Possible sarcopenia, Sarcopenic obesity phenotypes and their association with diabetes: Evidence from LASI wave-1 (2017-18)

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2025, Volume and Issue: 19(2), P. 103185 - 103185

Published: Jan. 11, 2025

Language: Английский

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Relationship of Low Vitamin B6 Status with Sarcopenia, Frailty, and Mortality: A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(1), P. 177 - 177

Published: Jan. 4, 2024

Marginal vitamin B6 (B6) deficiency is a widespread global concern. Inadequate levels have been linked to an increased risk of age-related chronic diseases such as cardiovascular and cancers. In recent years, the growing concern over sarcopenia (the loss muscle mass strength) frailty (a decline in physiological resilience vulnerability associated with aging) particularly relevant due emergence super-aged societies developed countries. Notably, among thirty-one studies included this review, twenty-five showed significant association status sarcopenia, frailty, all-cause mortality adults (p < 0.05), while six no association. Emerging suggested novel mechanisms underlying These involve P2X7 receptor-mediated NLRP3 inflammasome signaling, AMPK PD-L1 satellite cell-mediated myogenesis. Furthermore, modulation PLP-dependent enzymes impaired metabolic processes, affecting energy utilization, imidazole peptide production, hydrogen sulfide well kynurenine pathway, all which play vital roles skeletal health pathophysiology. This narrative review provides up-to-date assessment our current understanding potential role nutritional combating mortality.

Language: Английский

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Relationship Between Body Mass Index and Low Skeletal Muscle Mass in Adults Based on NHANES 2011–2018

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 21, 2025

Sarcopenia, a syndrome characterized by declining muscle mass and function, is associated with various adverse health outcomes. While body index (BMI) fundamental indicator, its relationship sarcopenia complex remains inadequately explored. Low BMI has been linked to loss, but the role of other demographic clinical factors in this unclear. This cross-sectional study analyzed data from NHANES 2011–2018 cohort, including 7,455 adults aged ≥ 20 years. was diagnosed based on appendicular skeletal using DXA criteria. categorized into quartiles for analysis. Weighted multivariable logistic regression assessed associations between low mass, adjusting confounders such as age, gender, ethnicity, income-to-poverty ratio, chronic diseases (e.g., diabetes hypertension). Variance inflation (VIF) confirmed absence multicollinearity. Lower significantly higher odds (adjusted OR: 0.508, 95% CI: 0.483–0.533, p < 0.001), while exhibited protective effect. Age (OR: 1.035, 1.025–1.045, 0.001) female gender 1.570, 1.267–1.949, were independent risk factors. Racial disparities noted, non-Hispanic Black individuals at lower compared Whites 0.242, 0.152–0.384, 0.001). Other significant included alcohol consumption, education smoking status not associated. inversely prevalence, posing odds. The findings underscore importance monitoring addressing multifactorial profiles management prevention.

Language: Английский

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Sarcopenic obesity and the risk of atrial fibrillation in non-diabetic older adults: a prospective cohort study

Clinical Nutrition, Journal Year: 2025, Volume and Issue: 47, P. 282 - 290

Published: March 4, 2025

Language: Английский

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Reverse epidemiology of obesity paradox: Fact or fiction?

Physiological Reports, Journal Year: 2024, Volume and Issue: 12(21)

Published: Oct. 29, 2024

Abstract Obesity paradox refers to the clinical observation that when acute cardiovascular decompensation occurs, patients with obesity may have a survival benefit. This apparently runs counter epidemiology of obesity, which increase risk for non‐communicable diseases (NCDs). The scientific community is split on paradox, some supporting it, while others call it BMI paradox. review: (a) defines and its proposed role in overall mortality NCDs; (b) delineates evidence against paradox; (c) presents importance using different indices body mass assess (d) examines metabolically healthy emerging cardio‐respiratory fitness (CRF) as an independent predictor CVD all‐cause with/without obesity. Evidence suggests development insulin resistance are influenced by genetic (or ethnic) make up dietary habits (culture) individuals. Hence, this review lean diabetes, has higher total non‐CVD compared diabetics possibility maternal factors programming cardiometabolic during fetal development, lead paradigm shift our understanding

Language: Английский

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Systemic Inflammation and Disruption of the Local Microenvironment Compromise Muscle Regeneration: A Critical Pathogenesis of Autoimmune-associated Sarcopenia (Preprint)

Interactive Journal of Medical Research, Journal Year: 2025, Volume and Issue: 14, P. e64456 - e64456

Published: Feb. 25, 2025

Abstract Sarcopenia is defined by age-related reductions in muscle mass, strength, and physiological function, it especially prevalent among individuals with autoimmune diseases. Autoimmune disorders, characterized immune dysregulation, cause systemic inflammation damage to multiple tissues through unregulated activity. Research indicates that diseases negatively impact skeletal functions may worsen the progression of sarcopenia. This viewpoint comprehensively discusses pathogenesis potential mechanism sarcopenia 3 diseases: inflammatory bowel disease, rheumatoid arthritis, type 1 diabetes mellitus. Mechanistically, chronic microenvironment alterations induce compartment-specific redistribution leukocyte subsets cytokine networks. These perturbations disrupt critical signaling pathways governing protein synthesis, satellite cell activation, mitochondrial bioenergetics, leading impaired regeneration accelerated progression. By delineating shared distinct pathomechanisms across these models, this analysis reframes our understanding immune-mediated wasting. Beyond mechanistic insights, establishes a translational framework for targeted therapies highlights emerging research directions bridging immunology musculoskeletal decline.

