A Tea Polyphenol-Infused Sprayable Thermosensitive Liposomal Hydrogel for Enhanced Anti-Inflammatory and Antibacterial Psoriasis Treatment

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(4), P. 124 - 124

Published: April 1, 2025

Psoriasis is a chronic and recurrent inflammatory disease driven not only by intrinsic factors such as immune system dysregulation but also external factors, including bacterial infections. In contrast to the control of single pathogenic pathway, combination therapies addressing both infectious components psoriasis pathogenesis may offer more effective strategy for controlling its progression. this study, we developed sprayable hydrogel incorporating tea polyphenol-loaded lauric acid liposomes (TP@LA-Lipo gel) investigate anti-inflammatory antibacterial role in psoriasis. Our results demonstrated that TP@LA-Lipo modulated macrophage activity, reduced expression iNOS TNF-α, remodeled microenvironment. Meanwhile, effectively eliminated Staphylococcus aureus Escherichia coli through membrane disruption, mitigating provoked response. More importantly, gel, when sprayed onto lesions, provided sustained drug release over three days, enabling deeper penetration thickened stratum corneum reach inflamed layers beneath. Furthermore, an imiquimod-induced mouse model, gel restored damaged skin, alleviated histopathological changes, systemic summary, these findings indicate offers comprehensive management improving quality life patients.

Language: Английский

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Potential Relationship Between Helicobacter pylori Infection and Autoimmune Disorders: A Narrative Review

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107572 - 107572

Published: April 1, 2025

Language: Английский

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Ultra-Processed Food Consumption and the Risk of Psoriasis: A Large Prospective Cohort Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1473 - 1473

Published: April 27, 2025

Background: The sales of ultra-processed food (UPF) are rapidly increasing worldwide, and there have been reports linking UPF consumption to several chronic diseases. However, is limited prospective evidence exploring the impact on inflammatory skin Objectives: This study investigates association between intake incidence psoriasis using data from UK Biobank. Methods: UPFs were assessed based NOVA classification in this large study. Cox proportional hazards regression was employed estimate incident risk psoriasis. Inflammation score (INFLA-score) body mass index (BMI) chosen as mediators examine mediation effect. Substitution analysis performed when replacing absolute amount with an equivalent weight unprocessed or minimally processed food. Results: enrolled 121,019 participants aged 40–69 years Over a 12-year (median) follow-up period, 1043 developed In fully adjusted model, hazard ratios (95% confidence interval) for across quartiles 1.00 (reference), 1.07 (0.89, 1.28), 1.19 (1.00, 1.42), 1.23 (1.03, 1.47), respectively (p trend = 0.016). Factors such age, sex, BMI, smoking status, drinking physical activity level, Townsend Deprivation Index (TDI) did not significantly modify interaction > 0.05). INFLA-score BMI explained 6.5% 0.012) 30.5% < 0.001) risk, respectively. Replacing 20% total diet proportion foods associated 18% reduction (HR: 0.82; 95% CI: 0.72–0.94; p 0.004). Conclusions: Our findings indicate that increased higher provides valuable dietary guidance preventing its related comorbidities.

Language: Английский

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Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome

Clinical Reviews in Allergy & Immunology, Journal Year: 2024, Volume and Issue: 66(3), P. 294 - 315

Published: July 2, 2024

Language: Английский

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Gut microbiome and Alzheimer’s disease: what we know and what remains to be explored

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102570 - 102570

Published: Oct. 31, 2024

Language: Английский

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Anti-Psoriatic Activity of Black, Green and White Tea Extracts from Southeastern China

Molecules, Journal Year: 2024, Volume and Issue: 29(6), P. 1279 - 1279

Published: March 13, 2024

Psoriasis is a common chronic inflammatory disease, but most of its current treatments come with high risk side effects. As one the world’s top three beverages, tea has traditional history being used as treatment for skin conditions due to safety profile, anti-inflammatory and other properties. In this study, we investigated anti-psoriasis effects ethanol extracts black tea, green white from southeastern China. The compositions (TEs) were first determined by UPLC-Q-Exactive-Orbitrap MS then genetic analysis, antibacterial, anti-inflammatory, immunocompetence assays performed. Imiquimod was establish mouse model psoriasis-like dermatitis treating examine their efficacy. A total 88 chemical components, mainly phenols organic acids, identified TEs. These TEs ameliorated damage they all reduced expression cytokines IL-17 TNF-α. By analyzing genes, may affect signaling pathway regulating metabolic changes. addition, can significantly scavenge ROS, NO, inhibit cellular inflammation. conclusion, study examined inhibitory on psoriasis potential nutritional supplements

Language: Английский

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Bacterial consortia-The latest arsenal to inflammatory bowel disease bacteriotherapy

Medicine in Microecology, Journal Year: 2024, Volume and Issue: 20, P. 100107 - 100107

