Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
22, P. 423 - 452
Published: Oct. 20, 2022
Osteoarthritis
(OA)
is
a
highly
prevalent
whole-joint
disease
that
causes
disability
and
pain
affects
patient's
quality
of
life.
However,
currently,
there
lack
effective
early
diagnosis
treatment.
Although
stem
cells
can
promote
cartilage
repair
treat
OA,
problems
such
as
immune
rejection
tumorigenicity
persist.
Extracellular
vesicles
(EVs)
transmit
genetic
information
from
donor
mediate
intercellular
communication,
which
considered
functional
paracrine
factor
cells.
Increasing
evidences
suggest
EVs
may
play
an
essential
complex
role
in
the
pathogenesis,
diagnosis,
treatment
OA.
Here,
we
introduced
OA
progression
by
influencing
inflammation,
metabolism,
aging.
Next,
discussed
blood,
synovial
fluid,
joint-related
for
diagnosis.
Moreover,
outlined
potential
modified
unmodified
their
combination
with
biomaterials
therapy.
Finally,
discuss
deficiencies
put
forward
prospects
challenges
related
to
application
field
Journal of Inflammation Research,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 1207 - 1233
Published: Jan. 1, 2025
Osteoarthritis
(OA)
affects
several
joints
but
tends
to
be
more
prevalent
in
those
that
are
weight-bearing,
such
as
the
knees,
which
most
heavily
loaded
body.
The
incidence
and
disability
rates
of
OA
have
continued
increase
seriously
jeopardise
quality
life
middle-aged
older
adults.
However,
is
than
just
a
wear
tear
disease;
its
aetiology
complex,
pathogenesis
poorly
understood.
Metabolic
syndrome
(MetS)
has
emerged
critical
driver
development.
This
condition
contributes
formation
distinct
phenotype,
termed
metabolic
syndrome-associated
osteoarthritis
(MetS-OA),which
differs
from
other
metabolically
related
diseases
by
unique
pathophysiological
mechanisms
clinical
presentation.
As
key
mediators
MetS,
adipokines
leptin,
lipocalin,
resistin
regulate
inflammation
bone
metabolism
through
or
synergistic
signaling
pathways.
Their
modulation
inflammatory
responses
remodeling
processes
plays
role
progression
OA.
Due
their
central
regulating
remodeling,
not
only
deepen
our
understanding
MetS-OA
also
represent
promising
targets
for
novel
therapeutic
strategies
could
slow
disease
improve
outcomes
affected
patients.
Pharmacological Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107649 - 107649
Published: Feb. 1, 2025
The
joint
dysfunction
caused
by
osteoarthritis
(OA)
is
increasingly
becoming
a
major
challenge
in
global
healthcare,
and
there
currently
no
effective
strategy
to
prevent
the
progression
of
OA.
Therefore,
better
elucidating
relevant
mechanisms
OA
occurrence
development
will
provide
theoretical
basis
for
formulating
new
prevention
control
strategies.
Due
long-term
exposure
cartilage
tissue
hypoxic
microenvironment
joints,
metabolic
reprogramming
changes
occur.
Hypoxia-inducible
factor-1alpha
(HIF-1α),
as
core
gene
regulating
hypoxia
response
vivo,
plays
an
important
regulatory
role
metabolism
chondrocytes.
HIF-1α
adapts
such
glycolysis,
oxidative
phosphorylation
(OXPHOS),
amino
acid
metabolism,
lipid
In
addition,
also
regulates
macrophage
polarization
synovial
inflammation,
chondrocytes
degeneration
extracellular
matrix
(ECM)
degradation,
subchondral
bone
remodeling
angiogenesis
OA,
affects
pathophysiological
Consequently,
regulation
has
become
therapeutic
target
this
article
reviews
mechanism
affecting
chondrocyte
reprogramming,
focusing
on
summarizes
potential
ingredients
or
targets
targeting
order
more
beneficial
treatment
clinical
drugs.
Stem Cell Research & Therapy,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: July 13, 2021
Abstract
Objectives
Aberrations
in
exosomal
circular
RNA
(circRNA)
expression
have
been
identified
various
human
diseases.
In
this
study,
we
investigated
whether
circRNAs
could
act
as
competing
endogenous
RNAs
(ceRNAs)
to
regulate
the
pathological
process
of
osteoarthritis
(OA).
This
study
aimed
elucidate
specific
MSC-derived
responsible
for
MSC-mediated
chondrogenic
differentiation
using
bone
marrow-derived
MSCs
(hMSCs)
and
a
destabilization
medial
meniscus
(DMM)
mouse
model
OA.
Methods
Exosomal
circRNA
deep
sequencing
was
performed
evaluate
induced
undergo
chondrogenesis
from
day
0
21.
The
regulatory
functional
roles
circRNA_0001236
were
examined
on
21
after
inducing
hMSCs
validated
vitro
vivo.
downstream
target
also
explored
vivo
bioinformatics
analyses.
A
luciferase
reporter
assay
used
interaction
between
miR-3677-3p
well
gene
sex-determining
region
Y-box
9
(
Sox9
).
function
mechanism
OA
DMM
model.
Results
Upregulation
enhanced
Col2a1
but
inhibited
that
MMP13
chondrogenesis.
Moreover,
acted
an
sponge
functioned
chondrocytes
via
targeting
.
Intra-articular
injection
attenuated
Conclusions
Our
results
reveal
important
role
novel
differentiation.
Overexpression
promoted
cartilage-specific
protein
through
miR-3677-3p/Sox9
axis.
Thus,
circRNA_0001236-overexpressing
exosomes
may
alleviate
cartilage
degradation,
suppressing
progression
enhancing
repair.
findings
provide
potentially
effective
therapeutic
strategy
treating
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
22, P. 423 - 452
Published: Oct. 20, 2022
Osteoarthritis
(OA)
is
a
highly
prevalent
whole-joint
disease
that
causes
disability
and
pain
affects
patient's
quality
of
life.
However,
currently,
there
lack
effective
early
diagnosis
treatment.
Although
stem
cells
can
promote
cartilage
repair
treat
OA,
problems
such
as
immune
rejection
tumorigenicity
persist.
Extracellular
vesicles
(EVs)
transmit
genetic
information
from
donor
mediate
intercellular
communication,
which
considered
functional
paracrine
factor
cells.
Increasing
evidences
suggest
EVs
may
play
an
essential
complex
role
in
the
pathogenesis,
diagnosis,
treatment
OA.
Here,
we
introduced
OA
progression
by
influencing
inflammation,
metabolism,
aging.
Next,
discussed
blood,
synovial
fluid,
joint-related
for
diagnosis.
Moreover,
outlined
potential
modified
unmodified
their
combination
with
biomaterials
therapy.
Finally,
discuss
deficiencies
put
forward
prospects
challenges
related
to
application
field
