Oxidative Medicine and Cellular Longevity,
Journal Year:
2021,
Volume and Issue:
2021(1)
Published: Jan. 1, 2021
The
aging
of
population
has
become
an
issue
great
concern
because
its
rapid
increase.
Aging
is
important
risk
factor
many
chronic
diseases.
Resveratrol
could
be
found
in
foods,
such
as
grapes,
red
wine,
peanuts,
and
blueberries.
Many
studies
reported
that
resveratrol
possessed
various
bioactivities,
antioxidant,
anti‐inflammatory,
cardiovascular
protection,
anticancer,
antidiabetes
mellitus,
antiobesity,
neuroprotection,
antiaging
effects.
mechanisms
were
mainly
ameliorating
oxidative
stress,
relieving
inflammatory
reaction,
improving
mitochondrial
function,
regulating
apoptosis.
effective
safe
compound
for
the
prevention
treatment
age‐related
In
this
review,
we
summarize
effects
on
aging,
life
extension,
several
diseases,
with
special
attention
paid
to
action.
Journal of Advanced Research,
Journal Year:
2023,
Volume and Issue:
55, P. 45 - 60
Published: Feb. 23, 2023
Liver
fibrosis
is
a
life-threatening
pathological
anomaly
which
usually
evolves
into
advanced
liver
cirrhosis
and
hepatocellular
carcinoma
although
limited
therapeutic
option
readily
available.
FUN14
domain
containing
1
(FUNDC1)
mitophagy
receptor
with
little
information
in
fibrosis.
This
study
was
designed
to
examine
the
role
for
FUNDC1
carbon
tetrachloride
(CCl4)-induced
injury.
GEO
database
analysis
subsequent
validation
of
biological
processes
including
western
blot,
immunofluorescence,
co-immunoprecipitation
were
applied
clarify
regulatory
on
ferroptosis.
Our
data
revealed
elevated
levels
tissues
patients
fibrotic
injury
CCl4-challenged
mice.
deletion
protected
against
CCl4-induced
hepatic
anomalies
Moreover,
ameliorated
ferroptosis
vivo
vitro.
Mechanically,
interacted
glutathione
peroxidase
(GPx4),
selenoenzyme
neutralize
lipid
hydroperoxides
ferroptosis,
via
its
96–133
amino
acid
facilitate
GPx4
recruitment
mitochondria
from
cytoplasm.
entered
through
mitochondrial
protein
import
system-the
translocase
outer
membrane/translocase
inner
membrane
(TOM/TIM)
complex,
prior
degradation
mainly
along
ROS-induced
damaged
mitochondria,
resulting
hepatocyte
Taken
together,
our
favored
that
promoted
binding
translocation
TOM/TIM
where
degraded
by
trigger
Targeting
may
be
promising
approach
