Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 13, P. 100543 - 100543
Published: Nov. 6, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: June 21, 2024
The drug development process is poised for significant transformation due to the rapid advancement of modern biological and information technologies, such as artificial intelligence (AI). As these new technologies concepts infiltrate every stage development, efficiency success rate research are expected improve substantially. Traditional Chinese medicine (TCM), a time-honored therapeutic system encompassing herbal medicine, acupuncture, qigong, will also be profoundly impacted by advancements. Over next decade, encounter both opportunities challenges it integrates with concepts. By 2035, TCM anticipated merge through more contemporary open model, providing substantial support treating broader spectrum diseases.
Language: Английский
Citations
8
Current Topics in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(19), P. 1683 - 1698
Published: April 27, 2024
: Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disorder (ND), affecting more than 44 million individuals globally as 2023. It characterized by cognitive dysfunction and an inability to perform daily activities. The progression AD associated with accumulation amyloid beta (Aβ), formation neurofibrillary tangles (NFT), increased oxidative stress, neuroinflammation, mitochondrial dysfunction, endoplasmic reticulum stress. Presently, various phytomedicines their bioactive compounds have been identified for neuroprotective effects in reducing alleviating mitigating Aβ acetylcholinesterase enzymes hippocampus cerebral cortex regions brain. However, despite demonstrating promising anti-Alzheimer's effects, clinical utilization phytoconstituents remains limited scope. key factor contributing this limitation challenges inherent traditional drug delivery systems, which impede effectiveness efficiency. These difficulties encompass insufficient targeting, restricted solubility stability, brief duration action, a lack control over release. Consequently, these constraints result diminished bioavailability permeability across blood-brain barrier (BBB). In response challenges, novel systems (NDDS) founded on nanoformulations emerged hopeful strategy augment BBB poor solubility. Among nanoemulsion (NE) extensively investigated potential targeting AD. NE offers several advantages, such ease preparation, high loading, stability. Due nanosize droplets, also improves gut leading enhanced systemic circulation Various studies reported testing NE-based bioactives different animal species, including transgenic, Wistar, Sprague-Dawley (SD) rats, well mice. transgenic mice are commonly employed research analyze Aβ. review, aspects role phytoconstituents, conventional delivery, need NDDS, particularly NE, discussed. involving phytoconstituent-based treatment
Language: Английский
Citations
5
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 788 - 788
Published: June 16, 2024
The COVID-19 pandemic, caused by infection with the SARS-CoV-2 virus, is associated cognitive impairment and Alzheimer’s disease (AD) progression. Once it enters brain, virus stimulates accumulation of amyloids in brain that are highly toxic to neural cells. These may trigger neurological symptoms COVID-19. meningeal lymphatic vessels (MLVs) play an important role removal toxins mediate viral drainage from brain. MLVs considered a promising target prevent COVID-19-exacerbated dementia. However, there limited methods for augmentation MLV function. This review highlights new discoveries field COVID-19-mediated amyloid development strategies stimulate clearance through other pathways. based on innovative treating dysfunction induced infection, including use photobiomodulation, plasmalogens, medicinal herbs, which offer hope addressing challenges posed virus.
Language: Английский
Citations
5
Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Background Type 2 diabetes mellitus (T2D) and Alzheimer's disease (AD) are two prevalent chronic diseases that pose significant global health challenges. Increasing evidence suggests a complex bidirectional relationship between these conditions, where T2D elevates the risk of AD, AD exacerbates glucose metabolism abnormalities in T2D. Objective This review explores molecular mechanisms linking focusing on role insulin signaling pathways oxidative stress. Methods A comprehensive literature search from PubMed, Web Science, other relevant databases was conducted analyzed. Results Insulin resistance leads to impaired brain, contributing cognitive decline development AD. Hyperglycemia-induced stress neuronal damage, promoting formation amyloid-β plaques neurofibrillary tangles characteristic Clinically antidiabetic drugs such as metformin show potential against preclinical studies; Many natural products Dendrobium nobile Lindl. have anti-T2D efficacy also effective various vivo vitro models. Conclusions Improving reducing important strategies treatment To understand bridging singling will provide insights broader applications alleviating
Language: Английский
Citations
0
Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)
Published: Feb. 18, 2025
Abstract Abnormal glucose metabolism inevitably disrupts normal neuronal function, a phenomenon widely observed in Alzheimer’s disease (AD). Investigating the mechanisms of metabolic adaptation during progression has become central focus research. Considering that impaired is closely related to decreased insulin signaling and resistance, new concept "type 3 diabetes mellitus (T3DM)" been coined. T3DM specifically refers brain’s neurons becoming unresponsive insulin, underscoring strong link between AD. Recent studies reveal brain exhibit mitochondrial dysfunction, reduced metabolism, elevated lactate levels. These findings suggest caused by may lead compensatory shift toward glycolysis. Consequently, this review aims explore underlying causes elucidate how resistance drives reprogramming AD progression. Additionally, it highlights therapeutic strategies targeting sensitivity function as promising avenues for successful development treatments.
Language: Английский
Citations
0
British Journal of Nursing, Journal Year: 2025, Volume and Issue: 34(4), P. 202 - 206
Published: Feb. 19, 2025
Language: Английский
Citations
0
Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2025, Volume and Issue: unknown, P. 130789 - 130789
Published: March 1, 2025
Language: Английский
Citations
0
CABI eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 61 - 79
Published: March 24, 2025
Language: Английский
Citations
0
CABI eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 100 - 117
Published: March 24, 2025
Citations
0
Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107574 - 107574
Published: April 1, 2025
Language: Английский
Citations
0