The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms DOI Open Access
Daniel Guerreiro Diniz, João Bento‐Torres, Victor Oliveira da Costa

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10757 - 10757

Published: Oct. 6, 2024

With the aging of global population, neurodegenerative diseases are emerging as a major public health issue. The adoption less sedentary lifestyle has been shown to have beneficial effect on cognitive decline, but molecular mechanisms responsible clear. Here we provide detailed analysis complex molecular, cellular, and systemic underlying age-related decline how choices influence these processes. A review evidence from animal models, human studies, postmortem analyses emphasizes importance integrating physical exercise with cognitive, multisensory, motor stimulation part multifaceted approach mitigating decline. We highlight potential non-pharmacological interventions address key hallmarks, such genomic instability, telomere attrition, neuroinflammation, underscore need for comprehensive personalized strategies promote resilience healthy aging.

Language: Английский

Addressing cognitive impairment in hypertensive patients: Risk factors and clinical implications DOI
Yetty Morelent,

Santi Tri Meilina,

Hidayati Azkiya

et al.

Journal of Clinical Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 111105 - 111105

Published: Feb. 1, 2025

Language: Английский

Citations

0
The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms DOI Open Access
Daniel Guerreiro Diniz, João Bento‐Torres, Victor Oliveira da Costa

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10757 - 10757

Published: Oct. 6, 2024

With the aging of global population, neurodegenerative diseases are emerging as a major public health issue. The adoption less sedentary lifestyle has been shown to have beneficial effect on cognitive decline, but molecular mechanisms responsible clear. Here we provide detailed analysis complex molecular, cellular, and systemic underlying age-related decline how choices influence these processes. A review evidence from animal models, human studies, postmortem analyses emphasizes importance integrating physical exercise with cognitive, multisensory, motor stimulation part multifaceted approach mitigating decline. We highlight potential non-pharmacological interventions address key hallmarks, such genomic instability, telomere attrition, neuroinflammation, underscore need for comprehensive personalized strategies promote resilience healthy aging.

Language: Английский

Citations

3