The Unique Immune System of Bats: An Evolutionary Analysis and Bibliometric Study DOI Creative Commons
Rui Li,

Wenliang Zhao,

Apeng Chen

et al.

Ecology and Evolution, Journal Year: 2024, Volume and Issue: 14(11)

Published: Nov. 1, 2024

Bats exhibit a greater capacity to tolerate diverse viruses than other terrestrial mammals. To address these questions, we utilized evolutionary and bibliometric analyses explore the immunological characteristics of bats identify contemporary research hotspots in bat immunity. investigate historical interactions between viral infections, used tBLASTn software integrated endogenous retroviruses within genomes nine species seven elucidate immune bats, OrthoFinder, CAFE, Gene Ontology phylogenetic trees homologous genes, expanded/contracted gene families, associated signaling pathways 28 mammalian genomes. We also analysis "immune system bats" deepen our understanding mechanisms bats. Significant integrations Gammaretroviruses, Spumaretroviruses, Deltaretroviruses were observed Notable expansions families included Type III interferon, heat-shock protein 90 (HSP90), members tumor necrosis factor receptor superfamily (TNFRSF). These expanded are involved related "transcription replication influenza virus RNA," "COVID-19-related pathways," "positive regulation phosphorylation." contractions "type I interferon" "antibody-related families." Bibliometric further underscored several significance critical such as HSP90, TNF. The exploration revealed two predominant themes: "efficient varied antiviral responses" "dampened inflammation prevent excessive inflammatory reactions," thereby elucidating underlying adaptations Through analyses, identified genes Currently, on primarily focuses themes "inflammation suppression."

Language: Английский

Neurocognitive features of mild cognitive impairment and distress symptoms in older adults without major depression DOI Open Access
Gallayaporn Nantachai, Michaël Maes, Vinh-Long Tran-Chi

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 7, 2023

Abstract Background Two distinct symptom dimensions were identified in older adults who did not have major depressive disorder (MDD): a) a dimension associated with mild cognitive dysfunction, and b) related to distress symptoms of old age (DSOA). It is uncertain whether previous findings regarding the features amnestic impairment (aMCI) remain valid when patients MDD are excluded. Objectives To examine, participants without MDD, neurocognitive characteristics aMCI objective DSOA. Neurocognition was evaluated utilizing Cambridge Neurological Test Automated Battery (CANTAB) memory tests. Results This research demonstrated that CANTAB tests capability differentiate between controls. The One Touch Stockings Cambridge, probability solved on first choice (OTS_PSFC), Rapid Visual Information Processing, A prime, Motor Screening Task, mean latency (MOT_ML), as significant discriminatory 37.6% variance severity predicted by OTS_PSFC, RVP_A’, word list recognition scores, education. Psychosocial stressors (adverse childhood experiences, negative life events), subjective feelings impairment, RVP, false alarm, account for 40.0% DSOA score. Discussion When ruled out, linked deficits attention, executive functions, memory. statistically impact or its severity. Enhanced alarm response bias coupled heightened psychological stress (including perception decline) may contribute an increase among elderly. Keys word: depression, adverse stress, anxiety

Language: Английский

Citations

3
Research trends and hotspots in biologics for plaque psoriasis: A bibliometric study from 2004 to 2023 DOI Creative Commons
Shan Huang, Xingwu Duan, Yanping Bai

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35446 - e35446

Published: July 30, 2024

Biologics have revolutionized the management of plaque psoriasis and are flourishing. We aimed to construct a knowledge structure in this field through bibliometrics, analyze research trends cutting-edge hotspots inspire future directions, provide valuable references for clinical decisions.

Language: Английский

Citations

0
Research Trends and Hot Spots in Telemedicine for the Elderly: A Scientometric Analysis DOI Open Access

Huiqian He,

Salwa Hanim Abdul‐Rashid, Raja Ariffin Raja Ghazilla

et al.

Healthcare, Journal Year: 2024, Volume and Issue: 12(18), P. 1853 - 1853

Published: Sept. 14, 2024

Background: As the elderly population rapidly grows, age-related health issues are increasing. Telemedicine helps older adults adapt by providing efficient and accessible management medical services. Objectives: This study employs bibliometric analysis to examine research focus areas, emerging trends, collaboration networks in telemedicine for over past three decades. Methods: The Web of Science Core Collection served as primary data source publications on since database’s inception through June 2024. Using CiteSpace.6.2.R4 software, keyword network visualizations were generated, including clusters, co-authors, co-citations. Results: analyzed 586 papers from 252 countries or regions, which published across 246 journals written 2750 authors. Conclusions: revealed directions encompassing 42 clusters: (1) literacy technology adaptation; (2) management; (3) social interaction economic impact. Research hotspots include fitness, mobile health, acceptance, telemedicine, care, literacy. Despite potential benefit challenges persist areas such usability, effectiveness, service quality, privacy concerns. review provides a comprehensive overview current highlights trends field.

Language: Английский

Citations

0
The Unique Immune System of Bats: An Evolutionary Analysis and Bibliometric Study DOI Creative Commons
Rui Li,

Wenliang Zhao,

Apeng Chen

et al.

Ecology and Evolution, Journal Year: 2024, Volume and Issue: 14(11)

Published: Nov. 1, 2024

Bats exhibit a greater capacity to tolerate diverse viruses than other terrestrial mammals. To address these questions, we utilized evolutionary and bibliometric analyses explore the immunological characteristics of bats identify contemporary research hotspots in bat immunity. investigate historical interactions between viral infections, used tBLASTn software integrated endogenous retroviruses within genomes nine species seven elucidate immune bats, OrthoFinder, CAFE, Gene Ontology phylogenetic trees homologous genes, expanded/contracted gene families, associated signaling pathways 28 mammalian genomes. We also analysis "immune system bats" deepen our understanding mechanisms bats. Significant integrations Gammaretroviruses, Spumaretroviruses, Deltaretroviruses were observed Notable expansions families included Type III interferon, heat-shock protein 90 (HSP90), members tumor necrosis factor receptor superfamily (TNFRSF). These expanded are involved related "transcription replication influenza virus RNA," "COVID-19-related pathways," "positive regulation phosphorylation." contractions "type I interferon" "antibody-related families." Bibliometric further underscored several significance critical such as HSP90, TNF. The exploration revealed two predominant themes: "efficient varied antiviral responses" "dampened inflammation prevent excessive inflammatory reactions," thereby elucidating underlying adaptations Through analyses, identified genes Currently, on primarily focuses themes "inflammation suppression."

Language: Английский

Citations

0