Targeting ferroptosis opens new avenues for the development of novel therapeutics

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Sept. 21, 2023

Abstract Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics, including altered iron homeostasis, reduced defense against oxidative stress, and abnormal lipid peroxidation. Recent studies have provided compelling evidence supporting the notion that ferroptosis plays a key pathogenic role in many diseases such as various cancer types, neurodegenerative disease, involving tissue and/or organ injury, inflammatory infectious diseases. Although precise regulatory networks underlie are largely unknown, particularly respect to initiation progression diseases, recognized bona fide target for further development treatment prevention strategies. Over past decade, considerable progress has been made developing pharmacological agonists antagonists these ferroptosis-related conditions. Here, we provide detailed overview our current knowledge regarding ferroptosis, its pathological roles, regulation during disease progression. Focusing on use chemical tools preclinical studies, also summarize recent advances targeting across growing spectrum ferroptosis-associated Finally, discuss new challenges opportunities potential strategy treating

Language: Английский

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Targeting the regulation of iron homeostasis as a potential therapeutic strategy for nonalcoholic fatty liver disease

Metabolism, Journal Year: 2024, Volume and Issue: 157, P. 155953 - 155953

Published: June 15, 2024

Language: Английский

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A Systematic Review of Statins for the Treatment of Nonalcoholic Steatohepatitis: Safety, Efficacy, and Mechanism of Action

Molecules, Journal Year: 2024, Volume and Issue: 29(8), P. 1859 - 1859

Published: April 19, 2024

Nonalcoholic fatty liver disease (NAFLD) is the component of a cluster conditions, while its subtype, nonalcoholic steatohepatitis (NASH), emerges as potentially progressive disorder that harbors risk evolving into cirrhosis and culminating in hepatocellular carcinoma (HCC). NASH cardiovascular (CVD) have common factors, but compared to liver-related causes, most cause death patients CVD. Within pharmacological armamentarium, statins, celebrated for their lipid-modulating prowess, now garnered attention expansive therapeutic potential NASH. Evidence from plethora studies suggests statins not only manifest anti-inflammatory antifibrotic properties also impart multifaceted beneficial impact on hepatic health. In this review, we used “statin”, “NAFLD”, “NASH”, “CVD” major keywords conducted literature search using PubMed Web Science databases determine safety efficacy animals with NAFLD, mechanism statin therapy Simultaneously, reviewed important role intestinal microbiota NASH, it hoped will provide new insights modulating harmful inflammatory gut reducing systemic inflammation patients.

Language: Английский

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Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(4), P. 2238 - 2263

Published: Feb. 2, 2024

Ferroptosis is a type of iron-dependent programmed cell death characterized by the dysregulation iron metabolism and accumulation lipid peroxides. This nonapoptotic mode implicated in various physiological pathological processes. Recent findings have underscored its potential as an innovative strategy for cancer treatment, particularly against recalcitrant malignancies that are resistant to conventional therapies. article focuses on ferroptosis-based therapeutic strategies precision covering molecular mechanisms ferroptosis, four major types ferroptosis inducers their inhibitory effects diverse carcinomas, detection fluorescent probes, implementation image-guided therapy. These state-of-the-art tactics manifested enhanced selectivity efficacy malignant carcinomas. Given administration therapy still at burgeoning stage, some challenges future perspectives discussed clinical translation into treatment.

Language: Английский

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Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2485 - 2529

Published: June 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Language: Английский

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Ferroptosis in organ fibrosis: From mechanisms to therapeutic medicines

Journal of Translational Internal Medicine, Journal Year: 2024, Volume and Issue: 12(1), P. 22 - 34

Published: Feb. 1, 2024

Abstract Fibrosis occurs in many organs, and its sustained progress can lead to organ destruction malfunction. Although numerous studies on fibrosis have been carried out, underlying mechanism is largely unknown, no ideal treatment currently available. Ferroptosis an iron-dependent process of programmed cell death that characterized by lipid peroxidation. In the past decade, a growing body evidence demonstrated association between ferroptosis fibrotic diseases, while targeting may serve as potential therapeutic strategy. This review highlights recent advances crosstalk fibrosis, discusses ferroptosis-targeted approaches against are being explored.

Language: Английский

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Ferroptosis in organ fibrosis: Mechanisms and therapeutic approaches

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 151, P. 114341 - 114341

Published: March 1, 2025

Language: Английский

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Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 352 - 352

Published: March 15, 2024

Ferroptosis is an emerging type of regulated cell death usually accompanied by the accumulation ferrous ions (Fe2+) and lipid peroxides. As metabolic hub body, liver crucial for iron storage metabolism. The seems to be closely related ferroptosis through Liver disease greatly threatens host health, exploring effective interventions essential. Mounting studies have demonstrated that one possible pathogenic mechanisms involved in disease. Targeting may provide a promising opportunity treating However, drugs targeting are extremely limited. Therefore, it urgent need develop new safe regulators. Natural active compounds (NAC), especially those derived from traditional Chinese medicine, recently shown great therapeutic potential via modulating ferroptosis-related genes or pathways. Here, we outline molecular mechanism systematically summarize regulatory function NAC on Finally, discuss application prospects problems concerning as regulators managing

Language: Английский

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LncRNA FRMD6‐AS1/miR‐491‐5p/USP13 pathway attenuated ferroptosis and contributed to liver fibrosis

Environmental Toxicology, Journal Year: 2024, Volume and Issue: 39(6), P. 3760 - 3771

Published: April 1, 2024

Liver fibrosis is an invertible pathophysiologic process featured by excessive accumulation of extracellular matrix (ECM) which injures liver cells and activates hepatic stellate (HSCs). Besides, inducing ferroptosis in activated HSCs can alleviate fibrosis. LncRNAs modulate ECM deposition However, the role lncRNA FRMD6-AS1 not discovered. In this study, was dramatically up-regulated HSCs. Knockdown markedly increased iron ion, ROS MDA levels, decreased GSH level, SLC7A11 GPX4 protein expressions addition, activation markers α-SMA COL1α1 were HSCs; knockdown down-regulated could interact with miR-491-5p, negatively miR-491-5p expression. USP13 a target be modulated miR-491-5p. Moreover, ion expressions, facilitated viability, via miR-491-5p/USP13 pathway. Finally, restored tissue structure abrogated livers CCL4 mouse model. Hence, FRMD6-AS1/miR-491-5p/USP13 pathway repressed ferroptosis, promoted vitro vivo models.

Language: Английский

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Mechanisms and therapeutic target of anti-tumour treatment-related Ferroptosis: How to improve cancer therapy?

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117323 - 117323

Published: Aug. 28, 2024

Recently, increased attention has been focused on the regulatory mechanism and potential clinical application of ferroptosis in cancer cells, especially therapy-related ferroptosis. However, treatment-related prospects strategies for future treatment still require further clarification. This review highlights molecular relationships between different antitumour drugs, including commonly used chemotherapy radiation therapy vitamins, also proposes treatments that involve ferroptosis, with an aim to develop a new strategy transformative emerging field improve therapy.

Language: Английский

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