Russian Journal of Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 50(6), P. 2209 - 2218
Published: Dec. 1, 2024
Language: Английский
Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 536 - 536
Published: Jan. 9, 2025
Hyaluronan (HA) is a ubiquitous macromolecule in the human body with remarkable structure and function. HA presents key role several biological processes mammals. The synthesis/catabolism of critical pathologies has been used as marker for prognosis cancers. Among its physiological roles, wound healing applications. This review reports many latest developments hyaluronan derivatives research, preclinical, published clinical trials healing. An adequate physico-chemical characterization identification selected properties prepared material are mandatory. Moreover, cytotoxicity evaluation effects vitro using standardized protocols required preclinical. Finally, to choose vivo models testing efficacy requested. Unfortunately, still not well understood. Therefore, an overview HA-based products provided discussed. Several ways chemical modification were evaluated. this focuses on containing HA, novel developments, gaps, limitations current state art.
Language: Английский
Citations
1
Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
1
American Journal Of Pathology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Molecular Brain, Journal Year: 2025, Volume and Issue: 18(1)
Published: April 18, 2025
Abstract Pericytes in the central nervous system are essential for maintaining blood-brain barrier function, regulating blood flow, modulating immune responses, and interacting closely with surrounding cells of neurovascular unit to support brain homeostasis. Increasing evidence has highlighted their involvement age-related neuroinflammation, where dysfunction may contribute sustained inflammatory states associated neurodegenerative disorders. Here, we compared responses lipopolysaccharide (LPS) primary cerebral pericytes from neonatal adult mice humans. Our findings indicate that mouse display heightened activation, elevated levels ICAM-1 several cytokines, reflecting a more reactive phenotype. In contrast, exhibited significantly reduced cytokine release profile, suggesting lower responsiveness. Notably, while secretion patterns human pericytes, part, mirrored those nitric oxide production, which was observed absent cells. These results underscore species- age-dependent variations cellular behavior, emphasizing importance utilizing cell systems when conducting research on neuroinflammation. Understanding these distinctions is vital designing accurate studies developing targeted therapies neuroinflammatory conditions.
Language: Английский
Citations
0
Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1716 - 1716
Published: Aug. 1, 2024
The term 'inflammaging' has been coined to describe the chronic state of inflammation derived from ongoing cycles tissue damage and subsequent immune responses. This inflammatory status contributes decline organs physiological functions, accelerates aging process, increases risk age-related illnesses death. During aging, gut microbiota (GM) undergoes significant changes, including a decreased diversity species, in beneficial bacteria, rise proinflammatory ones, resulting persistent low-grade inflammation. Moreover, environmental factors, such as diet medications, contribute changes GM function, preventing or promoting inflammaging. narrative review aims clarify underlying mechanisms inflammaging specifically investigate influence several factors on these mechanisms, while also exploring potential differences related sex. lifestyle pharmacological interventions will be suggested promote healthy aging.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 10926 - 10926
Published: Oct. 11, 2024
Circadian rhythms, the internal timekeeping systems governing physiological processes, significantly influence skin health, particularly in response to ultraviolet radiation (UVR). Disruptions circadian rhythms can exacerbate UVR-induced damage and increase risk of aging cancer. This review explores how affect various aspects physiology pathology, with a special focus on DNA repair. regulation ensures optimal repair following damage, reducing mutation accumulation, enhancing genomic stability. The control over cell proliferation apoptosis further contributes regeneration UVR. Oxidative stress management is another critical area where exert influence. Key genes like brain muscle ARNT-like 1 (BMAL1) locomotor output cycles kaput (CLOCK) modulate activity antioxidant enzymes signaling pathways protect cells from oxidative stress. also inflammatory immune responses by modulating Langerhans other skin. In summary, form complex defense network that manages through precise repair, proliferation, apoptosis, response, stress, hormonal signaling. Understanding these mechanisms provides insights into developing targeted protection improving cancer prevention.
Language: Английский
Citations
1
Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1094 - 1094
Published: Sept. 9, 2024
Quercus infectoria Olivier (Fagaceae) nutgall, a traditional Asian medicine, is renowned for its efficacy in treating wounds and skin disorders. Although the gall extract has shown promising results accelerating wound healing diabetic animal models, mechanisms, particularly effects on redox balance, remain poorly understood. This study aims to investigate mechanisms of Q. ethanolic (QIG) fibroblasts, with specific emphasis modulation oxidative stress. Hydrogen peroxide (H2O2)-treated L929 cells were used as an vitro model oxidation-damaged fibroblasts. QIG exhibited potent antioxidant activity 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), ferric reducing power (FRAP) assay values 305.43 ± 7.48, 508.94 15.12, 442.08 9.41 µM Trolox equivalents (TE)/µg, respectively. Elevated H2O2 levels significantly reduced cell viability, 50% lethal concentration 1.03 mM. mitigated H2O2-induced cytotoxicity dose-dependent manner, showing protective pre-, post-, co-treatment scenarios. intracellular reactive oxygen species production inflammation-related gene expression (p < 0.05). Additionally, at 25 µg/mL, remarkably improved closure H2O2-treated by approximately 9.4 times compared treatment alone These findings suggest potential therapeutic applications healing, mediated through regulation stress inflammatory response.
Language: Английский
Citations
0
Russian Journal of Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 50(6), P. 2209 - 2218
Published: Dec. 1, 2024
Language: Английский
Citations
0