Microbial Pathogenesis,
Journal Year:
2024,
Volume and Issue:
197, P. 107091 - 107091
Published: Oct. 30, 2024
The
discoveries
of
the
oncomicrobiome
(intratumoral
microbiome)
and
oncomicrobiota
microbiota)
represent
significant
advances
in
tumor
research
have
rapidly
become
key
interest
to
field.
Within
tumors,
microorganisms
such
as
bacteria,
fungi,
viruses,
archaea
form
are
primarily
found
within
cells,
immunocytes,
intercellular
matrix.
exhibits
marked
heterogeneity
is
associated
with
initiation,
progression,
metastasis,
treatment
response.
Interactions
between
immune
system
can
modulate
host
antitumor
immunity,
influencing
efficacy
immunotherapies.
Oncomicrobiome
also
faces
numerous
challenges,
including
overcoming
methodological
issues
low
target
abundance,
susceptibility
contamination,
biases
sample
handling
analysis
methods
across
different
studies.
Furthermore,
studies
may
be
confounded
by
baseline
differences
microbiomes
among
populations
driven
both
environmental
genetic
factors.
Most
date
revealed
associations
but
very
few
established
mechanistic
links
two.
This
review
introduces
relevant
concepts,
detection
methods,
sources,
characteristics
oncomicrobiome.
We
then
describe
composition
common
tumors
its
role
shaping
microenvironment.
discuss
current
problems
challenges
overcome
this
progressing
Life Sciences,
Journal Year:
2023,
Volume and Issue:
332, P. 122126 - 122126
Published: Sept. 27, 2023
Small
extracellular
vesicles
(sEVs)
are
a
type
of
membranous
that
can
be
released
by
cells
into
the
space.
The
relationship
between
sEVs
and
non-coding
RNAs
(ncRNAs)
is
highly
intricate
interdependent.
This
symbiotic
plays
pivotal
role
in
facilitating
intercellular
communication
holds
profound
implications
for
myriad
biological
processes.
concept
their
ncRNA
cargo
as
"Trojan
Horse"
highlights
remarkable
capacity
to
traverse
barriers
surreptitiously
deliver
target
cells,
evading
detection
host-immune
system.
Accumulating
evidence
suggests
may
harnessed
carriers
ferry
therapeutic
ncRNAs
capable
selectively
silencing
disease-driving
genes,
particularly
conditions
such
cancer.
approach
presents
several
advantages
over
conventional
drug
delivery
methods,
opening
up
new
possibilities
targeted
therapy
improved
treatment
outcomes.
However,
utilization
agents
raises
valid
concerns
regarding
possibility
unforeseen
consequences
unintended
impacts
emerge
from
application.
It
important
consider
fundamental
attributes
ncRNAs,
including
an
in-depth
analysis
practical
clinical
potentials
exosomes,
serving
representative
model
encapsulating
ncRNAs.
PROTEOMICS,
Journal Year:
2023,
Volume and Issue:
24(11)
Published: Nov. 30, 2023
Abstract
Advances
in
technologies
to
isolate
extracellular
vesicles
(EVs)
and
detect/quantify
their
cargo
underpin
the
novel
potential
of
these
circulating
particles
as
a
liquid
biopsy
understand
physiology
disease.
One
organ
particular
interest
terms
utilizing
EVs
is
liver.
The
extent
which
originating
from
liver
reflect
functional
status
this
remains
unknown.
This
an
important
knowledge
gap
that
underpins
utility
derived
biopsy.
primary
objective
study
was
characterize
proteomic
profile
isolated
space
tissue
(LEV)
compare
paired
(LH).
LCMS
analyses
detected
2892
proteins
LEV
2673
LH.
Of
LH,
1547
(58%)
were
also
LEV.
Bioinformatic
demonstrated
comparable
representation
biological
functions
cellular
compartments.
Although,
enriched
membrane
associated
observed
LEV,
while
nuclear
depleted
These
data
support
use
for
organ.
Extracellular Vesicles and Circulating Nucleic Acids,
Journal Year:
2024,
Volume and Issue:
5(2), P. 180 - 200
Published: May 9, 2024
Pancreatic
cancer
is
a
highly
lethal
and
metastatic
malignancy,
mainly
because
it
often
remains
undetected
until
advanced
stages
due
to
the
limitations
of
current
diagnostic
methods,
rendering
currently
available
therapies
ineffective.
Therefore,
imperative
identify
useful
biomarkers
for
early
diagnosis
new
therapeutic
targets
pancreatic
cancer.
Recently,
extracellular
vesicles
have
emerged
as
promising
prognosis
Given
their
presence
in
various
bodily
fluids,
offer
non-invasive
approach
through
liquid
biopsy
detect
monitor
progression.
In
this
review,
we
comprehensively
examine
multifaceted
roles
progression
cancer,
while
also
exploring
potential
diagnostic,
prognostic,
context
Microbial Pathogenesis,
Journal Year:
2024,
Volume and Issue:
197, P. 107091 - 107091
Published: Oct. 30, 2024
The
discoveries
of
the
oncomicrobiome
(intratumoral
microbiome)
and
oncomicrobiota
microbiota)
represent
significant
advances
in
tumor
research
have
rapidly
become
key
interest
to
field.
Within
tumors,
microorganisms
such
as
bacteria,
fungi,
viruses,
archaea
form
are
primarily
found
within
cells,
immunocytes,
intercellular
matrix.
exhibits
marked
heterogeneity
is
associated
with
initiation,
progression,
metastasis,
treatment
response.
Interactions
between
immune
system
can
modulate
host
antitumor
immunity,
influencing
efficacy
immunotherapies.
Oncomicrobiome
also
faces
numerous
challenges,
including
overcoming
methodological
issues
low
target
abundance,
susceptibility
contamination,
biases
sample
handling
analysis
methods
across
different
studies.
Furthermore,
studies
may
be
confounded
by
baseline
differences
microbiomes
among
populations
driven
both
environmental
genetic
factors.
Most
date
revealed
associations
but
very
few
established
mechanistic
links
two.
This
review
introduces
relevant
concepts,
detection
methods,
sources,
characteristics
oncomicrobiome.
We
then
describe
composition
common
tumors
its
role
shaping
microenvironment.
discuss
current
problems
challenges
overcome
this
progressing
