Precision Medicine and Precision Nursing: The Era of Biomarkers and Precision Health

International Journal of General Medicine, Journal Year: 2020, Volume and Issue: Volume 13, P. 1705 - 1711

Published: Dec. 1, 2020

Precision health, by means of the support precision medicine and nursing, is able to clinical decision making in order tailor optimal health-care decisions, around individual characteristics patients. The operational arm health represented use biomarkers that can give useful information about disease susceptibility, exposure, evolution response treatment. Omics, imaging are actually studied for their ability positively impact management. In this article, we try address role context modern nursing with view improving patients care.

Language: Английский

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A review on the application of the exposome paradigm to unveil the environmental determinants of age-related diseases

Human Genomics, Journal Year: 2022, Volume and Issue: 16(1)

Published: Nov. 8, 2022

Abstract Age-related diseases account for almost half of all among adults worldwide, and their incidence is substantially affected by the exposome, which sum exogenous endogenous environmental exposures human body’s response to these throughout entire lifespan. Herein, we perform a comprehensive review epidemiological literature determine key elements exposome that affect development age-related roles aging hallmarks in this process. We find most exposure assessments previous studies have used reductionist approach, whereby effect only single factor or specific class factors on has been examined. As such, there lack holistic unbiased understanding multiple diseases. To address this, propose several research strategies based an exposomic framework could advance our understanding—in particular, from mechanistic perspective—of how discuss statistical methods other exposome-wide association studies, with particular focus multiomics technologies. also future challenges opportunities realm multidisciplinary approaches genome–exposome epidemiology. Furthermore, provide perspectives precise public health services vulnerable populations, communications, integration risk information, bench-to-bedside translation

Language: Английский

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Measuring healthy ageing: current and future tools

Biogerontology, Journal Year: 2023, Volume and Issue: 24(6), P. 845 - 866

Published: July 13, 2023

Abstract Human ageing is a complex, multifactorial process characterised by physiological damage, increased risk of age-related diseases and inevitable functional deterioration. As the population world grows older, placing significant strain on social healthcare resources, there growing need to identify reliable easy-to-employ markers healthy for early detection trajectories disease risk. Such would allow targeted implementation strategies or treatments that can lessen suffering, disability, dependence in old age. In this review, we summarise scores reported literature, with focus past 5 years, compare contrast variables employed. The use approaches determine biological age, molecular biomarkers, trajectories, multi-omics are reviewed. We conclude ideal score multisystemic able encompass all potential alterations associated ageing. It should also be longitudinal accurately predict complications at an stage order maximize chances successful intervention.

Language: Английский

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Digging into the intrinsic capacity concept: Can it be applied to Alzheimer’s disease?

Progress in Neurobiology, Journal Year: 2024, Volume and Issue: 234, P. 102574 - 102574

Published: Jan. 22, 2024

Language: Английский

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Progress in the study of aging marker criteria in human populations

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 24, 2024

The use of human aging markers, which are physiological, biochemical and molecular indicators structural or functional degeneration associated with aging, is the fundamental basis individualized assessments. Identifying methods for selecting markers has become a primary vital aspect research. However, there no clear consensus uniform principle on criteria screening markers. Therefore, we combine previous research from our center summarize in population studies, discussed three aspects: perspective, operational implementation perspective methodological perspective. Finally, an evaluation framework been established, categorized into levels based their importance, can help assess extent to candidate biomarker may be feasible, valid, useful specific context.

