Qingzhuan dark tea Theabrownin alleviates hippocampal injury in HFD-induced obese mice through the MARK4/NLRP3 pathway

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e26923 - e26923

Published: Feb. 28, 2024

Feeding on a high-fat diet (HFD) results in obesity and chronic inflammation, which may have long-term effects neuroinflammation hippocampal injury. Theabrownin, biologically active compound derived from the microbial fermentation of Qingzhuan dark tea, exhibits anti-inflammatory properties lipid-lowering effects. Nevertheless, its potential neuroprotection has yet to be investigated. Consequently, this study aims investigate neuroprotective Theabrownin extracted as well therapeutic mechanisms.

Language: Английский

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Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(9), P. 1890 - 1898

Published: Dec. 14, 2023

Previous studies have demonstrated a bidirectional relationship between inflammation and depression. Activation of the nucleotide-binding oligomerization domain, leucine-rich repeat, NLR family pyrin domain-containing 3 (NLRP3) inflammasomes is closely related to pathogenesis various neurological diseases. In patients with major depressive disorder, NLRP3 inflammasome levels are significantly elevated. Understanding role that inflammasome-mediated neuroinflammation plays in depression may be beneficial for future therapeutic strategies. this review, we aimed elucidate mechanisms lead activation as well provide insight into strategies target inflammasome. Moreover, outlined inflammasome, including inflammatory pathway inhibitors, natural compounds, other compounds been shown effective treating Additionally, summarized application inhibitors clinical trials Currently, there scarcity dedicated investigating applications treatment. The modulation microglia holds promise management Further investigations necessary ascertain efficacy safety these approaches potential novel antidepressant treatments.

Language: Английский

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Nanotechnology‐Mediated Immunomodulation Strategy for Inflammation Resolution

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)

Published: July 23, 2024

Abstract Inflammation serves as a common characteristic across wide range of diseases and plays vital role in maintaining homeostasis. can lead to tissue damage the onset inflammatory diseases. Although significant progress is made anti‐inflammation recent years, current clinical approaches mainly rely on systemic administration corticosteroids antibiotics, which only provide short‐term relief. Recently, immunomodulatory have emerged promising strategies for facilitating resolution inflammation. Especially, advanced nanosystems with unique biocompatibility multifunctionality provided an ideal platform immunomodulation. In this review, pathophysiology inflammation therapeutic are summarized. It focused nanomedicines that modulate signaling pathways, cells, oxidative stress, targeting. Finally, challenges opportunities nanomaterials addressing also discussed. The nanotechnology‐mediated immunomodulation will open new treatment strategy therapy.

Language: Английский

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Targeting the NLRP3 inflammasome as a novel therapeutic target for osteoarthritis

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

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Toxicological mechanisms of carbon polymers in accelerating cognitive decline in Alzheimer’s disease

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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A new perspective on the regulation of neuroinflammation in intracerebral hemorrhage: mechanisms of NLRP3 inflammasome activation and therapeutic strategies

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 27, 2025

Intracerebral hemorrhage (ICH), a specific subtype within the spectrum of stroke disorders, is characterized by its high mortality and significant risk long-term disability. The initiation progression neuroinflammation play central critical role in pathophysiology ICH. NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, protein complex involved initiating inflammation, focus this article. Microglia astrocytes roles inflammatory damage process associated with neuroinflammation. NLRP3 inflammasome expressed both types glial cells, activation drives these cells toward pro-inflammatory phenotype, which exacerbates brain. However, regulatory relationship between two cell remains to be explored. Targeting inflammasomes microglia or may provide an effective approach mitigate following This article first provides overview composition mechanisms inflammasome. Subsequently, it summarizes recent research findings on novel signaling pathways that regulate activity. Finally, we reviewed progress inhibitors, highlighting clinical translation potential certain candidates. These inhibitors hold promise as innovative strategies for managing inflammation

Language: Английский

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Research Progress of Bile Acids in Neurodegenerative Diseases

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 1718 - 1724

Published: Jan. 1, 2025

Language: Английский

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Influence of feelings on the blood-brain barrier (BBB) and drug delivery

Progress in brain research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Abscisic Acid Rescues Behavior in Adult Female Mice in Attention Deficit Disorder with Hyperactivity Model of Dopamine Depletion by Regulating Microglia and Increasing Vesicular GABA Transporter Expression

Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 15, 2025

Language: Английский

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Repetitive prefrontal tDCS activates VTA dopaminergic neurons, resulting in attenuation of Alzheimer’s Disease-like deficits in Tg2576 mice

Alzheimer s Research & Therapy, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 29, 2025

Language: Английский

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