Anti-Aging Effects of Flavonoids from Plant Extracts

Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2441 - 2441

Published: Aug. 2, 2024

Aging is a natural and irreversible process, affecting living organisms by negatively impacting the tissues' cells' morphology functionality consequently being responsible for aging-related diseases. Taking into account actual preoccupations of both consumers researchers, healthy anti-aging alternatives are intensively studied in order to address such concerns. Due their functional features, plant flavonoids can be considered valuable nutraceuticals. This paper highlights possibilities use extracted from various plants potential on skin, brain, heart. Moreover, anticarcinogenic, anti-inflammatory, anti-diabetic properties summarized, along with senescence-associated mechanisms. Both nutraceutical cosmeceutical fields continuously developing originating promising candidates obtain products. Thus, bioactive compounds' extraction subsequent involvement innovative product manufacturing must carefully performed while aware intrinsic extrinsic factors that may affect phytochemicals' structures, bioavailability, health effects.

Language: Английский

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Nutrition: A non‐negligible factor in the pathogenesis and treatment of Alzheimer's disease

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract Alzheimer's disease (AD) is a degenerative characterized by progressive cognitive dysfunction. The strong link between nutrition and the occurrence progression of AD pathology has been well documented. Poor nutritional status accelerates progress potentially aggravating amyloid beta (Aβ) tau deposition, exacerbating oxidative stress response, modulating microbiota–gut–brain axis, disrupting blood–brain barrier function. advanced stage tends to lead malnutrition due impairments, sensory dysfunctions, brain atrophy, behavioral psychological symptoms dementia (BPSD). This, in turn, produces vicious cycle AD. This review discusses how factors deteriorate each other from early terminal stages AD, focusing on potential different levels factors, ranging micronutrients diet patterns. provides novel insights into reducing risk delaying its progression, improving prognosis. Highlights Two‐fifths cases worldwide have attributed modifiable factors. Up ≈26% community‐dwelling patients with are malnourished, compared 7%∼76% institutionalized patients. Undernutrition effects onset, prognosis through multiple mechanisms. Various supports were confirmed be protective for via specific

Language: Английский

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A systematic review of lifestyle-based interventions for managing Alzheimer's disease: Insights from randomized controlled trials

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Background Alzheimer's disease (AD) presents a significant challenge in healthcare, prompting exploration into non-pharmacological interventions to complement traditional treatments. Objective This systematic review explores the efficacy of lifestyle-based managing AD. Methods A comprehensive literature search was conducted PubMed, Web Science, and Scopus between 2018 2023, selecting randomized controlled trials examining factors such as exercise, diet, stress, cognitive training AD patients. Results The revealed physical exercise predominant intervention, accompanied by dietary modifications, training, therapies mindfulness music. While demonstrated improvements quality life, its benefits were limited. Modified diets, Atkins ketogenic, displayed inconsistent effects on function but influenced other health-related parameters. Additionally, probiotic therapy novel technologies explored. Conclusions Despite some showing promise enhancing slowing progression, uncertainties remain regarding dose-response relationship, underlying mechanisms, potential synergistic effects. Moreover, consideration genetic sex-based disparities is warranted. synthesis underscores need for further research elucidate nuances effectively. PROSPERO registration number CRD42023432823

Language: Английский

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Malnutrition exacerbating neuropsychiatric symptoms on the Alzheimer's continuum is relevant to the cAMP signaling pathway: Human and mouse studies

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract INTRODUCTION Malnutrition correlates with neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD); however, the potential mechanism underlying this association remains unclear. METHODS Baseline and longitudinal associations of nutritional status NPSs were analyzed 374 patients on AD continuum 61 healthy controls. Serum biomarkers, behavioral tests, cerebral neurotransmitters, differentially gene expression evaluated standard malnourished diet–fed transgenic APPswe/PSEN1dE9 (APP/PS1) mice. RESULTS Poor increased blood flow midbrain striatum associated severe general subtypes, especially depression, anxiety, apathy. APP/PS1 mice fed a diet showed poor status, depression‐ anxiety‐like behaviors, altered neurotransmitter levels, downregulated c‐Fos striatum; these suppressed cyclic adenosine monophosphate (cAMP) signaling pathway. DISCUSSION exacerbating is relevant to cAMP pathway striatum, suggesting for targeted interventions mitigate continuum. Highlights linked specific symptom (NPS) deterioration. affects NPSs, usually involving striatum. Malnourished induces behaviors exacerbates

