Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 167668 - 167668
Published: Jan. 1, 2025
Language: Английский
Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)
Published: May 29, 2024
Abstract Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role regulating energy metabolism. However, their significance extends beyond this, as they are also indispensable vital life processes such cell proliferation, differentiation, immune responses, and redox balance. In response to various physiological signals or external stimuli, sophisticated mitochondrial quality control (MQC) mechanism has evolved, encompassing key like biogenesis, dynamics, mitophagy, which have garnered increasing attention from researchers unveil specific molecular mechanisms. this review, we present comprehensive summary of primary mechanisms functions regulators involved major components MQC. Furthermore, critical regulated by MQC its diverse roles progression systemic diseases been described detail. We discuss agonists antagonists targeting MQC, aiming explore potential therapeutic research prospects enhancing stabilize function.
Language: Английский
Citations
29
Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155472 - 155472
Published: Feb. 24, 2024
Language: Английский
Citations
20
Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)
Published: March 21, 2024
Abstract Cardiovascular diseases (CVDs) are the main that endanger human health, and their risk factors contribute to high morbidity a rate of hospitalization. Cell death is most important pathophysiology in CVDs. As one cell mechanisms, ferroptosis new form regulated (RCD) broadly participates CVDs (such as myocardial infarction, heart transplantation, atherosclerosis, failure, ischaemia/reperfusion (I/R) injury, atrial fibrillation, cardiomyopathy (radiation-induced cardiomyopathy, diabetes sepsis-induced cardiac doxorubicin-induced iron overload hypertrophic cardiomyopathy), pulmonary arterial hypertension), involving regulation, metabolic mechanism lipid peroxidation. This article reviews recent research on regulation its relationship with occurrence treatment CVDs, aiming provide ideas targets for clinical diagnosis by clarifying latest progress research. Graphical • The identification, development history characterization ferroptosis. role different subcellular organelles organelle-specific regulators includes metabolism, amino acid metabolism. cardiovascular cells diseases. efficacy pathological involved
Language: Английский
Citations
18
Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 4, 2025
Resveratrol (RES), a natural polyphenolic compound, has garnered significant attention for its therapeutic potential in various pathological conditions. This review explores how RES modulates mitophagy-the selective autophagic degradation of mitochondria essential maintaining cellular homeostasis. promotes the initiation and execution mitophagy by enhancing PINK1/Parkin-mediated mitochondrial clearance, reducing reactive oxygen species production, mitigating apoptosis, thereby preserving integrity. Additionally, regulates through activation key molecular targets such as AMP-activated protein kinase (AMPK), mechanistic target rapamycin (mTOR), deacetylases (SIRT1 SIRT3), quality control (MQC) pathways, demonstrating substantial effects multiple disease models. We provide detailed account biosynthetic pharmacokinetics, metabolic characteristics RES, focusing on role modulation implications medical applications. Potential adverse associated with clinical use are also discussed. Despite promising properties, application is limited issues bioavailability pharmacokinetic profiles. Future research should concentrate developing derivatives that precisely modulate mitophagy, unlocking new avenues therapy.
Language: Английский
Citations
3
Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)
Published: Jan. 28, 2025
Oxidative stress-associated proximal tubular cells (PTCs) damage is an important pathogenesis of hypertensive renal injury. We previously reported the protective effect VEGFR3 in salt-sensitive hypertension. However, specific mechanism underlying role kidney during overactivation renin-angiotensin-aldosterone system remains unclear. In present study, nephropathy was established by angiotensin II (Ang II). found that highly increased PTCs Ang II-infused mice. Activation mitigated dysfunction, pathological damage, and oxidative stress II-induced Moreover, we restored mitophagy deficiency induced both vivo vitro to alleviate injury PTCs. Furthermore, experiment demonstrated improved abnormal enhancing PARKIN mitochondrial translocation. LC-MS/MS Co-IP assays identified HSPA1L as interacted protein VEGFR3, which promoted translocation PARKIN. Mechanistically, disorder domain bound HSPA1L, crotonylation modification at K130 required for regulation context Finally, on were attenuated transfection (HSPA1L-K130R) mutant plasmid vitro. These findings indicated alleviated promoting PARKIN-dependent pathway via regulating site PTCs, provided a mechanistic basis therapeutic target
Language: Английский
Citations
2
Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)
Published: Sept. 19, 2023
A large body of evidence indicates the existence a complex pathophysiological relationship between cardiovascular diseases and cancer. Mitochondria are crucial organelles whose optimal activity is determined by quality control systems, which regulate critical cellular events, ranging from intermediary metabolism calcium signaling to mitochondrial dynamics, cell death mitophagy. Emerging data indicate that impaired drives myocardial dysfunction occurring in several heart diseases, including cardiac hypertrophy, infarction, ischaemia/reperfusion damage metabolic cardiomyopathies. On other hand, diverse human cancers also dysregulate promote their initiation progression, suggesting modulating homeostasis may represent promising therapeutic strategy both cardiology oncology. In this review, first we briefly introduce physiological mechanisms underlying system, then summarize current understanding about impact dysregulated functions We discuss key increased risk complications secondary main anticancer strategies, highlighting potential strategies aimed at alleviating impairment-related tumorigenesis. It hoped summary can provide novel insights into precision medicine approaches reduce cancer morbidities mortalities.
