi process. 5-point Likert scale indicated level agreement with draft standards. final version approved by consensus (with 100% agreement).RESULTS: Four were agreed patients previous history COVID-19: Standard 1, Patients sequelae not explained an alternative diagnosis should be evaluated possible disease; 2, function impairment, reduced exercise tolerance, quality life (QoL) or other relevant signs ongoing symptoms ≥4 weeks after onset first pulmonary rehabilitation (PR); 3, PR programme based feasibility, effectiveness cost-effectiveness criteria, organised according local health services tailored individual patient's needs; 4, Each patient undergoing completing determine its have access counselling/health education session.CONCLUSION: This consensus-based set disease. Our improve QoL guiding clinicians, managers public officers planning implementing manage

Language: Английский

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Beyond the Pandemic: The Interplay and Biological Effects of COVID-19 on Cancer Patients -A Mini Review

Al-Salam Journal for Medical Science, Journal Year: 2023, Volume and Issue: 3(1), P. 22 - 27

Published: Dec. 26, 2023

This article delves into the relationship between COVID-19 and cancer. The challenges effects of pandemic on cancer patients are highlighted, along with an explanation most crucial strategies that must be adhered to avoid this virus. Explaining importance healthcare systems in providing services assisting them improve their health condition. concentrates recent studies clinical observations as it allows for accurate comprehensive understanding patients. main issues will focused impact viral infections cancerous tumours while clarifying long-term consequences patients’ lives. goal is inform workers, physicians, researchers about seriousness

Language: Английский

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Impact of obstructive sleep apnea on clinical outcomes of hospitalization due to influenza in children: A propensity score‐matched analysis of the US Nationwide Inpatient Sample 2005–2018

Pediatric Pulmonology, Journal Year: 2024, Volume and Issue: 59(6), P. 1652 - 1660

Published: March 20, 2024

Abstract Background Previous studies have explored the association between obstructive sleep apnea (OSA) and clinical outcomes of influenza in adults, whereas limited research examined this relationship pediatric populations. This study aimed to evaluate impact OSA on hospitalizations. Methods was a population‐based, retrospective study. Data children aged 1–19 years hospitalized for infection were extracted from United States (US) Nationwide Inpatient Sample Database 2005–2018. Univariable multivariable regression analyses determined associations OSA, length stay (LOS), total hospital costs, pneumonia, life‐threatening events. Results After propensity‐score matching, 2100 analyzed. The logistic analysis revealed that with had significantly increased LOS ( β = 2.29 days; 95% confidence interval, CI: 1.01–3.57, p < .001) costs 26.06 thousand dollars; 6.62–45.51, .009), higher odds pneumonia (aged 6–10 years: ratio [OR] 1.52; 1.01–2.27, .043; ≥ 11 OR 1.83; 1.33–2.53, .001). Conclusions During admissions, longer LOS, an risk compared those without OSA. These findings underscore importance recognizing managing influenza‐related infections among children.

Language: Английский

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SARS‐CoV‐2, periodontal pathogens, and host factors: The trinity of oral post‐acute sequelae of COVID‐19

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(3)

Published: May 1, 2024

Abstract COVID‐19 as a pan‐epidemic is waning but there it imperative to understand virus interaction with oral tissues and inflammatory diseases. We review periodontal disease (PD), common disease, driver of post‐acute‐sequelae conditions (PASC). Oral PASC identifies PD, loss teeth, dysgeusia, xerostomia, sialolitis‐sialolith, mucositis. contend that PD‐associated microbial dysbiosis involving higher burden periodontopathic bacteria provide an optimal microenvironment for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. These pathogens interact epithelial cells activate molecular or biochemical pathways promote viral adherence, entry, persistence in the cavity. A repertoire diverse molecules this relationship including lipids, carbohydrates enzymes. The S protein SARS‐CoV‐2 binds ACE2 receptor activated by protease activity host furin TRMPSS2 cleave subunits entry. However, PD additional enzymatic assistance mimicking augment adherence inducing entry receptors ACE2/TRMPSS, which are poorly expressed on cells. discuss mechanisms periodontopathogens factors facilitate infection immune resistance resulting incomplete clearance risk ‘long‐haul’ health issues characterising PASC. Finally, we suggest potential diagnostic markers treatment avenues mitigate

Language: Английский

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