Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 14(3), P. 1472 - 1476
Published: Dec. 4, 2023
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: March 12, 2024
The breast cancer tumor microenvironment (TME) is dynamic, with various immune and non-immune cells interacting to regulate progression anti-tumor immunity. It now evident that the within TME significantly contribute resistance conventional newly developed therapies. Both in play critical roles onset, uncontrolled proliferation, metastasis, evasion, Consequently, molecular cellular components of have emerged as promising therapeutic targets for developing novel treatments. primarily comprises cells, stromal vasculature, infiltrating cells. Currently, numerous clinical trials targeting specific are underway. However, complexity its impact on evasion immunity necessitate further research develop improved multifaceted nature arises from their phenotypic functional plasticity, which endows them both pro during progression. In this review, we discuss current understanding recent advances anti-tumoral functions implications safe effective therapies control progress.
Language: Английский
Citations
18
Journal of Experimental & Clinical Cancer Research, Journal Year: 2023, Volume and Issue: 42(1)
Published: March 10, 2023
Metabolic reprogramming is one of the hallmarks cancer. As nutrients are scarce in tumor microenvironment (TME), cells adopt multiple metabolic adaptations to meet their growth requirements. not only present cells, but exosomal cargos mediates intercellular communication between and non-tumor TME, inducing remodeling create an outpost microvascular enrichment immune escape. Here, we highlight composition characteristics meanwhile summarize components corresponding sorting mode. Functionally, these cargos-mediated improves "soil" for metastasis. Moreover, discuss abnormal metabolism targeted by its potential antitumor therapy. In conclusion, this review updates current role TME enriches future application scenarios exosomes.
Language: Английский
Citations
41
Biochimie, Journal Year: 2023, Volume and Issue: 219, P. 118 - 129
Published: Nov. 21, 2023
Breast cancer is the most prevalent in women. Metabolic abnormalities, particularly increased lipid synthesis and uptake, impact onset progression of disease. However, influence metabolism breast varies according to disease stage patient's hormone status. In postmenopausal patients, obesity associated with a higher risk poor prognosis luminal tumors, while premenopausal individuals, it correlated BRCA mutated tumors. fact, tumor's profile may be used distinguish between HER2+, BRCA-mutated Moreover, drug resistance was fatty acid alterations membrane composition, impacting its fluidity spatial subdomains such as rafts. Here, we discuss subtype-specific found potentiality modulation clinical setting.
Language: Английский
Citations
13
BMC Bioinformatics, Journal Year: 2025, Volume and Issue: 26(1)
Published: Jan. 21, 2025
Language: Английский
Citations
0
Cancer Biology & Therapy, Journal Year: 2025, Volume and Issue: 26(1)
Published: May 12, 2025
The epidemic of obesity is a growing concern and one the major risk factors for several chronic diseases, including types cancers. correlation breast cancer with has been extensively studied involves an interplay hormonal, metabolic, genetic explored in this review. Inflammation hormone dysregulation play important role promoting protumorigenic environment through adipose tissue, which involved energy storage functions as endocrine organ. As result, various cytokines, primarily proinflammatory nature, are released, resulting low-grade inflammation tumor growth. Additionally, obese conditions also induce imbalances hormones, particularly estrogen insulin, both drive carcinogenesis. Genetic components such single nucleotide polymorphisms critical roles modulating between cancer. This review provides comprehensive overview mechanisms underlying incidence progression.
Language: Английский
Citations
0
Journal of Breast Cancer, Journal Year: 2025, Volume and Issue: 28
Published: Jan. 1, 2025
Language: Английский
Citations
0
Cellular and Molecular Life Sciences, Journal Year: 2023, Volume and Issue: 80(9)
Published: Aug. 10, 2023
Abstract Breast cancer (BC) is the most frequently diagnosed and one of major causes death. Despite enormous progress in its management, both from therapeutic early diagnosis viewpoints, still around 700,000 patients succumb to disease each year, worldwide. Late recurrency problem BC, with many developing distant metastases several years after successful eradication primary tumor. This linked phenomenon metastatic dormancy, a mysterious trait natural history other types cancer, by which cells remain dormant for long periods time before becoming reactivated initiate clinical disease. In recent years, it has become clear that cancers are best understood if studied as ecosystems impact non-cancer-cell-autonomous events—dependent on complex interaction between environment, local systemic—plays paramount role, probably significant cell-autonomous alterations occurring cell. adopting this perspective, metabolic vision ecosystem bound improve our understanding across space time. pathways coopted into ecosystem, serve anabolic energy demands cancer. Their study shedding new light critical aspect BC dissemination, related dormancy fostering application knowledge development therapies.
Language: Английский
Citations
7
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Jan. 18, 2024
Abstract Adipocytes play a significant role in breast cancer due to the unique histological structure of breast. These have not only been detected adjacent cells but they also implicated development. obese individuals and tumor microenvironment (TME) common feature, that is, hypoxia. The increased expression hypoxia-inducible factor (HIF)-1α is known alter metabolism functions adipocytes. In this study, we described mechanism linking hypoxia-sensing pathway manifested by HIF adipocytes discussed underlying hypoxic development from perspective metabolic remodeling. processes pathways could be promising target therapy.
Language: Английский
Citations
2
Nutrients, Journal Year: 2024, Volume and Issue: 16(19), P. 3243 - 3243
Published: Sept. 25, 2024
Breast cancer (BC) represents the most prevalent in women at any age after puberty. From a pathogenetic prospective, despite wide array of risk factors being identified thus far, poor metabolic health is emerging as putative factor for BC. In particular, type 2 diabetes mellitus (T2DM) provides perfect example bridging gap between and BC risk. Indeed, T2DM preceded by status hyperinsulinemia characterised hyperglycaemia, with both representing potential contributors to onset progression. Additionally, aberrant secretome dysfunctional, hypertrophic adipocytes, typical obesity, pro-inflammatory mediators, shared this review, we provide an overview on effects hyperglycaemia hyperinsulinemia, hallmarks mellitus, breast risk, progression, treatment prognosis. Furthermore, dissect role adipose-tissue-secreted adipokines additional players pathogenesis Finally, focus microalgae novel superfood source nutraceuticals able mitigate improving targeting cellular pathways, which are disrupted context obesity.
Language: Английский
Citations
2
Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(44), P. 10738 - 10746
Published: Jan. 1, 2023
The NIR-II fluorescent probe Trastuzumab-800CW was used for targeting of HER-2-positive breast cancer tumors and systematically compared with Trastuzumab-ICG.
Language: Английский
Citations
5