Language: Английский
Citations
33
Basic Research in Cardiology, Journal Year: 2023, Volume and Issue: 118(1)
Published: Nov. 8, 2023
Abstract Cardiovascular disease (CVD) is a major threat to human health, accounting for 46% of non-communicable deaths. Glycolysis conserved and rigorous biological process that breaks down glucose into pyruvate, its primary function provide the body with energy intermediate products needed life activities. The non-glycolytic actions enzymes associated glycolytic pathway have long been found be development CVD, typically exemplified by metabolic remodeling in heart failure, which condition exhibits rapid adaptive response hypoxic conditions, occurring early course failure. It mainly characterized decrease oxidative phosphorylation rise pathway, glycolysis considered hallmark remodeling. In addition this, main source cardiomyocytes during ischemia–reperfusion. Not only that, auxiliary pathways glycolysis, such as polyol hexosamine pentose phosphate are also closely related CVD. Therefore, targeting very attractive therapeutic intervention However, relationship between CVD complex, some preclinical studies confirmed does certain degree efficacy, but specific role has yet explored. This article aims summarize current knowledge regarding key (including hexokinase (HK), phosphoglucose isomerase (PGI), phosphofructokinase-1 (PFK1), aldolase (Aldolase), phosphoglycerate metatase (PGAM), enolase (ENO) pyruvate kinase (PKM) lactate dehydrogenase (LDH)) their cardiovascular diseases (e.g., myocardial infarction, atherosclerosis) possible emerging targets.
Language: Английский
Citations
23
Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(18)
Published: Sept. 1, 2024
Abstract Despite extensive progress in the knowledge and understanding of cardiovascular diseases significant advances pharmacological treatments procedural interventions, (CVD) remain leading cause death globally. Mitochondrial dynamics refers to repetitive cycle fission fusion mitochondrial network. Fission balance regulate shape influence physiology, quality homeostasis. Mitophagy is a process that eliminates aberrant mitochondria. Melatonin (Mel) pineal‐synthesized hormone with range properties. Numerous nonclinical trials have demonstrated Mel provides cardioprotection against ischemia/reperfusion, cardiomyopathies, atherosclerosis cardiotoxicity. Recently, interest has grown how contribute melatonin cardioprotective effects. This review assesses literature on protective effects CVD via regulation mitophagy both in‐vivo in‐vitro studies. The signalling pathways underlying its were reviewed. modulated proteins by upregulation mitofusin, inhibition DRP1 mitophagy‐related proteins. evidence supports role control CVD.
Language: Английский
Citations
9
Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 29, 2024
Mitochondria are energy factories that sustain life activities in the body, and their dysfunction can cause various metabolic diseases threaten human health. Mitophagy, an essential intracellular mitochondrial quality control mechanism, maintain cellular homeostasis by removing damaged mitochondria participating developing diseases. Research has confirmed exercise regulate mitophagy levels, thereby exerting protective effects This article reviews role of diseases, on mitophagy, potential mechanisms exercise-regulated intervention providing new insights for future basic clinical research interventions to prevent treat
Language: Английский
Citations
8
Journal of Clinical Hypertension, Journal Year: 2025, Volume and Issue: 27(2)
Published: Feb. 1, 2025
Abstract To evaluate the prevalence of type 2 diabetes mellitus (T2DM) and hyperlipidemia in hypertensive patients South China assess relationship between these comorbidities blood pressure control to develop targeted strategies for hypertension management. Data from 2020 Guangzhou National Basic Public Health Service Program were analyzed using Chi‐square tests, t ‐tests, logistic regression with R 4.1.2. Among 275,789 patients, rate was 51.51%. The T2DM 12.79%, 12.78% alone, 33.54% 40.89% no comorbidities. Blood rates significantly differed by comorbidity ( p < 0.05): 52.84% those without T2DM/hyperlipidemia, 54.18%, 49.25% or 50.52% both conditions. Multivariate analysis indicated a lower alone (OR = 1.144) 1.082), higher 0.936). Subgroup revealed that males, older age, education, obesity, alcohol use, lack physical activity, poor medication adherence associated rates. This study found high among Guangzhou. Additionally, had poorer compared other diabetic patients. Key factors such as being overweight, unhealthy lifestyle choices impact management this population. Therefore, comprehensive measures should be implemented integrate lipid into community health efforts effectively levels
Language: Английский
Citations
1