Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Sept. 6, 2023
Abstract
Background
Rapid
progressive
interstitial
lung
disease
(RP-ILD)
is
the
leading
cause
of
anti-melanoma
differentiation
associated
protein
5
antibody
positive
dermatomyositis
(anti-MDA5
+
DM)
related
death.
Elevated
serum
B-cell
activating
factor
(BAFF)
levels
have
been
implicated
in
connective
tissue
diseases
ILD.
Here,
we
evaluate
whether
BAFF
could
be
a
prognostic
biomarker
for
predicting
RP-ILD
anti-MDA5
DM
patients.
Methods
Serums
were
collected
from
39
patients
with
(20
and
19
non-RP-ILD),
20
antisynthase
syndrome
(ASS)
healthy
controls
(HC).
concentration
was
measured
by
an
enzyme-linked
immunosorbent
assay.
Results
Serum
level
higher
than
those
ASS
HC
(3882.32
±
1880.09
vs.
2540.89
1403.04
2486.28
767.97
pg/mL,
p
=
0.0056
0.0038,
respectively).
Within
groups,
exhibited
non-RP-ILD
group
(4549.78
1839.97
3297.28
1794.69
0.04).
The
positively
correlated
C-reactive
(CRP),
dehydrogenase
(LDH)
cytokeratin
(CK)
(
r
0.350,
0.035;
0.393,
0.016;
0.518,
0.001;
best
cut-off
value
2971.5
pg/mL
ROC
curve
(AUC
area
0.690,
0.045)
>
independent
risk
using
multivariate
analysis
(OR
9.389,
95%
CI
1.609
-
54.769;
0.013).
Conclusions
useful
early
detecting
Immunological Reviews,
Journal Year:
2023,
Volume and Issue:
321(1), P. 246 - 262
Published: Oct. 12, 2023
Summary
Cell
death
can
be
executed
through
distinct
subroutines.
PANoptosis
is
a
unique
inflammatory
cell
modality
involving
the
interactions
between
pyroptosis,
apoptosis,
and
necroptosis,
which
mediated
by
multifaceted
PANoptosome
complexes
assembled
via
integrating
components
from
other
modalities.
There
growing
interest
in
process
function
of
PANoptosis.
Accumulating
evidence
suggests
that
occurs
under
diverse
stimuli,
for
example,
viral
or
bacterial
infection,
cytokine
storm,
cancer.
Given
impact
across
disease
spectrum,
this
review
briefly
describes
relationships
highlights
key
molecules
formation
activation,
outlines
roles
diseases
together
with
potential
therapeutic
targeting.
We
also
discuss
important
concepts
pressing
issues
future
research.
Improved
understanding
its
mechanisms
crucial
identifying
novel
targets
strategies.
Phytotherapy Research,
Journal Year:
2023,
Volume and Issue:
37(11), P. 4999 - 5016
Published: July 25, 2023
Abstract
Numerous
pharmacological
effects
of
quercetin
have
been
illustrated,
including
antiinflammation,
antioxidation,
and
anticancer
properties.
In
recent
years,
the
antioxidant
activity
has
extensively
reported,
in
particular,
its
impacts
on
glutathione,
enzyme
activity,
signaling
transduction
pathways,
reactive
oxygen
species
(ROS).
Quercetin
also
demonstrated
to
exert
a
striking
antiinflammatory
effect
mainly
by
inhibiting
production
cytokines,
reducing
expression
cyclooxygenase
lipoxygenase,
preserving
integrity
mast
cells.
By
regulating
oxidative
stress
inflammation,
which
are
regarded
as
two
critical
processes
involved
defense
regular
physiological
operation
biological
systems,
validated
be
effective
treating
variety
disorders.
Symptoms
these
reactions
linked
degenerative
metabolic
disorders,
syndrome,
cardiovascular,
neurodegeneration,
cancer,
nonalcoholic
fatty
liver
disease.
Despite
that
evidence
demonstrates
antioxidants
employed
prevent
excessive
inflammatory
processes,
there
still
concerns
regarding
expense,
accessibility,
side
agents.
Notably,
natural
products,
especially
those
derived
from
plants,
widely
accessible,
affordable,
generally
safe.
this
review,
abilities
active
ingredient
application
stress‐related
disorders
outlined
detail.
