Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: March 7, 2025
Redox
signaling
acts
as
a
critical
mediator
in
the
dynamic
interactions
between
organisms
and
their
external
environment,
profoundly
influencing
both
onset
progression
of
various
diseases.
Under
physiological
conditions,
oxidative
free
radicals
generated
by
mitochondrial
respiratory
chain,
endoplasmic
reticulum,
NADPH
oxidases
can
be
effectively
neutralized
NRF2-mediated
antioxidant
responses.
These
responses
elevate
synthesis
superoxide
dismutase
(SOD),
catalase,
well
key
molecules
like
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
glutathione
(GSH),
thereby
maintaining
cellular
redox
homeostasis.
Disruption
this
finely
tuned
equilibrium
is
closely
linked
to
pathogenesis
wide
range
Recent
advances
have
broadened
our
understanding
molecular
mechanisms
underpinning
dysregulation,
highlighting
pivotal
roles
genomic
instability,
epigenetic
modifications,
protein
degradation,
metabolic
reprogramming.
findings
provide
foundation
for
exploring
regulation
mechanistic
basis
improving
therapeutic
strategies.
While
antioxidant-based
therapies
shown
early
promise
conditions
where
stress
plays
primary
pathological
role,
efficacy
diseases
characterized
complex,
multifactorial
etiologies
remains
controversial.
A
deeper,
context-specific
signaling,
particularly
redox-sensitive
proteins,
designing
targeted
aimed
at
re-establishing
balance.
Emerging
small
molecule
inhibitors
that
target
specific
cysteine
residues
proteins
demonstrated
promising
preclinical
outcomes,
setting
stage
forthcoming
clinical
trials.
In
review,
we
summarize
current
intricate
relationship
disease
also
discuss
how
these
insights
leveraged
optimize
strategies
practice.
Abstract
Recent
advances
in
understanding
the
modulatory
functions
of
gut
and
microbiota
on
human
diseases
facilitated
our
focused
attention
contribution
to
pathophysiological
alterations
many
extraintestinal
organs,
including
liver,
heart,
brain,
lungs,
kidneys,
bone,
skin,
reproductive,
endocrine
systems.
In
this
review,
we
applied
“gut–X
axis”
concept
describe
linkages
between
other
organs
discussed
latest
findings
related
axis,”
underlying
mechanisms
potential
clinical
intervention
strategies.
The journal of nutrition health & aging,
Journal Year:
2024,
Volume and Issue:
28(6), P. 100224 - 100224
Published: April 5, 2024
Maintaining
ideal
cardiovascular
health
(CVH)
is
believed
to
have
potential
anti-aging
benefits.
The
American
Heart
Association
(AHA)
recently
updated
the
"Life's
Essential
8
(LE8)"
metrics
measure
CVH,
but
its
connection
with
protein
klotho
still
unclear.
We
aimed
explore
relationship
between
and
serum
in
a
nationally
representative
US
middle-aged
older
population.
A
cross-sectional
study.
National
Health
Nutrition
Examination
Survey
(2007−2016).
total
of
9457
participants.
Ideal
CVH
scores
their
components
were
defined
according
guidelines
set
by
AHA.
Serum
detected
enzyme-linked
immunosorbent
assay.
Weighted
multivariable
linear
regression
restricted
cubic
spline
employed
examine
association
score
klotho.
Subgroup
analyses
conducted,
stratified
age
(40−59
60−79),
sex
(Male
Female),
race
(Mexican
American,
non-Hispanic
White,
Black,
Others)
chronic
kidney
disease
(Yes
No)
fully
adjusted
models.
participants
included
this
study,
mean
55.27
±
0.17
years.
level
population
was
849.33
5.39
pg/mL.
After
controlling
for
confounders,
LE8
showed
positive
correlation
levels
(β:
1.32;
95%
CI
0.73,
1.91),
non-linear
dose-response
observed.
Furthermore,
we
also
discovered
behaviors
factors
0.48;
0.07,
0.88
β:
1.05;
0.54,
1.56,
respectively),
particularly
stronger
In
subgroup
analysis,
observed
significant
interaction
race.
(P
<0.05).
subscale
positively
associated
populations.
Promoting
maintenance
can
contribute
delaying
aging
process.