Language: Английский

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Exploring the conceptual framework and measurement model of intrinsic capacity defined by the World Health Organization: A scoping review

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 80, P. 101685 - 101685

Published: July 10, 2022

WHO has defined intrinsic capacity (IC) as the composite of all physical and mental capacities an individual covering five subdomains: cognition, locomotion, sensory, vitality, psychological. Despite this well accepted definition, conceptual measurement model IC remains unclear, which hampers a standardized operationalization construct. We performed scoping review to give comprehensive overview extent current literature addresses assumes framework reflective or formative. For inclusion, we considered types articles that were published in peer-reviewed journals except for protocol articles. A systematic search 6 databases from different disciplines led inclusion 31 papers. found inconsistency gaps descriptions IC. Most papers did not define model. In background validation articles, identified both formative models while empirical studies applying measurements underlying assumptions remained mainly unclear. Defining is merely theoretical matter but influences processes This study raised questions about most fundamental features construct discusses whether should be latent trait (reflective construct) aggregate summary measure subdomain (formative construct).

Language: Английский

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Phloretin Transfersomes for Transdermal Delivery: Design, Optimization, and In Vivo Evaluation

Molecules, Journal Year: 2023, Volume and Issue: 28(19), P. 6790 - 6790

Published: Sept. 24, 2023

Phloretin (Phl) is a flavonoid compound that contains multiple phenolic hydroxyl groups. It found in many plants, such as apple leaves, lychee pericarp, and begonia, has various biological activities, antioxidant anticancer effects. The strong hydrogen bonding between Phl molecules results poor water solubility low bioavailability, thus the scope of clinical application limited. Therefore, it particularly important to improve for its use further combat or alleviate skin aging oxidative damage develop products skin. purpose this study was evaluate phloretin transfersome gel (PTG) preparation transdermal drug delivery bioavailability delay aging.

Language: Английский

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Impact of the pre-examination phase on multicenter metabolomic studies

New Biotechnology, Journal Year: 2022, Volume and Issue: 68, P. 37 - 47

Published: Jan. 20, 2022

The development of metabolomics in clinical applications has been limited by the lack validation large multicenter studies. Large population cohorts and their biobanks are a valuable resource for acquiring insights into molecular disease mechanisms. Nevertheless, most collections not tailored have created without specific attention to pre-analytical requirements high-quality metabolome assessment. Thus, comparing samples obtained different procedures remains major challenge. Here, 1H NMR-based analyses used demonstrate how human serum plasma collected with operating within several European cohort studies from Biobanking Biomolecular Resources Infrastructure - Prospective Cohorts (BBMRI-LPC) consortium can be easily revealed supervised multivariate statistical at initial stages process, avoid biases downstream analysis. inter-biobank differences discussed terms deviations validated CEN/TS 16945:2016 / ISO 23118:2021 norms. It clearly emerges that must adhere evidence-based guidelines order support wider-scale application biomedicine, NMR spectroscopy is informative quality sample sources multi cohort/center

Language: Английский

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Long-Term Dietary Lycium ruthenicum Murr. Anthocyanins Intake Alleviated Oxidative Stress-Mediated Aging-Related Liver Injury and Abnormal Amino Acid Metabolism

Foods, Journal Year: 2022, Volume and Issue: 11(21), P. 3377 - 3377

Published: Oct. 26, 2022

In recent years, the relationship between Lycium ruthenicum Murr. anthocyanins (LRA) and health has attracted increasing attention. The purpose of this study is to investigate anti-aging effect mechanism LRA through a D-galactose (DG)-induced aging rat model. Our results showed that long-term intake LRA, for 8 weeks, improved motor function, reduced serum markers, promoted endogenous antioxidant system, suppressed inflammatory cytokines in rats. Besides, treatment alleviated DG-induced liver injuries by relieving inflammation inhibiting Fas/FasL-mediated cell death. More importantly, abnormal metabolome profiles rats were restored relating 38 metabolites 44 pathways. Specifically, significantly affected amino acid protein-related metabolic pathways regulating levels L-threonine, L-aspartic acid, glycine, L-histidine, D-homocysteine, L-homocitrulline, L-homoserine, guanidineacetic kynurenine. These have important implications development as an liver-protective ingredient.

Language: Английский

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Revolutionizing multi‐omics analysis with artificial intelligence and data processing

Quantitative Biology, Journal Year: 2025, Volume and Issue: 13(3)

Published: April 7, 2025

Language: Английский

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