Dual role of extracellular vesicles in neurodegenerative diseases DOI
Arianna Scuteri, E Donzelli

World Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 16(12), P. 1002 - 1011

Published: Dec. 12, 2024

Extracellular vesicles (EVs) are cell-to-cell interaction tools that attracting increasing interest in the literature two opposing areas. In addition to their role physiological development, there is growing evidence of involvement healing and protective processes. However, EVs also mediate pathological conditions, particularly contributing progression several chronic diseases, such as neurodegenerative diseases. On other hand, form core a new therapeutic strategy for neuroprotection, which based on administration derived from wide range donor cells. particular, possibility obtaining numerous stem cells different origins, feasible aims, now under investigation. this review, we focused could have propagative detrimental effect or be exploited deliver factors. This review explores hypotheses concerning dual EVs, with aim shedding light following question: Can used fight vesicle-propagated diseases?

Language: Английский

Therapeutic role of hucMSC-sEV-enriched miR-13896 in cisplatin-induced acute kidney injury through M2 macrophage polarization DOI Creative Commons
Can Jin, Peipei Wu, Wei Wu

et al.

Cell Biology and Toxicology, Journal Year: 2025, Volume and Issue: 41(1)

Published: Feb. 24, 2025

Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles (hucMSC-sEV) have recently garnered attention as a potential therapeutic approach for kidney diseases with anti-inflammatory effects. Infiltrated macrophages play an important role in facilitating tissue regeneration. However, the intricate regulatory effects of hucMSC-sEV on during cisplatin-induced acute injury (AKI) remain unknown. In this study, we uncovered that exhibited potent anti-inflammation and effectively inhibited polarization M1 phenotype macrophages. Mechanically, miRNA sequencing analysis qRT-PCR indicated novel miRNA, named miR-13896, was enriched hucMSC-sEV. When transfected miR-13896 mimic, displayed M2 elevated levels Arg1 IL-10, while inhibitor promoted phenotype. Furthermore, firstly established repressed Tradd expression by targeting its 3' untranslated region subsequently NF-κB signaling pathway Additionally, to improve effects, were engineered through electroporation, which resulted promoting macrophages, inhibiting inflammatory factors, enhancing repair. Conclusively, our findings provide insights into mechanisms underlying AKI, also highlighting electroporation promising strategy treating AKI.

Language: Английский

Citations

3
Stem cells in ageing and longevity: a new section in Biogerontology DOI Creative Commons
Vadim E. Fraifeld, Suresh I. S. Rattan

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: March 12, 2025

Language: Английский

Citations

0
The Interplay between Cellular Senescence and Side Population Stem Cells DOI Open Access
Vadim E. Fraifeld,

Maria Tombak,

Anna Knyazer

et al.

Published: March 20, 2025

Language: Английский

Citations

0
Mesenchymal stem cells and their derivatives as potential longevity-promoting tools DOI Creative Commons

Ekaterina Rudnitsky,

Alex Braiman,

Marina Wolfson

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(3)

Published: April 21, 2025

Abstract Mesenchymal stem cells (MSCs) and blood plasma/MSC-derived extracellular vesicles (EVs) offer promising tools to promote longevity treat age-related diseases. MSCs have low immunogenicity tumorigenicity, their efficacy is relatively independent of the donor age in humans (but not rodents). Systemic administration cell/blood-derived EVs modified omic profiles various organs aged rodents towards young ones. The application appears be even more beneficial than MSCs. Remarkably, over 70% microRNAs, which are over-presented ESC-derived EVs, were found target longevity-associated genes. Along with MSCs, other types reported display health- lifespan-extending effects. Pluripotent Muse cells, a specific subpopulation possess number unique features, could particularly relevant for promoting healthspan. rejuvenation potential warrants further investigation both animal models clinical trials, using aging clocks biological determination as one endpoints.

Language: Английский

Citations

0
Embryonic Stem Cells and the ‘Last-Minute’ Correction DOI

Khachik K. Muradian,

Vadim E. Fraifeld

Healthy ageing and longevity, Journal Year: 2024, Volume and Issue: unknown, P. 71 - 76

Published: Jan. 1, 2024

Language: Английский

Citations

0
Advances in CAR NK Cell Therapy for Targeting and Eradicating Circulating Tumor Cells: Challenges and Solutions for Aging Patients Mini Review DOI Creative Commons
Dmitri Toren, Eugen Ursu, Bogdan Ghilic-Micu

et al.

Ageing & Longevity, Journal Year: 2024, Volume and Issue: 4 2024, P. 157 - 173

Published: Nov. 11, 2024

Chimeric Antigen Receptor (CAR) Natural Killer (NK) cells represent a promising advancement in cancer immunotherapy, particularly for targeting circulating tumor (CTCs) and preventing metastasis. This review examines the latest developments CAR NK cell therapy, including diverse sources, genetic engineering techniques, dual mechanisms of action. Targeting CTCs with shows significant potential aggressive cancers like triple-negative breast (TNBC) pancreatic cancer. The impact aging on function, especially regarding cytotoxicity, cytokine secretion, persistence, poses challenges elderly patients, but strategies such as interleukin-15 metabolic interventions offer solutions. also addresses current limitations, poor persistence immunosuppressive microenvironments low solid infiltration, while proposing combination therapies to enhance effectiveness. Although still earlier clinical stages compared T cells, cells’ safety profile MHC-independent recognition make them versatile therapeutic option. Future directions include optimizing improving developing age-adapted patients. _________________________________________________________________________________________ Keywords: Circulating (CTCs), Cell Therapy, Aging

Language: Английский

Citations

0
Dual role of extracellular vesicles in neurodegenerative diseases DOI
Arianna Scuteri, E Donzelli

World Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 16(12), P. 1002 - 1011

Published: Dec. 12, 2024

Extracellular vesicles (EVs) are cell-to-cell interaction tools that attracting increasing interest in the literature two opposing areas. In addition to their role physiological development, there is growing evidence of involvement healing and protective processes. However, EVs also mediate pathological conditions, particularly contributing progression several chronic diseases, such as neurodegenerative diseases. On other hand, form core a new therapeutic strategy for neuroprotection, which based on administration derived from wide range donor cells. particular, possibility obtaining numerous stem cells different origins, feasible aims, now under investigation. this review, we focused could have propagative detrimental effect or be exploited deliver factors. This review explores hypotheses concerning dual EVs, with aim shedding light following question: Can used fight vesicle-propagated diseases?

Language: Английский

Citations

0