Frontiers in Aging Neuroscience,
Journal Year:
2024,
Volume and Issue:
16
Published: Feb. 28, 2024
Sensorineural
hearing
loss
(SNHL)
is
a
category
of
that
often
leads
to
difficulty
in
understanding
speech
and
other
sounds.
Auditory
system
dysfunction,
including
deafness
auditory
trauma,
results
cognitive
deficits
via
neuroplasticity.
Cognitive
impairment
(CI)
refers
an
abnormality
the
brain’s
higher
intellectual
processes
related
learning,
memory,
thinking
judgment
can
lead
severe
learning
memory
deficits.
Studies
have
established
strong
correlation
between
SNHL
CI,
but
it
remains
unclear
how
contributes
CI.
The
purpose
this
article
describe
three
hypotheses
regarding
relationship,
mainstream
load
hypothesis,
co-morbidity
sensory
deprivation
as
well
latest
research
progress
each
hypothesis.
Frontiers in Public Health,
Journal Year:
2025,
Volume and Issue:
13
Published: April 16, 2025
Cardiometabolic
diseases
are
prevalent
among
ageing
populations
and
have
a
close
association
with
frailty.
However,
the
cumulative
impact
multiple
cardiometabolic
on
frailty
remains
underexplored.
This
study
used
data
from
four
international
cohorts
-
HRS,
CHARLS,
ELSA
SHARE
to
examine
correlation
between
(CMD).
The
index
was
for
assessing
statistical
analyses
were
performed
as
means
of
analysing
number
conditions
severity.
Linear
regression
models
employed
evaluate
associations
CMD
found
that
increased,
rose
significantly
[one
disease,
β
=
7.80
(95%
CI:
7.70
7.90)
p
<
0.05;
two
diseases,
17.92
17.76
18.08)
three
28.79
28.41
29.17)
0.05].
Stroke
most
pronounced
(β
12.34
[95%CI
12.20
12.48]
0.05)
coexistence
served
amplify
symptoms
highlights
compounded
also
emphasizes
necessity
early
intervention.
Cardiovascular Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 12, 2024
Abstract
Inflammageing,
characterized
by
persistent
chronic
inflammation
in
older
adults,
has
emerged
as
a
critical
factor
linked
to
age-related
diseases,
such
cardiovascular
diseases
(CVDs),
metabolic
disorders,
and
cognitive
decline,
which
collectively
contribute
the
leading
causes
of
death
globally.
Elevated
levels
cytokines,
chemokines,
other
inflammatory
mediators
characterize
inflammageing
serve
indicators
biological
age.
Among
inflammageing,
deterioration
immune
system,
mitochondrial
dysfunction,
dysbiosis,
accumulation
DAMPs,
together
with
genetic
or
epigenetic
factors,
not
only
CVD
but
also
conditions.
This
review
examines
consequences
particularly
its
implications
for
atherosclerosis
heart
failure
preserved
ejection
fraction
explores
potential
strategies
mitigate
it
onset
CVD.
Age-related
pathologies,
particularly
cardiovascular
disorders,
pose
a
significant
global
health
concern.
The
World
Health
Organization
(WHO)
predicts
an
increase
in
advanced
mortality
by
2030
unless
critical
interventions
are
implemented.
Atherosclerosis
remains
the
major
cause
of
various
diseases.
Hence,
this
review
focused
on
interaction
between
known
mechanisms
vascular
aging,
disease
manifestation,
and
progression
during
atherosclerosis.
In
review,
we
highlighted
five
altered
models:
genomic
instability,
neurohormonal
deregulation,
epigenetics,
protein
regulation,
gut
microbiome.
articles
were
selected
from
indexed
scientific
databases.
It
is
important
to
note
that
equally
interrelated
with
other
aging
pathways,
such
as
inflammation
senescence.
conclusion,
atherosclerosis
multifaceted
cholesterol-lowering
therapy
has
been
widely
used.
However,
more
than
one
specific
action
line
required
eradicate
or
slow
down
its
manifestation.
Equally,
establishing
balance
stressors
resulting
injuries
stress
buffering
treatment
promising
therapeutic
targets
reviewed
include
angiotensin
(1–7)/MAS
axis,
microbiome,
histone
deacetylases,
DNA
repair
systems,
noncoding
RNAs,
β3/dopamine
adrenoceptors,
senescence
checkpoints.
