Pentacyclic triterpene oleanolic acid protects against cardiac aging through regulation of mitophagy and mitochondrial integrity DOI Creative Commons
Yan Gong,

Yuanfei Luo,

Suqin Liu

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2022, Volume and Issue: 1868(7), P. 166402 - 166402

Published: March 26, 2022

Language: Английский

Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases DOI
Jun Ren, Yaguang Bi, James R. Sowers

et al.

Nature Reviews Cardiology, Journal Year: 2021, Volume and Issue: 18(7), P. 499 - 521

Published: Feb. 22, 2021

Language: Английский

Citations

491

Ferritinophagy and ferroptosis in the management of metabolic diseases DOI
Amir Ajoolabady,

Hamid Aslkhodapasandhokmabad,

Peter Libby

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2021, Volume and Issue: 32(7), P. 444 - 462

Published: May 15, 2021

Language: Английский

Citations

244

Effects and Mechanisms of Resveratrol on Aging and Age‐Related Diseases DOI Creative Commons
Dan-Dan Zhou, Min Luo, Siyu Huang

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

The aging of population has become an issue great concern because its rapid increase. Aging is important risk factor many chronic diseases. Resveratrol could be found in foods, such as grapes, red wine, peanuts, and blueberries. Many studies reported that resveratrol possessed various bioactivities, antioxidant, anti‐inflammatory, cardiovascular protection, anticancer, antidiabetes mellitus, antiobesity, neuroprotection, antiaging effects. mechanisms were mainly ameliorating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, regulating apoptosis. effective safe compound for the prevention treatment age‐related In this review, we summarize effects on aging, life extension, several diseases, with special attention paid to action.

Language: Английский

Citations

226

Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics DOI Creative Commons
Amir Ajoolabady,

Shuyi Wang,

Guido Kroemer

et al.

Pharmacology & Therapeutics, Journal Year: 2021, Volume and Issue: 225, P. 107848 - 107848

Published: April 4, 2021

Language: Английский

Citations

223

Mitochondrial quality control mechanisms as therapeutic targets in doxorubicin-induced cardiotoxicity DOI
Lin Wu, Litao Wang, Yuxin Du

et al.

Trends in Pharmacological Sciences, Journal Year: 2022, Volume and Issue: 44(1), P. 34 - 49

Published: Nov. 14, 2022

Language: Английский

Citations

142

Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment DOI Creative Commons
Amir Ajoolabady, Mario Chiong, Sergio Lavandero

et al.

Trends in Molecular Medicine, Journal Year: 2022, Volume and Issue: 28(10), P. 836 - 849

Published: July 22, 2022

Language: Английский

Citations

126

FUNDC1 insufficiency sensitizes high fat diet intake-induced cardiac remodeling and contractile anomaly through ACSL4-mediated ferroptosis DOI

Zhaohui Pei,

Yandong Liu, Suqin Liu

et al.

Metabolism, Journal Year: 2021, Volume and Issue: 122, P. 154840 - 154840

Published: July 29, 2021

Language: Английский

Citations

117

Recent advances and trends in nanoparticles based photothermal and photodynamic therapy DOI
Jamileh Kadkhoda, Ali Tarighatnia, Jaleh Barar

et al.

Photodiagnosis and Photodynamic Therapy, Journal Year: 2021, Volume and Issue: 37, P. 102697 - 102697

Published: Dec. 20, 2021

Language: Английский

Citations

112

FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner DOI Creative Commons
Yaguang Bi,

Shuolin Liu,

Xing Qin

et al.

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 55, P. 45 - 60

Published: Feb. 23, 2023

Liver fibrosis is a life-threatening pathological anomaly which usually evolves into advanced liver cirrhosis and hepatocellular carcinoma although limited therapeutic option readily available. FUN14 domain containing 1 (FUNDC1) mitophagy receptor with little information in fibrosis. This study was designed to examine the role for FUNDC1 carbon tetrachloride (CCl4)-induced injury. GEO database analysis subsequent validation of biological processes including western blot, immunofluorescence, co-immunoprecipitation were applied clarify regulatory on ferroptosis. Our data revealed elevated levels tissues patients fibrotic injury CCl4-challenged mice. deletion protected against CCl4-induced hepatic anomalies Moreover, ameliorated ferroptosis vivo vitro. Mechanically, interacted glutathione peroxidase (GPx4), selenoenzyme neutralize lipid hydroperoxides ferroptosis, via its 96–133 amino acid facilitate GPx4 recruitment mitochondria from cytoplasm. entered through mitochondrial protein import system-the translocase outer membrane/translocase inner membrane (TOM/TIM) complex, prior degradation mainly along ROS-induced damaged mitochondria, resulting hepatocyte Taken together, our favored that promoted binding translocation TOM/TIM where degraded by trigger Targeting may be promising approach

Language: Английский

Citations

81

ER stress in obesity pathogenesis and management DOI
Amir Ajoolabady, Simin Liu, Daniel J. Klionsky

et al.

Trends in Pharmacological Sciences, Journal Year: 2021, Volume and Issue: 43(2), P. 97 - 109

Published: Dec. 8, 2021

Language: Английский

Citations

85