Autoimmunity Reviews,
Journal Year:
2023,
Volume and Issue:
22(6), P. 103334 - 103334
Published: April 15, 2023
Idiopathic
inflammatory
myopathies
(IIM),
even
though
sharing
common
clinical
manifestations,
are
characterized
by
diversified
molecular
pathogenetic
mechanisms
which
may
account
for
the
partial
inefficacy
of
currently
used
immunomodulatory
drugs.
In
last
decades,
role
interferon
(IFN)
in
IIM
has
been
extensively
elucidated
thanks
to
genomic
and
proteomic
studies
have
assessed
signature
at
level
affected
tissues
or
peripheral
blood
across
distinct
subtypes.
A
predominant
type
I
IFN
response
shown
dermatomyositis
(DM),
being
especially
enhanced
anti-melanoma
differentiation-associated
gene
5
(MDA5)+
DM,
while
a
2
profile
characterizes
anti-synthetase
syndrome
(ASyS)
inclusion
body
myositis
(IBM);
conversely,
less
robust
footprint
defined
immune-mediated
necrotizing
myopathy
(IMNM).
Intracellular
signaling
is
mediated
janus
kinase/signal
transducer
activator
transcription
(JAK/STAT)
through
dedicated
transmembrane
receptors
specific
cytoplasmic
combinations.
These
results
therapeutic
implications
led
evaluating
efficacy
new
targeted
drugs
such
as
recently
introduced
kinase
inhibitors
(JAKi),
approved
treatment
rheumatoid
arthritis,
psoriatic
ankylosing
spondylitis.
this
review
we
aim
summarize
most
significant
evidence
pathogenesis
describe
current
state
art
about
ongoing
trials
on
IFN-targeting
drugs,
with
particular
focus
JAKi.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(20), P. 13249 - 13265
Published: May 9, 2024
The
therapeutic
application
of
mesenchymal
stem
cells
(MSCs)
has
good
potential
as
a
treatment
strategy
for
systemic
lupus
erythematosus
(SLE),
but
traditional
MSC
therapy
still
limitations
in
effectively
modulating
immune
cells.
Herein,
we
present
promising
based
on
dexamethasone
liposome-integrated
MSCs
(Dexlip-MSCs)
treating
SLE
via
multiple
immunomodulatory
pathways.
This
prolonged
the
circulation
time
liposomes
vivo,
restrained
CD4+T-cell
proliferation,
and
inhibited
release
proinflammatory
mediators
(IFN-γ
TNF-α)
by
CD4+T
In
addition,
Dexlip-MSCs
initiated
cellular
reprogramming
activating
glucocorticoid
receptor
(GR)
signaling
pathway
to
upregulate
expression
anti-inflammatory
factors
such
cysteine-rich
secretory
protein
LCCL-containing
domain
2
(CRISPLD2)
downregulate
factors.
synergistically
increased
inhibitory
effect
through
or
Dex-integrated
MSC-derived
exosomes
(Dex-MSC-EXOs).
Based
these
synergistic
biological
effects,
demonstrated
that
alleviated
disease
progression
MRL/lpr
mice
more
than
Dexlip
alone.
These
features
indicate
our
cell
delivery
is
approach
clinical
treatment.
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(3), P. e0317369 - e0317369
Published: March 10, 2025
Background
Papillary
thyroid
carcinoma
coexisting
with
rheumatoid
arthritis
is
frequently
observed
in
clinical
patients,
yet
its
pathogenesis
has
not
been
fully
elucidated.
This
investigation
sought
to
further
explore
the
molecular
underpinnings
of
these
two
diseases.
Methods
Gene
expression
profiles
for
papillary
and
patients
were
obtained
from
Comprehensive
Expression
Database
(GEO).
Following
discovery
shared
differentially
expressed
genes
(DEGs)
between
conditions,
three
separate
analyses
conducted.
These
included
functional
annotation,
establishment
a
protein‒protein
interaction
(PPI)
network
module,
identification
hub
via
coexpression
analysis.
The
final
step
involved
validation
target
specimens.
Results
study
analyzed
datasets
four
GEO
databases
identified
64
common
DEGs.
Functional
enrichment
analysis
revealed
that
are
predominantly
associated
pathways
related
immunity
signal
transduction.
Protein‒protein
complex
interactions
among
highlighted
several
may
play
pivotal
roles
pathological
mechanisms,
namely,
CCR5,
CD4,
IL6,
CXCL13,
FOXM1,
CXCL9,
CXCL10.
Conclusion
Our
highlights
cancer
arthritis.
Shared
crucial
could
offer
novel
perspectives
subsequent
investigations
into
mechanisms
