Don’t Be Surprised When These Surprise You: Some Infrequently Studied Sphingoid Bases, Metabolites, and Factors That Should Be Kept in Mind During Sphingolipidomic Studies
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 650 - 650
Published: Jan. 14, 2025
Sphingolipidomic
mass
spectrometry
has
provided
valuable
information-and
surprises-about
sphingolipid
structures,
metabolism,
and
functions
in
normal
biological
processes
disease.
Nonetheless,
many
noteworthy
compounds
are
not
routinely
determined,
such
as
the
following:
most
of
sphingoid
bases
that
mammals
biosynthesize
de
novo
other
than
sphingosine
(and
sometimes
sphinganine)
or
acquire
from
exogenous
sources;
infrequently
considered
metabolites
bases,
N-(methyl)n-derivatives;
"ceramides"
common
N-acylsphingosines;
complex
sphingolipids
sphingomyelins
simple
glycosphingolipids,
including
glucosyl-
galactosylceramides,
which
usually
reported
"monohexosylceramides".
These
subspecies
discussed,
well
some
circumstances
when
they
likely
to
be
seen
(or
present
missed)
due
experimental
conditions
can
influence
uptake
diet
microbiome,
artifacts
produced
during
extraction
analysis.
If
these
factors
kept
mind
design
interpretation
lipidomic
studies,
investigators
surprised
by
how
often
appear
thereby
advance
knowledge
about
them.
Language: Английский
Editorial: Novel insights into the modulation of protein function by lipids and membrane organization
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: April 24, 2025
Language: Английский
How has the evolution of our understanding of the compartmentalization of sphingolipid biosynthesis over the past 30 years altered our view of the evolution of the pathway?
Current topics in membranes,
Journal Year:
2024,
Volume and Issue:
unknown, P. 51 - 73
Published: Jan. 1, 2024
Language: Английский
Glycosphingolipids: From metabolism to chemoenzymatic total synthesis
Mitra K. F. Bonab,
No information about this author
Zhongwu Guo,
No information about this author
Qingjiang Li
No information about this author
et al.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(33), P. 6665 - 6683
Published: Jan. 1, 2024
GSLs
are
the
major
glycolipids
in
vertebrates
and
mediate
many
key
biological
processes
from
intercellular
recognition
to
Language: Английский
Fine-tuned protein-lipid interactions in biological membranes: exploration and implications of the ORMDL-ceramide negative feedback loop in the endoplasmic reticulum
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Aug. 7, 2024
Biological
membranes
consist
of
a
lipid
bilayer
in
which
integral
membrane
proteins
are
embedded.
Based
on
the
compositional
complexity
species
found
membranes,
and
their
specific
selective
interactions
with
proteins,
we
recently
suggested
that
bilayers
can
be
best
described
as
"finely-tuned
molecular
machines."
We
now
discuss
one
such
set
lipid-protein
by
describing
negative
feedback
mechanism
operating
Language: Английский
Why do we study sphingolipids?
Pflügers Archiv - European Journal of Physiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 19, 2024
Language: Английский
An anomalous abundance of tryptophan residues in ceramide synthases based on analysis of all membrane proteins in the Swiss-Prot database
Journal of Biological Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 108053 - 108053
Published: Dec. 1, 2024
Language: Английский