International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114056 - 114056
Published: Jan. 11, 2025
Language: Английский
Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2024, Volume and Issue: 15(3), P. 1121 - 1133
Published: March 31, 2024
Abstract Background Cytokines and growth factors may serve as a bridge in studying the causal relationships between inflammaging sarcopenia due to their roles inflammaging. In this study, we aim explore association of cytokines with aging traits further identify significant inflammation factors. Methods Bidirectional Mendelian randomization (MR) analysis was used causality. Forty‐one kinds circulation were set exposures, data from summary genome‐wide study (GWAS) containing three cohorts 8293 healthy participants European ancestry 1983 2011. Hand grip strength, adjusted appendicular lean mass (AALM), usual walking pace, moderate‐to‐vigorous physical activity (MVPA) levels, able walk or cycle unaided for 10 min (AWCU10) telomere length selected outcomes. Data outcomes obtained meta‐GWAS UK Biobank, sample sizes ranged 69 537 472 174. Low hand strength defined by Working Group on Sarcopenia Older People (EWGSOP) Foundation National Institutes Health (FNIH) cut‐off points, respectively. Other outcome measured according Biobank raw cohorts' criteria. We two significance thresholds single nucleotide polymorphisms (SNPs) associated exposures obtain adequate SNPs (5 × −6 5 −8 ). Inverse‐variance weighted, MR‐Egger weighted median employed estimate Results Twenty‐seven identified relate causally, most only one trait. IL16 (interleukin‐16), CTACK (cutaneous T‐cell attracting chemokine), MIP1b (macrophage inflammatory protein 1b) PDGFbb (platelet‐derived factor BB) proven causally at least trait both analyses thresholds. (0.977 [0.956–0.998] EWGSOP 0.933 [0.874–0.996] FNIH), AALM (0.991 [0.984, 0.998]), MVPA (0.997 [0.995–1.000]) AWCU10 (1.008 [1.003–1.013]). (1.013 [1.007–1.019] 1.090 [1.041–1.142] (0.990 [0.986–0.994]) (0.998 [0.983–0.994]). The results indicated that has effect (1.032 [1.001–1.063] EWGSOP), (0.994 [0.988–1.000] 0.993 [0.988–0.998]) (1.006 [1.000–1.012]). (1.016 [1.001–1.030]) (1.011 [1.007–1.015]). Reserve MR also proved unidirectional effects. Conclusions related traits, effects IL16, CTACK,
Language: Английский
Citations
8
Geriatrics and gerontology international/Geriatrics & gerontology international, Journal Year: 2025, Volume and Issue: 25(2), P. 139 - 147
Published: Jan. 3, 2025
In this review, we review the current status of biomarkers for aging and possible perspectives on anti‐aging or rejuvenation from standpoint biomarkers. Aging is observed in all cells organs, focused research into senescence skin, musculoskeletal system, immune cardiovascular system. Commonly used include SA‐βgal, cell‐cycle markers, senescence‐associated secretory phenotype (SASP) factors, damage‐associated molecular patterns (DAMPs), DNA‐damage‐related markers. addition, each organ cell has its specific Generally speaking, a combination required to define age‐related changes. When considering translation basic research, that are highly sensitive, specific, with validation reliability as well being non‐invasive optimal; however, currently reported markers do not fulfill prerequisite rodent models necessarily represent human aging, applicable clinical settings. The clinically they provide useful information decision‐making, such predicting disease risk, diagnosing disease, monitoring progression, guiding treatment decisions. Therefore, development robust, reliable, humans necessary develop therapy humans. Geriatr Gerontol Int 2025; 25: 139–147 .
Language: Английский
Citations
1
MedComm, Journal Year: 2025, Volume and Issue: 6(1)
Published: Jan. 1, 2025
Abstract Sarcopenia is defined as a muscle‐wasting syndrome that occurs with accelerated aging, while cachexia severe wasting associated conditions such cancer and immunodeficiency disorders, which cannot be fully addressed through conventional nutritional supplementation. can considered component of cachexia, the bidirectional interplay between adipose tissue skeletal muscle potentially serving molecular mechanism for both conditions. However, underlying mechanisms differ. Recognizing distinctions these disorders essential advancing basic translational research in this area, enhancing diagnostic accuracy ultimately achieving effective therapeutic solutions affected patients. This review discusses microenvironment's changes contributing to conditions, recent approaches like lifestyle modifications, small molecules, interventions, emerging strategies gene editing, stem cell therapy, gut microbiome modulation. We also address challenges opportunities multimodal aiming provide insights into pathogenesis sarcopenia aiding innovative strategy development improved treatments.
Language: Английский
Citations
1
Sports Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract Background Aging is associated with sustained low-grade inflammation, which has been linked to age-related diseases and mortality. Long-term exercise programs have shown be effective for attenuating this process; however, subsequent detraining might negate some of these benefits. Master athletes, as a model lifelong consistent practice, suggested present similar inflammatory profiles untrained young adults. Nonetheless, it unclear whether maintaining training habits throughout life can completely counteract inflammation aging. Objectives We aimed systematically evaluate comparisons baseline in middle-aged older adults, individuals elucidate Methods A systematic review was conducted following the Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) statement, protocol prospectively registered PROSPERO (CRD42024521339). Studies reporting systemic levels proinflammatory anti-inflammatory markers athletes controls were eligible inclusion. total six databases (PubMed [MEDLINE], Embase, Cochrane Central Register Controlled Trials [CENTRAL], Scopus, SPORTDiscus, Web Science [WoS]) searched September 2024, studies independently screened by two reviewers. Risk bias assessed using an adapted version Joanna Briggs Institute Critical Appraisal tool cross-sectional trials, random-effect meta-analyses standardized mean differences (SMDs) between age-matched adults well subjects. Subgroup analyses performed based on intensity type, participants’ sex. Results 17 ( n = 649 participants) included both qualitative quantitative synthesis. Lifelong appears attenuate increases C-reactive protein, elevate interleukin (IL)-10 compared (C-reactive protein: SMD − 0.71, 95% confidence interval 0.97, 0.45, I 2 0%, p 0.78; IL-10: 1.44, 0.55, 2.32, 87%, < 0.00001). Statistical significance maintained protein IL-10 sub-analyses. No difference tumor necrosis factor-α observed (SMD 0.40, 0.15, 0.96, 72%, 0.0008). trend towards decreased IL-6 pooled comparing rendered statistically significant However, indicated that still elevated IL-6, along IL-10. Conclusions exhibit more profile denoted circulating and, potentially, increased healthy peers. insufficient changes factor-α, IL-10,
Language: Английский
Citations
1
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114056 - 114056
Published: Jan. 11, 2025
Language: Английский
Citations
1