The Critical Role of Autophagy and Phagocytosis in the Aging Brain DOI Open Access
Stephen C. Bondy,

Meixia Wu

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 57 - 57

Published: Dec. 25, 2024

As the organism ages, there is a decline in effective energy supply, and this retards ability to elaborate new proteins. The consequences of are especially marked gradual brain function. senescence cells their constituent organelles ultimately cause aging entire nervous system. What less immediately obvious that also accompanied by failure catabolic events lead removal non-functional ineffective subcellular components. non-working cellular elements within essential order allow appearance fresh with full range capacities. Thus, maintenance operative mechanisms for dispersal failed tissue components important, its diminished capacity significant contributory factor onset progression age-related neurological disorder. This report discusses underlying autophagy phagocytosis how these can be adversely modulated as proceeds. means which recycling may reinstated aged considered.

Language: Английский

Promotion of healthy aging through the nexus of gut microbiota and dietary phytochemicals DOI Creative Commons
Laura M. Beaver, Paige Jamieson, Carmen P. Wong

et al.

Advances in Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 100376 - 100376

Published: Jan. 1, 2025

Aging is associated with the decline of tissue and cellular functions, which can promote development age-related diseases like cancer, cardiovascular disease, neurodegeneration, disorders musculoskeletal immune systems. Healthspan length time an individual in good health free from chronic disabilities aging. Two modifiable factors that influence healthspan, healthy aging, prevent diseases, are diet microbiota gastrointestinal tract (gut microbiota). This review will discuss how dietary phytochemicals gut work concert to a First overview provided influences aging through its impact on barrier integrity, function, mitochondria function oxidative stress. Next, mechanisms by effect health, inflammation, nurture diverse microbial composition discussed. Lastly, directly producing bioactive metabolites food urolithin A, equol, hesperetin sulforaphane. These other phytochemical derived may healthspan Importantly, individual's capacity produce promoting cruciferous vegetables, berries, nuts, citrus soy products be dependent specific bacteria present gut.

Language: Английский

Citations

3
Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota DOI Creative Commons
Yanbo Liu, Ying Zhou, Haoyue Zhang

et al.

Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104964 - 104964

Published: April 8, 2025

The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.

Language: Английский

Citations

0
Urolithins: Emerging natural compound targeting castration-resistant prostate cancer (CRPC) DOI
Ajit Kumar Navin, Chalikkaran Thilakan Rejani, Balaji Chandrasekaran

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118058 - 118058

Published: April 19, 2025

Language: Английский

Citations

0
Urolithin A prevents age-related hearing loss in C57BL/6J mice likely by inducing mitophagy DOI Creative Commons
Sung Il Cho, Eu-Ri Jo,

Hee Sun Jang

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 197, P. 112589 - 112589

Published: Sept. 24, 2024

Mitochondrial dysfunction with aging is associated the development of age-related hearing loss. Mitophagy a cardinal mechanism to maintain healthy mitochondrial population through turnover damaged mitochondria. Declining mitophagy age causes buildup mitochondria, leading sensory organ dysfunction. The effect Urolithin A (UA), inducer, was investigated on loss in mouse model. C57BL/6J mice were treated UA from 6 10 months age. attenuated an auditory brainstem responses (ABR) threshold shift at 8, 16, and 32 kHz frequencies, improved DNA integrity ATP production cochlea cortex. mRNA levels mitophagy-related genes protein PINK1, Parkin, BNIP3, LC3B increased expression mitophagosomes mitophagolysosomes cochlea, spiral ganglion, cortex, inferior colliculus increased, together Parkin BNIP3 colliculus. These results indicate that counteracted decline system prevented can be used as potential agent prevent

Language: Английский

Citations

3
Protective role of mitophagy on microglia-mediated neuroinflammatory injury through mtDNA-STING signaling in manganese-induced parkinsonism DOI Creative Commons
Lu Yang, Liang Gao, Yuqing Yang

