Gut microbiota-host lipid crosstalk in Alzheimer’s disease: implications for disease progression and therapeutics

Molecular Neurodegeneration, Journal Year: 2024, Volume and Issue: 19(1)

Published: April 16, 2024

Abstract Trillions of intestinal bacteria in the human body undergo dynamic transformations response to physiological and pathological changes. Alterations their composition metabolites collectively contribute progression Alzheimer’s disease. The role gut microbiota disease is diverse complex, evidence suggests lipid metabolism may be one potential pathways. However, mechanisms that mediate pathology remain unclear, necessitating further investigation for clarification. This review highlights current understanding how disrupts discusses implications these discoveries guiding strategies prevention or treatment based on existing data.

Language: Английский

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Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: March 16, 2023

There is a close relationship between Alzheimer's disease (AD) and diabetes mellitus (DM), the link two often referred to as type 3 (T3DM). Many natural bioactive compounds have shown potential treat AD diabetes. We mainly review polyphenols represented by resveratrol (RES) proanthocyanidins (PCs) alkaloids berberine (BBR) Dendrobium nobile Lindl. (DNLA) from perspective of T3DM neuroprotective effects molecular mechanisms in AD.

Language: Английский

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Restoration of metal homeostasis: a potential strategy against neurodegenerative diseases

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 87, P. 101931 - 101931

Published: April 8, 2023

Language: Английский

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Impact of Nut Consumption on Cognition across the Lifespan

Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 1000 - 1000

Published: Feb. 16, 2023

Cognitive health is a life-long concern affected by modifiable risk factors, including lifestyle choices, such as dietary intake, with serious implications for quality of life, morbidity, and mortality worldwide. In addition, nuts are nutrient-dense food that contain number potentially neuroprotective components, monounsaturated polyunsaturated fatty acids, fiber, B-vitamins, non-sodium minerals, highly bioactive polyphenols. However, increased nut consumption relates to lower cardiovascular burden factors shared neurodegenerative disorders, which why have been hypothesized be beneficial brain health. The present narrative review discusses up-to-date epidemiological, clinical trial, mechanistic evidence the effect exposure on cognitive performance. While limited inconclusive, available suggests possible role in maintenance prevention decline individuals across lifespan, particularly older adults those at higher risk. Walnuts, rich source plant-based omega-3 acid alpha-linolenic acid, type most promising Given definitive date, especially regarding biomarkers hard outcomes, future studies needed better elucidate impact health, well management dementia, Alzheimer disease.

Language: Английский

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Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol

Cell & Bioscience, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 13, 2023

Abstract Amyloid β is considered a key player in the development and progression of Alzheimer’s disease (AD). Many studies investigating effect statins on lowering cholesterol suggest that there may be link between levels AD pathology. Since one most abundant lipid molecules, especially brain tissue, it affects membrane-related processes, including formation dangerous form amyloid β, Aβ42. The entire Aβ production system, which includes precursor protein (APP), β-secretase, complex γ-secretase, highly dependent membrane content. Moreover, can affect amyloidogenesis many ways. Cholesterol influences stability activity secretases, but also dictates their partitioning into specific cellular compartments cholesterol-enriched rafts, where amyloidogenic machinery predominantly localized. complicated relationships have been found interaction APP, not only APP localization precise character dimerization processing by important for different lengths . In this review, we describe intricate web interdependence levels, distribution, cholesterol-dependent Aβ, major AD.

Language: Английский

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Clinical and neuroimaging association between neuropsychiatric symptoms and nutritional status across the Alzheimer's disease continuum: a longitudinal cohort study

The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(3), P. 100182 - 100182

Published: Feb. 9, 2024

To investigate the association between neuropsychiatric symptoms (NPS) and nutritional status, explore their shared regulatory brain regions on Alzheimer's disease (AD) continuum. A longitudinal, observational cohort study. Data were collected from Chinese Imaging, Biomarkers, Lifestyle study June 1, 2021 December 31, 2022. Overall, 432 patients AD continuum, including amnestic mild cognitive impairment dementia, assessed at baseline, only 165 completed (10.37 ± 6.08) months' follow-up. The Mini-Nutritional Assessment (MNA) Neuropsychiatric Inventory (NPI) used to evaluate status NPS, respectively. corrected cerebral blood flow (cCBF) measured by pseudo-continuous arterial spin labeling of dietary nutrition-related was analyzed. NPS baseline subsequent change in changes severity examined using generalized linear mixed models. Increased cCBF left putamen associated with malnutrition, general affective symptoms, hyperactivity (P < 0.05). presence (β = −1.317, P 0.003), −1.887, 0.001), appetite/eating disorders −1.714, 0.001) a decline MNA scores during higher NPI −0.048), −0.181), −0.416; all longitudinally lower after adjusting for confounding factors. We found that predictors worse disorders, poorer status. Furthermore, abnormal perfusion may regulate malnutrition which suggests potentially common neural basis.

