Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 9, 2025

Abstract It remains unclear whether the benefits of adhering to a healthy lifestyle outweigh effects high genetic risk on cognitive decline. We examined association combined factors and with changes in function six specific dimensions cognition among older adults from Chinese Longitudinal Healthy Longevity Survey (1998–2018, n = 18,811, subset 6301 participants information). Compared an unfavorable lifestyle, those favorable showed 46.81% slower rate decline, similar results across most domains. High was associated 12.5% faster Individuals have decline than low lifestyle. These data suggest that factors, therefore may offset for accelerated

Language: Английский

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Searching for responders to multidomain dementia prevention in late life: A pooled analysis of individual participant data from the MAPT and preDIVA trials

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Abstract INTRODUCTION It is unknown in which, if any, subgroups of older adults multidomain interventions are effective at reducing long‐term dementia incidence. METHODS We pooled up to 12 years follow‐up data from 5205 participants aged > 70 the Multidomain Alzheimer Preventive Trial (MAPT) and Prevention Dementia by Intensive Vascular Care (preDIVA) studies. The primary outcome was incident all‐cause dementia. Pre‐specified were defined risk factors (age, sex, education, apolipoprotein E [ APOE ] genotype, cognitive status, cardiovascular factors). RESULTS Four hundred eighty‐six developed during 37,782 person‐years follow‐up. Higher incidence associated with baseline age, ε4 physical inactivity, Mini‐Mental State Examination, blood pressure. intervention had no effect on overall (hazard ratio = 0.98, 95% confidence interval 0.80–1.21), or any pre‐specified subgroup. A recursive partitioning algorithm also did not detect subgroups, single multiple factors, showing a differential effect. DISCUSSION identify whom significantly reduced CLINICAL TRIAL REGISTRATION MAPT: NCT00672685 (clinicaltrials.gov); PreDIVA: ISRCTN29711771 (ISRCTN registry) Highlights two prevention trials. Five thousand five ≥ included. Subgroups pre‐defined modifiable non‐modifiable factors. data‐driven used. lower

Language: Английский

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Tailoring implementation strategies for the healthy actions and lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia Program: Lessons learned from a survey study

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100053 - 100053

Published: Jan. 1, 2025

Language: Английский

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Mediation of modifiable risk factors in two multidomain dementia prevention trials

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract INTRODUCTION We explored which dementia risk factors in two multidomain prevention trials mediate beneficial, neutral, or counteracting effects on incidence. METHODS pooled data from the MAPT (Multidomain Alzheimer Preventive Trial; n = 1679, up to 5‐year follow‐up) and preDIVA (Prevention of Dementia by Intensive Vascular Care; 3526, 12‐year adults aged 70+. used multiple mediation analysis quantify role 2‐year changes body mass index, systolic blood pressure, total cholesterol, physical activity intervention Mixed linear Cox proportional hazard models were explore pathways. RESULTS observed no individual effect interventions The slightly lowered only but this did not translate into an DISCUSSION In older populations, may sufficiently affect lower incidence, particularly settings where cardiovascular factor management is well implemented. Highlights There mediating change incidence large randomized controlled trials. lack explains absence impact dementia. Counteracting mediators do explain A small pressure a

Language: Английский

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Adherence and intensity in multimodal lifestyle-based interventions for cognitive decline prevention: state-of-the-art and future directions

Alzheimer s Research & Therapy, Journal Year: 2025, Volume and Issue: 17(1)

Published: March 17, 2025

Abstract Preventing dementia and Alzheimer’s disease (AD) is a global priority. Multimodal interventions targeting several risk factors mechanisms simultaneously are currently being tested worldwide under the World-Wide FINGERS (WW-FINGERS) network of clinical trials. Adherence to these crucial for their success, yet there significant heterogeneity in adherence reporting across studies, hindering understanding barriers facilitators. This article narrative review available evidence from multimodal prevention A literature search was conducted using medical databases (MEDLINE via PubMed SCOPUS) select relevant studies: nonpharmacological (i.e., combining three or more intervention domains), individuals without dementia, changes cognitive performance and/or incident mild impairment as primary outcomes. Based on findings, we propose future encompass both participation (average attendance each component) lifestyle change scores (e.g., LIBRA index). Moreover, provide an estimation expected intensity interventions, defined ratio dose overall amount offered specified trial protocol) duration (in months). Adjusting by average enables observed intensity, which could be informative identifying optimal dosage thresholds that maximize benefits different populations. Finally, this provides overview determinants emphasizing need improved inform design implementation precision interventions.