Language: Английский

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Adipositas im Alter – Auswirkungen auf Kraft und -Funktion der Skelettmuskulatur

Adipositas - Ursachen Folgeerkrankungen Therapie, Journal Year: 2025, Volume and Issue: 19(01), P. 8 - 17

Published: Feb. 28, 2025

Zusammenfassung Die zentrale Bedeutung der Muskelmasse, -kraft und -funktion im Alter ist eindeutig wissenschaftlich belegt. Frage, wie sich eine Adipositas auf die Kraft Funktion Skelettmuskulatur auswirkt, wurde jedoch lange Zeit kaum systematisch untersucht. Diese Arbeit gibt Übersicht über Kohortenstudien zum Zusammenhang von mit Muskelkraft diskutiert zugrundeliegende Ursachen Fettinfiltration, subklinische Inflammation mitochondriale Dysfunktion. zeigen, dass trotz Zunahme des Muskelvolumens negativ beeinflusst, was zu Aktivitätseinschränkungen einem höheren Risiko für Invalidität führen kann. Neue Daten weisen darauf hin, Fettinfiltration Skelettmuskel geringerer Muskelqualität Leistungsfähigkeit assoziiert ist. Weitere Mechanismen Dysfunktion tragen ebenfalls zur Verschlechterung bei.

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Probable and confirmed sarcopenia are still better predictors of disability than sarcopenic obesity following ESPEN/EASO consensus steps

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 15, 2025

Abstract Background Studies comparing different operational definitions of sarcopenia (S) and sarcopenic obesity (SO) defined according to the ‘’European Society for Clinical Nutrition Metabolism European Association Study Obesity’’ (ESPEN/EASO) criteria with functionality are scarce. Our aim is investigate whether SO or S skeletal muscle mass (SMM) adjustments better associated functional disability. Methods This retrospective study was carried out in older individuals ≥ 65 years age a geriatric outpatient clinic. Probable confirmed were evaluated revised Working Group on Sarcopenia Older People (EWGSOP2) criteria, ESPEN/EASO consensus steps. For SMM component both SO, (weight, body index, height square (W, BMI, H 2 respectively)) used. Functional disability examined activities daily living (ADL), instrumental ADL (IADL). Receiver operating characteristic (ROC) curves drawn area under ROC curve (AUC) calculated find which definition best predicts Results Data from 1477 adults screened. 408 participants (median age; 73 (65–101), 65% female) included. Prevelance 6.9%. sarcopenia, BMI-adjusted W-adjusted significantly impaired IADL ( p < 0.001), showed fair accuracy predicting Sarcopenic did not show significant associations didn’t predict Only by BMI predicted poor accuracy. Among probable had highest sensitivity (83.6%) negative predictive value (NPV) (94.2%) Conclusion We found that (with NPV) (BMI-adjusted higher NPV than W-adjusted) most relevant disability, but their diagnostic limited. Confirmed Other definitions, including our study. Future studies need refine its distinct impact impairment compared alone.

Language: Английский

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Association of sarcopenia with all-cause and cause-specific mortality in cancer patients: development and validation of a 3-year and 5-year survival prediction model

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 22, 2025

Sarcopenia is a clinicopathological condition characterized by decrease in muscle strength and mass, playing crucial role the prognosis of cancer. Therefore, this study aims to investigate association between sarcopenia both all-cause mortality cancer-specific among cancer patients. Furthermore, we plan develop risk prediction models using machine learning algorithms predict 3-year 5-year survival rates This included 1095 patients from National Health Nutrition Examination Survey (NHANES) cohorts spanning 1999-2006 2011-2014. Initially, used Least Absolute Shrinkage Selection Operator (LASSO)-Cox regression for feature selection. Subsequently, employed multivariable Cox We developed five algorithms, including Support Vector Machine (SVM), Logistic Regression (LR), Random Forest (RF), LightGBM, XGBoost, perform stratification. The COX model showed significantly increases (HR = 1.33, 95%CI:1.05, 1.70, P 0.0194) 1.67, 95%CI:1.09, 2.55, 0.0176) Among developed, LightGBM demonstrated strong performance tasks, making it optimal Decision curve analysis Kaplan-Meier curves further confirmed our model's ability identify high-risk individuals effectively. that effectively identifies individuals, thereby providing foundation personalized assessment.

Language: Английский

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Association between sarcopenic obesity and risk of frailty in older adults: a systematic review and meta-analysis

Age and Ageing, Journal Year: 2024, Volume and Issue: 54(1)

Published: Dec. 22, 2024

Abstract Background Age-related changes in body composition such as muscle loss can lead to sarcopenia, which is closely associated with frailty. However, the effect of fat accumulation on frailty old age remains unclear. In particular, association between combination these two conditions, known sarcopenic obesity, and older adults Objective To synthesise obesity risk investigate role age. Methods Six databases were searched from inception 29 September 2024. Two reviewers independently extracted data assessed bias for included observational studies using adapted Newcastle–Ottawa scale. The control groups consisted robust, obese individuals. Meta-analyses performed examine due amongst adults. Results Sixteen eligible meta-analyses 1098 records. Compared robust individuals, more vulnerable [odds ratio (OR), 3.76; 95% confidence interval (CI), 2.62 5.39; I2 = 79.3%; P &lt; .0001]. Obesity was not (OR, 1.23; CI, 0.99 1.53; 0.0%; .501) Conclusions Sarcopenic a high Sarcopenia may have synergistic effects

Language: Английский

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