Predicting the Beneficial Effects of Cognitive Stimulation and Transcranial Direct Current Stimulation in Amnestic Mild Cognitive Impairment with Clinical, Inflammation, and Human Microglia Exposed to Serum as Potential Markers: A Double-Blind Placebo-Controlled Randomized Clinical Trial

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1754 - 1754

Published: Feb. 19, 2025

In amnestic mild cognitive impairment (aMCI), neuroinflammation evolves during disease progression, affecting microglial function and potentially accelerating the pathological process. Currently, no effective treatment exists, leading to explorations of various symptomatic approaches, though few target underlying physiological mechanisms. Modulating inflammatory processes may be critical in slowing progression. Cognitive stimulation (CS) transcranial direct current (tDCS) applied left dorsolateral prefrontal cortex (l-DLPFC) show promise, but results are heterogeneous. Thus, a randomized, double-blind, placebo-controlled clinical trial is currently underway. The first-stage were examined after three weeks intervention two groups: active tDCS combined with CS sham CS. Twenty-two participants underwent assessments: T0 (baseline) T1 (after 15 sessions tDCS, or sham, 9 CS). demonstrated that improved cognition, increased brain-derived neurotrophic factor (BDNF) levels, reduced peripheral proinflammatory cytokine levels (interleukin IL-6 chemokine CX3CL1) serum. This decrease promote proliferation survival as modulatory effect response, while increase BDNF might suggest regulatory mechanism microglia-neuron interaction responses. However, did not enhance effects CS, suggesting longer interventions required achieve substantial benefits.

Language: Английский

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Prevalence, deaths and disability-adjusted life years due to Alzheimer’s disease and other dementias in Middle East and North Africa, 1990–2021

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 27, 2025

Alzheimer's disease (AD) ranks among the leading causes of morbidity and mortality worldwide. The objective was to evaluate burden AD other dementias countries Middle East North Africa (MENA) region by age sex from 1990 2021. data were sourced Global Burden Disease (GBD) study estimates are presented as counts age-standardised rates per 100,000 accompanied 95% uncertainty intervals (UIs). In 2021, recorded an prevalence 772.7 in MENA (95% UI 671.2–877.6 100,000). This rate decreased 4.9% comparison 1990, marking a statistically significant change. also accounted for approximately 73.79 thousand deaths with decreasing 8.6% compared 1990. Moreover, disability-adjusted life years (DALY) 476.3 population 225.6–1004.2), representing 7.7% decrease Lebanon registered highest point at 828.25, while United Arab Emirates lowest 652.43. 2021 13 countries, no changes observed eight countries. Additionally, women experienced higher rates, DALYs, men. region, dementia rose both sexes. has but it remains than global estimates. Furthermore, findings indicate that imposes greater on female males. To achieve more accurate estimation dementias, systematic studies low- middle-income within required.

Language: Английский

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Associations between multidomain modifiable dementia risk factors with AD biomarkers and cognition in middle-aged and older adults

Neurobiology of Aging, Journal Year: 2024, Volume and Issue: 138, P. 63 - 71

Published: March 2, 2024

This study aimed to determine associations between modifiable dementia risk factors (MDRF), across domains mood symptomatology, lifestyle behaviors, cardiovascular conditions, cognitive/social engagement, sleep disorders/symptomatology, with cognition, beta-amyloid (Aβ) and tau, brain volume. Middle-aged/older adults (n=82) enrolled in a sub-study of the Healthy Brain Project completed self-report questionnaires neuropsychological battery. Cerebrospinal fluid levels Aβ 1-42, total tau (t-tau), phosphorylated (p-tau

Language: Английский

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The Social and Cognitive Online Training (SCOT) project: A digital randomized controlled trial to promote socio-cognitive well-being in older adults

Archives of Gerontology and Geriatrics, Journal Year: 2024, Volume and Issue: 122, P. 105405 - 105405

Published: March 5, 2024

Objectives: Effective prevention programs targeting risk factors for cognitive decline in the elderly are recommended given progressive increase ageing of general population. The Social and Cognitive Online Training (SCOT) project is a randomized, controlled, parallel clinical trial designed to prevent age-related executive social functions. Methods: study included 60 cognitively healthy older adults (age=71.8±5.3, education=12.3±3.7, MoCA=25.1±2.4). Participants underwent baseline neuropsychological assessment were then assigned either an experimental group or non-specific training (CON). Both 8-week digital interventions two individual sessions one meeting per week. Post-intervention evaluated efficacy on specific outcome measures: Tower London functioning, Ekman-60 Faces test, Mini-Social cognition & Emotional Assessment battery cognition. A measure loneliness was as exploratory outcome. Results: Baseline demographic characteristics balanced between SCOT (n=29) CON (n=28) groups. Pre-post-intervention analyses showed improvements functioning both groups, without significant interaction effects. Exploratory post-hoc stratifying by performance post-training emotion recognition, theory mind high-performing participants. Discussion: Results provide preliminary evidence beneficial effects training, particularly those who performed best during training. could represent new intervention promote socio-cognitive well-being context active dementia prevention.

Language: Английский

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Subclinical hyperthyroidism and the risk of dementia: A meta‐analysis

Brain and Behavior, Journal Year: 2024, Volume and Issue: 14(9)

Published: Sept. 1, 2024

Abstract Background Accumulating evidence suggests that thyroid dysfunction may be related to the risk of dementia. However, previous studies evaluating association between subclinical hyperthyroidism and dementia showed inconsistent results. This systematic review meta‐analysis were performed evaluate relationship incidence in general population. Methods Cohort relevant retrieved by searching electronic databases including PubMed, Web Science, Embase. A random‐effects model was used combine data incorporating influence between‐study heterogeneity. Subgroup meta‐regression analyses investigate source Results Nine cohort 49,218 community‐derived participants included. Among them, 3177 (6.5%) had at baseline. During a mean follow‐up 10.2 years, 4044 developed The pooled results compared with euthyroidism, those higher (risk ratio: 1.38, 95% confidence interval: 1.09 1.74, p = .006; I 2 47%). according study design, age participants, methods for diagnosis dementia, or analytic did not significantly change univariate cutoff thyroid‐stimulating hormone defining negatively affected (coefficient: –1.44, .009), which completely explained heterogeneity (residual 0%). Conclusion Subjects have euthyroidism.

Language: Английский

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Modifiable dementia risk associated with smaller white matter volume and altered 1/f aperiodic brain activity: cross-sectional insights from the LEISURE study

Age and Ageing, Journal Year: 2024, Volume and Issue: 53(11)

Published: Oct. 25, 2024

The rising prevalence of dementia necessitates identifying early neurobiological markers risk. Reduced cerebral white matter volume and flattening the slope electrophysiological 1/f spectral power distribution provide brain ageing alongside cognitive decline. However, their association with modifiable risk remains to be understood.

Language: Английский

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Physiological Changes Linked with Alzheimer’s Disease and Related Dementias

Published: Jan. 1, 2024

Language: Английский

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