Published: April 10, 2024

The microbiota based dietary interventions have emerged as an unconventional bacteriotherapeutic approach for the treatment of a plethora pathological conditions including inflammatory bowel disease. potential side effects associated with use probiotics include systemic infections, deleterious metabolic activities, excessive immune stimulation in susceptible individuals and gene transfer. Moreover, probiotic strains are not very specific offering health benefits it is generally considered that group such bacteria more effective than single strain. Based on this assumption, fecal matter transplantation was proposed better alternative. Despite proving to be certain diseases, has found wide acceptability because its poor aesthetic appeal, risk infection transmission, challenges standardization regulation policies. Bacterial consortia, however, emerge multi-strain, biotherapeutic agents known composition free from any infections or uncertain processes. These complex microbial communities having ecological interactions among themselves. While therapeutic profile similar transplantation, bacterial consortia effects. demonstrated significant effectiveness irritable syndrome. Inflammatory disease represents multifactorial ailments comprising both ulcerative colitis Crohn's It attributed disturbance immunological environmental factors while genetic also play their role. Among all above, changes gut (dysbiosis) main causative agent etiology Therefore, changing through consortium offers realistic option In review, we decipher relationship between dysbiosis pathogenesis We discuss various regarding therapy. Diving deeper, pre-clinical clinical studies conducted hitherto described. limitations emerging discussed. Considering worldwide prevalence constant struggle find safe, economical convenient cure it, could attractive strategy.

Language: Английский

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Phenylalanine Butyramide: A Butyrate Derivative as a Novel Inhibitor of Tyrosinase

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7310 - 7310

Published: July 3, 2024

Metabolites resulting from the bacterial fermentation of dietary fibers, such as short-chain fatty acids, especially butyrate, play important roles in maintaining gut health and regulating various biological effects skin. However, butyrate is underutilized due to its unpleasant odor. To circumvent this organoleptic unfavorable property, phenylalanine butyramide (PBA), a precursor, has been synthesized currently available on market. We evaluated inhibition mushroom tyrosinase by PBA through vitro assays, finding IC50 values 34.7 mM 120.3 mM, respectively. Docking calculations using homology model human identified putative binding mode into catalytic site. The anti-aging anti-spot efficacy topical was randomized, double-blind, parallel-arm, placebo-controlled clinical trial involving 43 women affected photo-damage. results study showed that significantly improved skin conditions compared placebo well tolerated. Specifically, demonstrated strong depigmenting activity both UV brown spots (UV: -12.7% -9.9%, Bs: -20.8% -17.7% after 15 30 days, respectively, p < 0.001). Moreover, brightened lightened (ITA°: +12% 13% Finally, elasticity (Ua/Uf: +12.4% +32.3% 0.001) firmness (Uf: -3.2% -14.9% 0.01).

Language: Английский

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Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 20, 2023

The organ-specific microbiome plays a crucial role in tissue homeostasis, among other things by inducing regulatory T cells (Treg). This applies also to the skin and this setting short chain fatty acids (SCFA) are relevant. It was demonstrated that topical application of SCFA controls inflammatory response psoriasis-like imiquimod (IMQ)-induced murine inflammation model. Since signal via HCA2, G-protein coupled receptor, HCA2 expression is reduced human lesional psoriatic skin, we studied effect knock-out (HCA2-KO) mice reacted IMQ with stronger inflammation, presumably due an impaired function Treg. Surprisingly, injection Treg from HCA2-KO even enhanced reaction, suggesting absence switch suppressive into proinflammatory type. differed composition wild type mice. Co-housing reversed exaggerated prevented alteration Treg, implying dictates outcome reaction. could be downstream phenomenon. opens opportunity reduce tendency psoriasis altering microbiome.

Language: Английский

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Aktuelle Entwicklungen und Perspektiven bei Psoriasis

JDDG Journal der Deutschen Dermatologischen Gesellschaft, Journal Year: 2023, Volume and Issue: 21(4), P. 363 - 373

Published: April 1, 2023

Zusammenfassung Die Erforschung kaum einer anderen Erkrankung hat so grundlegend neue Erkenntnisse über immunologischen Regulationen und gleichzeitig eine derart rasante Entwicklung innovativer Therapien hervorgebracht wie das Studium der Psoriasis. In dieser kurzen Übersichtsarbeit umreißen wir die Grundzüge aktuellen Psoriasisforschung unter besonderer Berücksichtigung pathophysiologischer Vorgänge Meilensteine bei Zulassung verschiedener Biologika niedermolekularer Pharmaka. Nicht zuletzt durch verstehen Zusammenspiel Komponenten des angeborenen adaptiven Immunsystems immer besser. Neue Therapeutika greifen dabei an entscheidenden Punkten in regulatorische Netzwerke ein. Ausgehend vom derzeitigen Kenntnisstand skizzieren einige aus unserer Sicht wesentliche zukünftige Forschungsrichtungen sowie therapeutische klinische Entwicklungen im Bereich Diese reichen von genetischer, epigenetischer, zellulärer immunologischer Mechanismen Untersuchung spezifischer klinischer Formen Psoriasis individueller systemischer Auswirkungen Krankheit ihrer Behandlung bis hin zur Einbeziehung Big Data künstlicher Intelligenz. Ziele sind ein ganzheitliches Verständnis molekularen organismischen gesellschaftlichen Ebene darauf aufbauend individualisierte Präventions‐ Behandlungsstrategien. Trotz beeindruckender Fortschritte muss sowohl kleinen als auch großen Maßstab weiterentwickelt werden, um den Bedürfnissen Behandlern Patienten noch besser gerecht zu werden.

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