Causal relationship between gut microbiota and myasthenia gravis: a two-sample Mendelian randomization study DOI Creative Commons

Chuanhao Mi,

Ajiao Hou, Ziyue Wang

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 25, 2024

Background Previous observational studies have provided cumulative data linking gut microbiota to myasthenia gravis (MG). However, the causal link between two remains unexplored. Hence, current study was performed explore them. Methods Mendelian randomization (MR) analysis conducted using summary statistics of 211 taxa and largest genome-wide association (GWAS) for MG currently available. The inverse variance-weighted (IVW), MR-Egger, weighted median, mode methods were employed ascertain influence. Sensitivity utilizing several methodologies then used assess robustness findings. Lastly, evaluate reverse causality, a MR performed. Results Seven suggestive associations gastrointestinal identified based on outcomes analysis. Specifically, phylum Actinobacteria (OR: 0.602, 95% CI: 0.405–0.896, p = 0.012), class Gammaproteobacteria 0.587, 0.357–0.968, 0.037), families Defluviitaleaceae 0.695, 0.485–0.996, 0.047), Family XIII 0.614, 0.412–0.916, 0.017), Peptococcaceae 0.698, 0.505–0.964, 0.029) had protective effects MG, while order Mollicutes RF9 1.424, 1.015–1.998, 0.041) genus Faecalibacterium 1.763, 1.220–2.547, 0.003) risk factors MG. indicate that neither heterogeneity nor horizontal pleiotropy any discernible impact. Nevertheless, this did not reveal apparent effect composition. Conclusion investigation has substantiated connection which may provide helpful insights innovative therapeutic preventative approaches Further randomized controlled trials are needed elucidate microbiota’s precise role potential in pathogenesis

Language: Английский

Benzimidazole Fungicide Carbendazim Induces Gut Inflammation through the TLR5/NF-κB Pathway in Grass Carp DOI
Zhijie Lu, Wenjun Shi,

Lu-Kai Qiao

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Fungicides have been increasingly used across various sectors, including agriculture and textiles. The biocidal properties of fungicides may negatively impact the stability intestinal microbiota, thereby posing a threat to health. In this study, we investigated mechanisms damage functional abnormalities in grass carp following 42-day exposure widely fungicide carbendazim at environmentally relevant concentrations (0.2 20 μg/L). Histopathological observations, mRNA protein expression analyses, biochemical analysis, quantification short-chain fatty acids (SCFAs), cytokines, lipopolysaccharide (LPS), 16S ribosomal ribonucleic acid (rRNA), as well internal transcribed spacer (ITS) sequencing, were performed. At concentrations, strongly induced inflammation, leading increased transcriptional translational levels genes involved toll-like receptor five (TLR5)/nuclear factor kappa B (NF-κB) pathway, TLR5, NF-κB, interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNFα). Additionally, damaged barriers reduced tight junction proteins (e.g., occludin zonula occludens-1/2), goblet cells, immunoglobulin M levels, while also disrupting gut microbiome, metabolic disorders, particularly decreases SCFAs increases LPS. Treatment with TLR5 antagonist TH1020 mitigated inflammation caused by carbendazim, subsequently improving mechanical barrier function. Overall, our findings provide new insights into toxicological underlying carp, indicating that poses significant nontarget organisms. Given its widespread detection environment, these results underscore substantial ecological risks health fish living carbendazim-contaminated water bodies.

Language: Английский

Citations

2
An azole fungicide climbazole damages the gut-brain axis in the grass carp DOI
Zhijie Lu, Wenjun Shi, Fang-Zhou Gao

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 465, P. 133463 - 133463

Published: Jan. 10, 2024

Language: Английский

Citations

7
Probiotics in Allergy and Immunological Diseases: A Comprehensive Review DOI Open Access
Swapna Vijayan,

Venkataramana Kandi,

Pratyusha S Palacholla

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: March 8, 2024

Allergy and immunological disorders like autoimmune diseases are vastly prevalent worldwide. These conditions account for a substantial amount of personal social burden. Such illnesses have lengthy, uncertain, spotted courses with unpredictable exacerbations. A definite tendency improving the overall quality life individuals suffering from such is crucial to tackling these diseases, especially through diet or lifestyle modification. Further, interventions microbiome-based therapeutics as prebiotics probiotics were explored. Changes in microbial population evident during flare-up allergic conditions. The realization that human microbiome central player hallmark its potential usefulness therapy illnesses. This review focuses on intricate symphony orchestra immune system. New therapeutic strategies involving appear be future personalized medicine. Through this review, we explore narrative reaffirm their use preventive agents disorders.

Language: Английский

Citations

7
SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis DOI Creative Commons
Rahul Pandey,

Marina Bakay,

Hákon Hákonarson

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 26, 2023

Autoimmune diseases arise from atypical immune responses that attack self-tissue epitopes, and their development is intricately connected to the disruption of JAK-STAT signaling pathway, where SOCS proteins play crucial roles. Conditions such as autoimmune uveitis, psoriasis, lupus, encephalitis exhibit system dysfunctions associated with dysregulation. Emerging therapeutic strategies utilize inhibitors mimetics modulate alleviate manifestations. Although more research clinical studies are required assess effectiveness, safety profiles, potential for personalized approaches in conditions, show promise treatment options. This review explores action, future prospects JAK agents systemic lupus erythematosus, encephalitis. The findings underscore importance investigating these targeted therapies advance options individuals suffering diseases.

Language: Английский

Citations

16
Gut microbiota and autoimmune neurologic disorders: a two-sample bidirectional Mendelian randomization study DOI Creative Commons
Mengyuan Zhang, Jie Fang,

Chamou Zheng

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: April 24, 2024

Increasing evidence has suggested that alterations in the gut microbiome are correlated with autoimmune neurologic disorders, yet causal relationship between them to be established.

