Biomolecules,
Journal Year:
2024,
Volume and Issue:
15(1), P. 18 - 18
Published: Dec. 26, 2024
The
biological
process
of
aging
is
influenced
by
a
complex
interplay
genetic,
environmental,
and
epigenetic
factors.
Recent
advancements
in
the
fields
epigenetics
senolytics
offer
promising
avenues
for
understanding
addressing
age-related
diseases.
Epigenetics
refers
to
heritable
changes
gene
expression
without
altering
DNA
sequence,
with
mechanisms
like
methylation,
histone
modification,
non-coding
RNA
regulation
playing
critical
roles
aging.
Senolytics,
class
drugs
targeting
eliminating
senescent
cells,
address
accumulation
dysfunctional
cells
that
contribute
tissue
degradation
chronic
inflammation
through
senescence-associated
secretory
phenotype.
This
scoping
review
examines
intersection
senolytic
therapies
aging,
focusing
on
their
combined
potential
therapeutic
interventions.
Senescent
display
distinct
signatures,
such
as
hypermethylation
modifications,
which
can
be
targeted
enhance
efficacy.
Epigenetic
reprogramming
strategies,
induced
pluripotent
stem
may
further
complement
rejuvenating
aged
cells.
Integrating
modulation
therapy
offers
dual
approach
improving
healthspan
mitigating
pathologies.
narrative
underscores
need
continued
research
into
molecular
underlying
these
interactions
suggests
future
directions
development,
including
clinical
trials,
biomarker
discovery,
combination
synergistically
target
processes.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 3881 - 3881
Published: March 30, 2024
Epigenetic
changes
are
in
gene
expression
that
do
not
involve
alterations
to
the
DNA
sequence.
These
lead
establishing
a
so-called
epigenetic
code
dictates
which
and
when
genes
activated,
thus
orchestrating
regulation
playing
central
role
development,
health,
disease.
The
brain,
being
mostly
formed
by
cells
undergo
renewal
process
throughout
life,
is
highly
prone
risk
of
leading
neuronal
death
neurodegenerative
disorders,
mainly
at
late
age.
Here,
we
review
main
modifications
have
been
described
with
particular
attention
on
those
related
onset
developmental
anomalies
or
conditions
and/or
occurring
old
methylation
several
types
histone
(acetylation,
methylation,
phosphorylation,
ubiquitination,
sumoylation,
lactylation,
crotonylation)
major
players
these
processes.
They
directly
indirectly
involved
neurodegeneration
Alzheimer's
Parkinson's
Therefore,
this
briefly
describes
roles
mechanisms
brain
maturation,
aging
some
most
important
factors
dynamically
regulating
contributing
changes,
such
as
oxidative
stress,
inflammation,
mitochondrial
dysfunction.
Aging and Disease,
Journal Year:
2025,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2025
Aging
is
marked
by
a
progressive
decrease
in
physiological
function
and
reserve
capacity,
which
results
increased
susceptibility
to
diseases.
Understanding
the
mechanisms
of
driving
aging
crucial
for
extending
health
span
promoting
human
longevity.
Hypoxia,
reduced
oxygen
availability,
has
emerged
as
promising
area
study
within
research.
This
review
explores
recent
findings
on
potential
restriction
promote
healthy
extend
lifespan.
While
role
hypoxia-inducible
factor
1
(HIF-1)
cellular
responses
hypoxia
well-established,
its
impact
lifespan
remains
complex
context-dependent.
Investigations
invertebrate
models
suggest
HIF-1
longevity,
while
evidence
mammalian
limited.
Hypoxia
extends
independent
dietary
(DR),
known
intervention
underlying
However,
both
DR
converge
common
downstream
effectors,
such
forkhead
box
O
(FOXO)
flavin-containing
monooxygenase
(FMOs)
modulate
Further
work
required
elucidate
molecular
hypoxia-induced
longevity
optimize
clinical
applications.
crosstalk
between
other
longevity-associated
pathways
developing
interventions
enhance
healthspan.
Future
studies
may
uncover
novel
therapeutic
strategies
populations.