Language: Английский

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Alzheimer disease seen through the lens of sex and gender

Nature Reviews Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Language: Английский

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Exploring Older Adults’ Pre-Intervention Motivations, Attitudes, Expectations, and Barriers to Participation in the FINGER-NL Lifestyle Intervention to Maintain Optimal Cognitive Functioning: A Qualitative Interview Study

Ageing International, Journal Year: 2025, Volume and Issue: 50(2)

Published: April 26, 2025

Abstract Multidomain lifestyle interventions hold promise for preventing cognitive decline, but personalized approaches are essential (maintaining) behaviour change and adherence. The Dutch FINGER-NL trial is based on the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment Disability (FINGER) includes 7 intervention components, supported by technological elements. This study describes older adults’ motivations attitudes regarding participation changes at start of trial. followed a qualitative descriptive design, using in-depth, semi-structured interviews with 40 purposively selected participants Thematic analysis was applied. For theme (1) 'Reasons participate', most mentioned personal gain, aiming improve physical health. Dementia prevention key motivator, driven concerns about ageing, desire behavioural change. Public interest contributing broader societal solution were also mentioned. Knowledge dementia (prevention) limited, perceptions largely shaped experiences close ones. In (2) 'Contextual factors influencing participation' discussed, including work, living situation, health conditions. According participants, main 'Lifestyle-related areas improvement', (3), diet activity, lesser extent cognition, sleep, social activities, stress management. Theme (4) 'Expectations FINGER-NL' discussed barriers which included time constraints, established habits, financial limitations. Participants emphasized need counselling, coaching in exercise, experiencing positive effects change, group setting practical aspects, such as appointment reminders support their commitment adherence study. held different opinions 'Use technology', (5). Personal strongly influenced motivation participate FINGER-NL, creating urgency expressed wish receive tailored addressing individual needs circumstances. Longitudinal follow-up within promises valuable insights future interventions.

Language: Английский

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Exercise as medicine for the brain: moving towards precise and personalised recommendations

British Journal of Sports Medicine, Journal Year: 2024, Volume and Issue: 58(13), P. 693 - 695

Published: April 30, 2024

Language: Английский

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Novelties on Neuroinflammation in Alzheimer’s Disease–Focus on Gut and Oral Microbiota Involvement

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11272 - 11272

Published: Oct. 19, 2024

Recent studies underscore the role of gut and oral microbiota in influencing neuroinflammation through microbiota–gut–brain axis, including Alzheimer’s disease (AD). This review aims to provide a comprehensive synthesis recent findings on involvement neuroinflammatory processes associated with AD, emphasizing novel insights therapeutic implications. reveals that dysbiosis AD patients’ is linked heightened peripheral central inflammatory responses. Specific bacterial taxa, such as Bacteroides Firmicutes gut, well Porphyromonas gingivalis cavity, are notably altered leading significant changes microglial activation cytokine production. Gut alterations increased intestinal permeability, facilitating translocation endotoxins like lipopolysaccharides (LPS) into bloodstream exacerbating by activating brain’s toll-like receptor 4 (TLR4) pathways. Furthermore, microbiota-derived metabolites, short-chain fatty acids (SCFAs) amyloid peptides, can cross blood-brain barrier modulate While microbial amyloids may contribute amyloid-beta aggregation brain, certain SCFAs butyrate exhibit anti-inflammatory properties, suggesting potential avenue mitigate neuroinflammation. not only highlights critical pathology but also offers ray hope modulating could represent strategy for reducing slowing progression.

Language: Английский

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How Modifiable Are Modifiable Dementia Risk Factors? A Framework for Considering the Modifiability of Dementia Risk Factors

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 1, 2023

Many risk factors for dementia, identified from observational studies, are potentially modifiable. This raises the possibility that targeting key modifiable dementia may reduce prevalence of which has led to development reduction and prevention strategies, such as intervention trials or guidelines. However, what rarely been considered in studies inform these strategies is extent can (1) be by individuals, (2) readily modified individuals. Characteristics readiness identification targeting, well when they should targeted, influence design, success reducing risk. review aims develop a framework classifying degree modifiability research studies. The could an individual seeking their determined, resources might needed both factor modification, whether modification optimal early-life (aged <45 years), midlife 45–65 years) late-life >65 years). Finally, barriers ability engage and, ultimately, discussed.

Language: Английский

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