Language: Английский

Citations

4
Gut microbiome and Alzheimer’s disease: what we know and what remains to be explored DOI
Bhupinder Kapoor, Pratim Biswas,

Monica Gulati

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102570 - 102570

Published: Oct. 31, 2024

Language: Английский

Citations

3
Coexistence of Parkinson's disease and myasthenia gravis: A case report and literature review DOI Open Access

Zhijuan Mao,

Nie Qing,

Zheng Xue

et al.

Experimental and Therapeutic Medicine, Journal Year: 2024, Volume and Issue: 28(1)

Published: May 13, 2024

The coexistence of Parkinson's disease (PD) and myasthenia gravis (MG) is rare. When similar symptoms both diseases overlap, it challenging to make a concomitant diagnosis PD MG. present study describes the case patient with In addition, systematic literature review was conducted by searching PubMed Embase for reports on all patients MG, which were then grouped compared according different preexisting diseases. Finally, total 47 cases MG (35 men; 12 women), including case, analyzed. median age at first 66.59±9.91 years. interval between two varied from 2 months 22 Based sequential occurrence these diseases, categorized into three groups: prePD‑MG (30 cases), preMG‑PD (12 coPD‑MG (5 cases) groups. group, onset older head drop more common. likely have comorbid immune

Language: Английский

Citations

2
Machine learning strategy for identifying altered gut microbiomes for diagnostic screening in myasthenia gravis DOI Creative Commons
Che-Cheng Chang, Tzu-Chi Liu, Chi-Jie Lu

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 27, 2023

Myasthenia gravis (MG) is a neuromuscular junction disease with complex pathophysiology and clinical variation for which no clear biomarker has been discovered. We hypothesized that because changes in gut microbiome composition often occur autoimmune diseases, the structures of patients MG would differ from those without, supervised machine learning (ML) analysis strategy could be trained using data microbiota diagnostic screening MG. Genomic DNA stool samples without were collected established sequencing library by constructing amplicon sequence variants (ASVs) completing taxonomic classification each representative sequence. Four ML methods, namely least absolute shrinkage selection operator, extreme gradient boosting (XGBoost), random forest, regression trees nested leave-one-out cross-validation ASV taxon–based full ASV–based to identify key ASVs set. The results revealed XGBoost have best predicted performance. Overlapping features extracted when was identified, 31 high-importance (HIASVs) obtained, assigned importance scores, ranked. most significant difference observed abundance bacteria Lachnospiraceae Ruminococcaceae families. HIASVs used train algorithm differentiate individuals model had high power accurately predict In addition, associated limb weakness severity. this study, we discovered microbiomes differed between non-MG subjects. proposed favorable performance respect analyzing microbiomes. These selected may serve as biomarkers use mechanistic study future. Our can several markers effectively discriminate accuracy, applied benchmark conduct noninvasive

Language: Английский

Citations

6
Advances in Understanding and Managing Myasthenia Gravis: Current Trends and Future Directions DOI Open Access

Shreya Jaiswal,

Tripti Shrivastava

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: April 26, 2024

Myasthenia gravis (MG) is an autoimmune illness characterized by autoantibodies against the acetylcholine receptor (AChR), muscle-specific tyrosine kinase (MuSK), and increasing number of extra postsynaptic proteins. Pathogenic reduce functional AChRs in neuromuscular junction's (NMJ) muscle end plate. The cause response unknown, but thymic abnormalities immune regulatory deficiencies are significant. disease's incidence likely influenced genetic predisposition, with sex hormones exercise playing a role. MG can affect any age, race, or gender be caused stressor, infections being most frequent cause. Treatment focuses on airway support triggering incident. rare disease causing fatigue-inducing weakness axial, respiratory, leg, bulbar muscles. Initially affecting eyes, patients experience at least one worsening symptom during their illness. mainly antibodies AChR, dependence system within cells, engagement complement system. plays significant role MG, inhibition both prevent onset slow its development. Ocular affects around 15% people, having blocking cholinergic receptor. There may correlations between thymoma other conditions, especially thyroid management for involve removing from circulation effector mechanisms using techniques such as inhibition, plasmapheresis, B-cell elimination.

Language: Английский

Citations

1
Mechanism of Ligilactobacillus salivarius GX118 in Regulating the Growth of Rainbow Trout (Oncorhynchus mykiss) and Resistance to Aeromonas salmonicida Infection DOI Creative Commons
X. Cao, Bowen Wang, Wenhao Ren

et al.

Fishes, Journal Year: 2024, Volume and Issue: 9(5), P. 157 - 157

Published: April 27, 2024

Lactic acid bacteria Ligilactobacillus salivarius has been shown to be a substitute for antibiotics in the treatment of bacterial disease high animals. However, its beneficial mechanism fish farming is still unclear. This study evaluated antagonistic effects GX118 strain on Aeromonas salmonicida and regulation rainbow trout growth vivo vitro. The results found that produces an antibacterial substance can directly destroy cell wall A. salmonicida. Whole-genome sequencing revealed Enterolysin A type III bacteriocin with properties. An experiment showed supplementation diet competitively inhibited colonization intestine. In addition, it was able improve performance within 21-day feeding experiment. increased diversity gut microbiota, which abundance Bacteroidota, Blautia, Rhodobacteraceae increased. use activated expression IFN-γ NF-κB genes reduced level IL-6 IL-8, thus exhibiting certain effect activating immunity trout. provides scientific basis development probiotics healthy

Language: Английский

Citations

1