Language: Английский

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Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer’s Disease

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 922 - 922

Published: March 6, 2025

Background: Alzheimer's disease (AD) represents one of the major challenges modern medicine, with a growing impact on public health and healthcare systems. In recent years, dietary supplements use has been subject increasing interest as complementary strategy for prevention treatment disease. Materials Methods: A Review reviews was conducted following PRISMA guidelines REAPPRAISED checklist to evaluate efficacy safety supplement in AD. The search, performed across scientific databases, identified 54 relevant articles, including 53 mini-review, after applying specific inclusion criteria removing duplicates. Results: body evidence suggests that some may help reduce cognitive decline, inflammation, target mechanisms behind However, many these are still under investigation, mixed results highlighting need high-quality research. key challenge is lack data optimal dosages, administration duration, long-term safety, which limits clinical guidelines. Some studies have reported positive effects from regimens, such curcumin (800 mg/day), omega-3 fatty acids (2 g/day), resveratrol (600 mg/day). Other supplements, like phosphatidylserine (300 multinutrient formulations, probiotics, vitamin E (2000 IU/day), melatonin (3-10 also show benefits, though study variability makes conclusions uncertain. Conclusions: While certain potential mitigating decline AD, inconsistent findings gaps dosage highlight rigorous, large-scale trials. Future research should focus personalized, multimodal strategies integrating targeted supplementation, patterns, microbiota-gut-brain interactions enhanced neuroprotection.

Language: Английский

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Identification of Key Fatty Acid Metabolism-Related Genes in Alzheimer’s Disease

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Language: Английский

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Estrogen signalling and Alzheimer's disease: Decoding molecular mechanisms for therapeutic breakthrough

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(1), P. 3466 - 3490

Published: May 10, 2024

Abstract In females, Alzheimer's disease (AD) incidences increases as compared to males due estrogen deficiency after menopause. Estrogen therapy is the mainstay for menopause and associated complications. Estrogen, a hormone with multifaceted physiological functions, has been implicated in AD pathophysiology. plays crucial role amyloid precursor protein (APP) processing overall neuronal health by regulating various factors such brain‐derived neurotrophic factor (BDNF), intracellular calcium signalling, death domain‐associated (Daxx) translocation, glutamatergic excitotoxicity, Voltage‐Dependent Anion Channel, Insulin‐Like Growth Factor 1 Receptor, estrogen‐metabolising enzymes apolipoprotein E (ApoE) polymorphisms. All these impact physiology of postmenopausal women. replacement therapies play an important treatment strategy prevent However, use may lead increased risks breast cancer, venous thromboembolism cardiovascular disease. Various therapeutic approaches have used mitigate effects on AD. These include therapy, Selective Receptor Modulators (SERMs), Beta (ERβ)‐Selective Agonists, Transdermal Delivery, Localised Combination Therapies, Metabolism Modulation Alternative Estrogenic Compounds like genistein from soy, notable phytoestrogen plant sources. mechanism via which modulate women not explained earlier thoroughly. Present review will enlighten all molecular mechanisms Along‐with this, association between estrogen, ApoE polymorphisms also be discussed

Language: Английский

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Extracellular vesicles from hiPSC-derived NSCs protect human neurons against Aβ-42 oligomers induced neurodegeneration, mitochondrial dysfunction and tau phosphorylation

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 18, 2025

Language: Английский

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Food in Brain Health

Neurology, Journal Year: 2024, Volume and Issue: 102(11)

Published: May 22, 2024

Language: Английский

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Yeast β-glucan alleviates high-fat diet-induced Alzheimer's disease-like pathologies in rats via the gut-brain axis

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134939 - 134939

Published: Aug. 22, 2024

Language: Английский

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