GeroScience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
Abstract
Aging
is
driven
by
fundamental
mechanisms
like
oxidative
stress,
telomere
shortening
and
changes
in
DNA
methylation,
which
together
prepare
the
ground
for
age-related
diseases.
Botanical
extracts,
rich
bioactive
phytoconstituents,
represent
a
promising
resource
developing
therapies
that
target
these
to
promote
healthy
aging.
This
study
explores
geroprotective
potential
of
Monarda
didyma
L.
extract.
In
vitro
analyses
revealed
extract’s
strong
antioxidant
activity,
ability
reduce
shortening,
capacity
protect
against
damage,
thereby
decreasing
cellular
senescence
improving
endothelial
function.
The
randomized,
double-blind
clinical
trial
demonstrated
daily
oral
supplementation
with
extract
significantly
improved
leukocyte
length
(LTL)
stabilized
methylation
age
(DNAmAge)
intervention
group,
while
placebo
group
experienced
accelerated
epigenetic
aging
hypermethylation
critical
genes
(ELOVL2
FHL2).
also
reported
enhanced
quality
life,
particularly
physical
domain,
along
movement
sleep
indices
detected
questionnaire
wearable
sensors.
These
compelling
findings
position
as
powerful
candidate
future
therapies,
impact
Bioengineering,
Journal Year:
2025,
Volume and Issue:
12(4), P. 341 - 341
Published: March 26, 2025
Cancer
treatment
has
historically
depended
on
conventional
methods
like
chemotherapy,
radiation,
and
surgery;
however,
these
strategies
frequently
present
considerable
limitations,
including
toxicity,
resistance,
negative
impacts
healthy
tissues.
In
addressing
challenges,
drug-free
cancer
therapies
have
developed
as
viable
alternatives,
utilizing
advanced
physical
biological
to
specifically
target
tumor
cells
while
reducing
damage
normal
This
review
examines
several
strategies,
such
high-intensity
focused
energy
beams,
nanosecond
pulsed
electric
fields,
photothermal
therapy
well
the
use
of
inorganic
nanoparticles
promote
selective
apoptosis.
We
also
investigate
significance
targeting
microenvironment,
precision
medicine,
immunotherapy
in
progression
personalized
therapies.
Although
approaches
demonstrate
significant
promise,
challenges
scalability,
safety,
regulatory
obstacles
must
be
resolved
for
clinical
application.
paper
presents
an
overview
current
research
therapies,
emphasizing
recent
advancements,
underlying
scientific
principles,
steps
required
implementation.
Frontiers in Aging,
Journal Year:
2025,
Volume and Issue:
6
Published: April 16, 2025
Introduction
Immunosenescence
is
a
dynamic
process,
where
both
genetic
and
environmental
factors
account
for
the
substantial
inter-individual
variability.
This
paper
integrates
all
data
on
immunosenescence
markers
generated
in
our
laboratory
describes
differences
and/or
similarities
between
individuals
based
their
biological
conditions
(immunosenescence
markers)
associations
with
chronological
age
health
status.
Materials
Methods
The
dataset
consisted
of
immunological
from
healthy
donors,
centenarians,
patients
diagnosed
chronic
kidney
disease,
COVID-19
non-small
cell
lung
cancer
(NSCLC),
treatment-naïve
or
treated
platinum-based
chemotherapy.
To
determine
whether
there
are
groups
immunologically
different
despite
clinical
condition,
cluster
analysis
was
performed.
Canonical
discriminant
performed
to
which
variables
characterize
each
cluster.
Results
There
expression
subjects
pathological
conditions,
regardless
age.
Meanwhile,
distribution
clusters
indicates
presence
two
separate
participants,
one
them
characterized
by
high
frequency
naïve
lymphocytes,
other
terminally
differentiated
lymphocyte
subsets.
Advanced
NSCLC
were
same
as
group
subjects.
Additionally,
centenarians
belong
than
subjects,
suggesting
they
might
have
unique
immune
signature.
Conclusion
appears
be
more
appropriate
univariate
single
disease
research.
present
work
reveals
relevant
physiological
contexts
need
deeper
studies
system.