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 28, 2025

Manganese (Mn), the third most abundant transition metal in earth's crust, has widespread applications emerging field of organometallic catalysis and traditional industries. Excessive Mn exposure causes neurological syndrome resembling Parkinson's disease (PD). The pathogenesis PD is thought to involve microglia-mediated neuroinflammatory injury, with mitochondrial dysfunction playing a role aberrant microglial activation. In early stages PD, PINK1/Parkin-mediated mitophagy contributes inflammatory response via cGAS/STING signaling pathway. Suppression due excessive exacerbates neuronal injury. Moreover, leads damage cGAS-STING However, precise modulating neuroinflammation Mn-induced parkinsonism its underlying molecular mechanism remains unclear. Here, we observed that Mn-exposed mice exhibited neurobehavioral abnormalities detrimental activation, along increased apoptosis nerve cells, proinflammatory cytokines, intracellular ROS. Furthermore, vivo vitro experiments showed resulted dysfunction, manifested by ROS, decreased mass, membrane potential. Additionally, escalating dose, changed from activation suppression. This was evidenced levels LC3-II, PINK1, p-Parkin/Parkin, p62 protein expression level, as well colocalization between ATPB LC3B exposure. Upregulation urolithin A could mitigate indicated potential, improvements deficits attenuated Using single-nucleus RNA-sequencing (snRNA-seq) analysis mouse model, identified pathway potential neuroinflammation. associated an increase cytosolic mtDNA levels, which activate STING signaling. These findings point induction viable strategy alleviate through mtDNA-STING

Language: Английский

Citations

0
Urolithin as a Metabolite of Ellagitannins and Ellagic Acid from Fruits and Nuts Produced by the Gut Microbiota: Its Role on Non-Communicable Diseases DOI
Márcia Ribeiro, Lívia Alvarenga, L. Cardozo

et al.

Current Nutrition Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: April 3, 2025

Language: Английский

Citations

0
Towards Precision Geromedicine in Singapore DOI Creative Commons

Jonas John Posko Amalaraj,

Louis Island,

Jane Yu Ying Ong

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

Citations

0
Impact of Fruit Consumption on Gut Microbiota: Benefits, Contaminants, and Implications for Human Health DOI

Débora Fernandes Pinheiro,

Giselle Maria Maciel, Nayara Pereira Lima

et al.

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 154, P. 104785 - 104785

Published: Nov. 12, 2024

Language: Английский

Citations

1
Urolithin A and nicotinamide riboside differentially regulate innate immune defenses and metabolism in human microglial cells DOI Creative Commons
Helena Borland Madsen, Cláudia Maria Navarro,

Emilie Gasparini

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Nov. 27, 2024

During aging, many cellular processes, such as autophagic clearance, DNA repair, mitochondrial health, metabolism, nicotinamide adenine dinucleotide (NAD+) levels, and immunological responses, become compromised. Urolithin A (UA) Nicotinamide Riboside (NR) are two naturally occurring compounds known for their anti-inflammatory protective properties, yet the effects of these natural substances on microglia cells have not been thoroughly investigated. As both UA NR considered safe dietary supplements, it is equally important to understand function in normal disease states.

Language: Английский

Citations

0
The Critical Role of Autophagy and Phagocytosis in the Aging Brain DOI Open Access
Stephen C. Bondy,

Meixia Wu

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 57 - 57

Published: Dec. 25, 2024

As the organism ages, there is a decline in effective energy supply, and this retards ability to elaborate new proteins. The consequences of are especially marked gradual brain function. senescence cells their constituent organelles ultimately cause aging entire nervous system. What less immediately obvious that also accompanied by failure catabolic events lead removal non-functional ineffective subcellular components. non-working cellular elements within essential order allow appearance fresh with full range capacities. Thus, maintenance operative mechanisms for dispersal failed tissue components important, its diminished capacity significant contributory factor onset progression age-related neurological disorder. This report discusses underlying autophagy phagocytosis how these can be adversely modulated as proceeds. means which recycling may reinstated aged considered.

Language: Английский

Citations

0