Language: Английский

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Malnutrition exacerbating neuropsychiatric symptoms on the Alzheimer's continuum is relevant to the cAMP signaling pathway: Human and mouse studies

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract INTRODUCTION Malnutrition correlates with neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD); however, the potential mechanism underlying this association remains unclear. METHODS Baseline and longitudinal associations of nutritional status NPSs were analyzed 374 patients on AD continuum 61 healthy controls. Serum biomarkers, behavioral tests, cerebral neurotransmitters, differentially gene expression evaluated standard malnourished diet–fed transgenic APPswe/PSEN1dE9 (APP/PS1) mice. RESULTS Poor increased blood flow midbrain striatum associated severe general subtypes, especially depression, anxiety, apathy. APP/PS1 mice fed a diet showed poor status, depression‐ anxiety‐like behaviors, altered neurotransmitter levels, downregulated c‐Fos striatum; these suppressed cyclic adenosine monophosphate (cAMP) signaling pathway. DISCUSSION exacerbating is relevant to cAMP pathway striatum, suggesting for targeted interventions mitigate continuum. Highlights linked specific symptom (NPS) deterioration. affects NPSs, usually involving striatum. Malnourished induces behaviors exacerbates

Language: Английский

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Lifestyle factors and plasma biomarkers of Alzheimer's disease: A narrative review

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100130 - 100130

Published: March 1, 2025

Alzheimer's disease (AD) is a neurodegenerative disorder characterised by amyloid-β (Aβ), tau hyperphosphorylation and neurodegeneration. Blood-based biomarkers are emerging as minimally invasive tool for detection monitoring. This review depicts the relationships between modifiable lifestyle factors (nutrition, physical activity (PA), sleep, alcohol consumption, smoking, social isolation) plasma of AD: Aβ42, Aβ40, Aβ42/40, phosphorylated tau, total neurofilament light chain (NfL) glial fibrillary acidic protein. Limited evidence suggests that better nutrition associated with favourable AD biomarker profiles PA less NfL Aβ, whilst poor sleep elevated Aβ. However, lack data inconsistent findings highlight need further investigation to substantiate or refute these trends. Moreover, future research should include analysis on according gender, metabolic health APOE status. Considering growing emphasis preventing delaying dementia onset justified.

Language: Английский

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Associations of moderate alcohol intake with cerebrospinal fluid biomarkers of Alzheimer’s disease: data from the ALBION study

European Journal of Nutrition, Journal Year: 2025, Volume and Issue: 64(3)

Published: April 1, 2025

According to a WHO statement, it has been asserted that there is no safe level of alcohol consumption regarding human health. Nevertheless, the relationship between and Alzheimer's disease (AD) pathology remains unclear. Therefore, we examined whether frequency patterns could predict neurodegeneration biomarkers in cohort middle-aged adults without dementia. A total 195 participants dementia were included from ALBION study. Multivariate logistic regression analyses conducted using drinking subgroups (abstainers, occasional drinkers, light-to-moderate drinkers) Mediterranean-Alcohol Dietary Pattern (MADP) adherence along with cerebrospinal fluid (CSF) AD (Tau, phosphorylated tau (PTau) amyloid beta (Aβ). In these analyses, abstinence was used as reference category. Of individuals dementia, 66% female, an average age 65 ± 9.4 years, they had 13.8 3.6 years education. Logistic revealed drinkers (n = 51) associated higher Aβ positivity [OR: 2.98 (1.29-6.90)] compared 117). Additionally, high MADP significantly Aβ, Tau/Aβ42, PTau/Aβ42 ratios abstinence. Light-to-moderate intake deposition High MADP, which indicates low-to-moderate red wine distributing over week meals, Tau/Aβ PTau/Aβ positivity. management may help improve outcomes even at preclinical stage.

Language: Английский

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POLYPHENOLS: STRUCTURE, BIOLOGICAL ACTIVITY, AND ANALYTICAL METHODS

Biosafety and Biotechnology, Journal Year: 2025, Volume and Issue: 21, P. 44 - 58

Published: April 2, 2025

This article examines polyphenolic compounds, their structure and biological activity, as well modern methods for analyzing polyphenols in the fruits of a new cultivated variety jujube Zyzyphus jujuba Mill called “Konfetny” (“Candy”). Polyphenols possess antioxidant, anti-inflammatory, antimicrobial properties, making them promising use food pharmaceutical industries. The reviews analytical techniques such spectrophotometry, chromatography, electrochemical used qualitative quantitative analysis polyphenols. presented findings highlight importance these compounds human health potential development functional foods products.

Language: Английский

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