Mitigating cellular aging and enhancing cognitive functionality: visual arts-mediated Cognitive Activation Therapy in neurocognitive disorders DOI Creative Commons
Manuela Campisi, Luana Cannella, Dilek Celik

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: March 8, 2024

The growing phenomenon of population aging is redefining demographic dynamics, intensifying age-related conditions, especially dementia, projected to triple by 2050 with an enormous global economic burden. This study investigates visual arts-mediated Cognitive Activation Therapy (CAT) as a non-pharmacological CAT intervention targets both biological [leukocyte telomere length (LTL), DNA methylation age (DNAmAge)] and cognitive functionality. Aligning broader trend integrating approaches into dementia care. longitudinal involved 20 patients mild moderate neurocognitive disorders. functional assessments, markers -i.e., LTL DNAmAge- were analyzed before after intervention. Change in was positively correlated days treatment ( p =0.0518). significantly elongated =0.0269), men =0.0142), correlating younger =0.0357), higher education =0.0008). DNAmAge remained instead stable post-treatment. improvements observed for Copy complex geometric figure, Progressive Silhouettes, Position Discrimination, Communication Activities Daily Living—Second edition, Direct Functional Status < 0.0001) Object decision =0.0594), but no correlations found between gains. Visual effectively mitigates cellular aging, men, elongating LTL. These findings underscore the potential interventions enhancing status general well-being Further research larger longer-term studies essential validation.

Language: Английский

Accelerated biological aging as a potential risk factor for rheumatoid arthritis DOI
Yi‐Lin Dan,

Yiqun Yang,

Dongcheng Zhu

et al.

International Journal of Rheumatic Diseases, Journal Year: 2024, Volume and Issue: 27(4)

Published: April 1, 2024

Abstract Objects Previous studies have suggested a potential correlation between rheumatoid arthritis (RA) and biological aging, but the intricate connections mechanisms remain elusive. Methods In our study, we focused on two specific measures of age (PhenoAge BioAge), which are derived from clinical biomarkers. The residuals these measures, when compared to chronological age, defined as accelerations (BAAs). Utilizing extensive UK Biobank dataset along with various genetic datasets, conducted thorough assessment relationship BAAs RA at both individual aggregate levels. Results Our observational revealed positive correlations risk developing seropositive RA. Furthermore, score (GRS) for PhenoAgeAccel was associated an increased Linkage disequilibrium regression (LDSC) analysis further supported findings, revealing PLACO identified 38 lead pleiotropic single nucleotide polymorphisms linked 301 genes, providing valuable insights into connecting Conclusion summary, study has successfully accelerated measured by BAAs, susceptibility

Language: Английский

Citations

3
Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease DOI Creative Commons
Blanca Rodríguez‐Fernández, Gonzalo Sánchez‐Benavides, Patricia Genius

et al.

Neurobiology of Aging, Journal Year: 2024, Volume and Issue: 141, P. 140 - 150

Published: June 1, 2024

Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL cognitive performance middle-aged cognitively unimpaired individuals increased risk AD. A total 1,520 participants from ALFA cohort were included. Relative was measured leukocytes through qPCR. residualized against age sex, associations with assessed short long groups based on (rLTL). Interactions sex genetic AD tested. Non-linear found episodic memory (EM). Better EM associated longer rLTL among women group. Results suggest potential telomeres aging process sex-specific patterns.

Language: Английский

Citations

3
The brain-protective mechanism of fecal microbiota transplantation from young donor mice in the natural aging process via exosome, gut microbiota, and metabolomics analyses DOI Creative Commons
Longfei Lin,

Ruying Tang,

Yuling Liu

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 207, P. 107323 - 107323

Published: July 23, 2024

The natural aging process is accompanied by changes in exosomes, gut microbiota, and metabolites. This study aimed to reveal the anti-aging effect mechanisms of fecal microbiota transplantation (FMT) from young donors on mice analyzing metabolomics. Aging-relevant telomeric length, oxidative stress indexes brain tissue, serum cytokine levels were measured. Flow analysis T-regulatory (Treg), CD4

Language: Английский

Citations

3
Causal Relationship between Aging and Anorexia Nervosa: A White-Matter-Microstructure-Mediated Mendelian Randomization Analysis DOI Creative Commons

Haoyuan Qiu,

Miao Shi,

Zicheng Zhong

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1874 - 1874

Published: Aug. 16, 2024

This study employed a two-step Mendelian randomization analysis to explore the causal relationship between telomere length, as marker of aging, and anorexia nervosa evaluate mediating role changes in white matter microstructure across different brain regions. We selected genetic variants associated with 675 diffusion magnetic resonance imaging phenotypes representing matter. F-statistics confirmed validity instruments, ensuring robust inference. Sensitivity analyses, including heterogeneity tests, horizontal pleiotropy leave-one-out validated results. The results show that length is significantly negatively correlated unidirectional manner (

Language: Английский

Citations

3
Mitigating cellular aging and enhancing cognitive functionality: visual arts-mediated Cognitive Activation Therapy in neurocognitive disorders DOI Creative Commons
Manuela Campisi, Luana Cannella, Dilek Celik

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: March 8, 2024

The growing phenomenon of population aging is redefining demographic dynamics, intensifying age-related conditions, especially dementia, projected to triple by 2050 with an enormous global economic burden. This study investigates visual arts-mediated Cognitive Activation Therapy (CAT) as a non-pharmacological CAT intervention targets both biological [leukocyte telomere length (LTL), DNA methylation age (DNAmAge)] and cognitive functionality. Aligning broader trend integrating approaches into dementia care. longitudinal involved 20 patients mild moderate neurocognitive disorders. functional assessments, markers -i.e., LTL DNAmAge- were analyzed before after intervention. Change in was positively correlated days treatment ( p =0.0518). significantly elongated =0.0269), men =0.0142), correlating younger =0.0357), higher education =0.0008). DNAmAge remained instead stable post-treatment. improvements observed for Copy complex geometric figure, Progressive Silhouettes, Position Discrimination, Communication Activities Daily Living—Second edition, Direct Functional Status < 0.0001) Object decision =0.0594), but no correlations found between gains. Visual effectively mitigates cellular aging, men, elongating LTL. These findings underscore the potential interventions enhancing status general well-being Further research larger longer-term studies essential validation.

Language: Английский

Citations

2