Experimental Cell Research, Journal Year: 2024, Volume and Issue: 444(2), P. 114392 - 114392
Published: Dec. 20, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 10, 2025
Lactate, long viewed as a byproduct of glycolysis and metabolic waste. Initially identified within the context yogurt fermentation, lactate's role extends beyond culinary applications to its significance in biochemical processes. Contemporary research reveals that lactate functions not merely terminal product but also nexus for initiating physiological pathological responses body. Lysine lactylation (Kla), novel post-translational modification (PTM) proteins, has emerged pivotal mechanism by which exerts regulatory influence. This epigenetic potential alter gene expression patterns, thereby impacting Increasing evidence indicates correlation between adverse prognosis various malignancies. Consequently, this review article aims encapsulate proteins interact with lactate, elucidate tumorigenesis progression, explore therapeutic targets afforded modulation lactylation. The objective is clarify oncogenic provide strategic framework future directions burgeoning field.
Language: Английский
Citations
1
Chemical Papers, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 20, 2025
Language: Английский
Citations
1
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 116982 - 116982
Published: June 20, 2024
Lactylation is a novel post-translational modification (PTM) involving proteins that induced by lactate accumulation. Histone lysine lactylation alters chromatin spatial configuration, influencing gene transcription and regulating the expression of associated genes. This plays crucial role as an epigenetic regulatory factor in progression various diseases. Glycolytic reprogramming one most extensively studied forms metabolic reprogramming, recognized key hallmark cancer cells. It characterized increase glycolysis inhibition tricarboxylic acid (TCA) cycle, accompanied significant production The two processes are closely linked lactate, which interacts physiological pathological processes. On hand, levels generally correlate positively with extent glycolytic being directly influenced concentration produced during reprogramming. other can also regulate pathways affecting structural functions essential enzymes. review comprehensively outlines mechanisms their interactions tumor progression, immunity, inflammation, aim elucidating relationship between lactylation.
Language: Английский
Citations
7
Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 156234 - 156234
Published: March 1, 2025
Language: Английский
Citations
0
Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116879 - 116879
Published: March 1, 2025
Language: Английский
Citations
0
Cellular Oncology, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3469 - 3469
Published: April 8, 2025
Metabolic diseases, including cardiovascular type 2 diabetes mellitus (T2DM), osteoporosis, and non-alcoholic fatty liver disease (NAFLD), constitute a major global health burden associated with chronic morbidity mortality. Lactate, once considered as metabolic byproduct, has emerged key regulator of cellular reprogramming through lactylation, novel post-translational modification (PTM) that dynamically couples flux to chromatin remodeling. Lactylation exerts dual regulatory roles signaling molecule via GPR81/GPR4-mediated pathways substrate for the covalent histones enzymes. Pathologically, hyperlactatemia suppresses mitochondrial biogenesis, driving cardiomyopathy epigenetic silencing oxidative metabolism genes. Conversely, exercise-induced lactate surges transiently enhance insulin sensitivity AMPK/PGC-1α/GLUT4 signaling, resolve inflammation GPR81-mediated M2 macrophage polarization, restore function lactylation-dependent pathways. This review delineates lactylation spatiotemporal rheostat: dysregulation perpetuates disorders, whereas acute exercise-mediated remodels transcriptional networks homeostasis. Future research should integrate multiomics clarify lactylation’s dynamics, tissue-specific thresholds, metabolism–immunity interactions, metabolic–epigenetic crosstalk precision management diseases.
Language: Английский
Citations
0
Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Nov. 18, 2024
Background The serum lactate/albumin ratio (LAR) is commonly employed for monitoring and evaluating the prognosis of critically ill patients. Both elevated lactate levels decreased albumin may reflect body's stress response inflammatory reaction. Coronary heart disease (CHD), with common complications including myocardial infarction, arrhythmia, failure, one leading causes global death. Therefore, it crucial to explore biomarkers that can predict mortality CHD Methods This a retrospective study in which data from MIMIC-IV database. Our assessed association between LAR value within 28 days admission total 1,902 patients Beth Israel Deaconess Medical Center. Results results demonstrated significant increase 28-day among individuals higher values. Multivariate analysis by Cox proportional hazard model revealed an incremental rise across each quartile value. Furthermore, restricted cubic spline (RCS) regression further values were associated increased And subgroup confirmed level could serve as independent predictor Conclusions be important risk CHD, associate rate.
Language: Английский
Citations
1
Experimental Cell Research, Journal Year: 2024, Volume and Issue: 444(2), P. 114392 - 114392
Published: Dec. 20, 2024
Language: Английский
Citations
0