
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2022, Volume and Issue: 1868(7), P. 166402 - 166402
Published: March 26, 2022
Language: Английский
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2022, Volume and Issue: 1868(7), P. 166402 - 166402
Published: March 26, 2022
Language: Английский
Nature Reviews Cardiology, Journal Year: 2021, Volume and Issue: 18(7), P. 499 - 521
Published: Feb. 22, 2021
Language: Английский
Citations
491Trends in Endocrinology and Metabolism, Journal Year: 2021, Volume and Issue: 32(7), P. 444 - 462
Published: May 15, 2021
Language: Английский
Citations
244Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)
Published: Jan. 1, 2021
The aging of population has become an issue great concern because its rapid increase. Aging is important risk factor many chronic diseases. Resveratrol could be found in foods, such as grapes, red wine, peanuts, and blueberries. Many studies reported that resveratrol possessed various bioactivities, antioxidant, anti‐inflammatory, cardiovascular protection, anticancer, antidiabetes mellitus, antiobesity, neuroprotection, antiaging effects. mechanisms were mainly ameliorating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, regulating apoptosis. effective safe compound for the prevention treatment age‐related In this review, we summarize effects on aging, life extension, several diseases, with special attention paid to action.
Language: Английский
Citations
226Pharmacology & Therapeutics, Journal Year: 2021, Volume and Issue: 225, P. 107848 - 107848
Published: April 4, 2021
Language: Английский
Citations
223Trends in Pharmacological Sciences, Journal Year: 2022, Volume and Issue: 44(1), P. 34 - 49
Published: Nov. 14, 2022
Language: Английский
Citations
142Trends in Molecular Medicine, Journal Year: 2022, Volume and Issue: 28(10), P. 836 - 849
Published: July 22, 2022
Language: Английский
Citations
126Metabolism, Journal Year: 2021, Volume and Issue: 122, P. 154840 - 154840
Published: July 29, 2021
Language: Английский
Citations
117Photodiagnosis and Photodynamic Therapy, Journal Year: 2021, Volume and Issue: 37, P. 102697 - 102697
Published: Dec. 20, 2021
Language: Английский
Citations
112Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 55, P. 45 - 60
Published: Feb. 23, 2023
Liver fibrosis is a life-threatening pathological anomaly which usually evolves into advanced liver cirrhosis and hepatocellular carcinoma although limited therapeutic option readily available. FUN14 domain containing 1 (FUNDC1) mitophagy receptor with little information in fibrosis. This study was designed to examine the role for FUNDC1 carbon tetrachloride (CCl4)-induced injury. GEO database analysis subsequent validation of biological processes including western blot, immunofluorescence, co-immunoprecipitation were applied clarify regulatory on ferroptosis. Our data revealed elevated levels tissues patients fibrotic injury CCl4-challenged mice. deletion protected against CCl4-induced hepatic anomalies Moreover, ameliorated ferroptosis vivo vitro. Mechanically, interacted glutathione peroxidase (GPx4), selenoenzyme neutralize lipid hydroperoxides ferroptosis, via its 96–133 amino acid facilitate GPx4 recruitment mitochondria from cytoplasm. entered through mitochondrial protein import system-the translocase outer membrane/translocase inner membrane (TOM/TIM) complex, prior degradation mainly along ROS-induced damaged mitochondria, resulting hepatocyte Taken together, our favored that promoted binding translocation TOM/TIM where degraded by trigger Targeting may be promising approach
Language: Английский
Citations
81Trends in Pharmacological Sciences, Journal Year: 2021, Volume and Issue: 43(2), P. 97 - 109
Published: Dec. 8, 2021
Language: Английский
Citations
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