Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 92, P. 105349 - 105349
Published: Jan. 6, 2024
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: 18(29), P. 19232 - 19246
Published: July 12, 2024
Despite the superior efficacy of radiotherapy in esophageal squamous cell carcinoma (ESCC), radioresistance by cancer stem cells (CSCs) leads to recurrence, metastasis, and treatment failure. Therefore, it is necessary develop CSC-based therapies enhance radiotherapy. miR-339-5p (miR339) involved division DNA damage checkpoint signaling pathways based on ESCC cohort. miR339 inhibited stemness enhanced radiation-induced targeting USP8, suggesting that acts as a potential CSC regulator radiosensitizer. Considering limited circulating periods poor tumor-targeting ability miRNA, multifunctional nanoplatform bismuth sulfide nanoflower (Bi@PP) developed efficiently deliver improve radioresistance. Intriguingly, Bi@PP encapsulates more owing their flower-shaped structure, delivering than 1000-fold into cells, free alone. Besides being used carrier, advantageous for dynamically monitoring distribution delivered vivo while simultaneously inhibiting tumor growth. Additionally, Bi@PP/miR339 can significantly patient-derived xenograft models. This platform, incorporating higher miRNA loading capacity, pH responsiveness, hypoxia relief, CT imaging, provides another method promote radiosensitivity optimize treatment.
Language: Английский
Citations
8
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: July 18, 2024
Graphical Abstract Created using Biorender.com .
Language: Английский
Citations
7
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10910 - 10910
Published: June 30, 2023
Cancer remains a leading cause of death globally, and its complexity poses significant challenge to effective treatment. stem cells their markers have become key players in tumor growth progression. CD133, marker various cancer types, is an active research area as potential therapeutic target. This article explores the role CD133 treatment, beginning with overview statistics explanation markers. The rise discussed, including structure, functions, occurrence different types. Furthermore, covers target, focusing on gene therapy, immunotherapy, approaches affect expression. Nanoparticles such gold nanoparticles nanoliposomes are also discussed context CD133-targeted therapy. In conclusion, promising target for As this progresses, it hoped that therapies will offer new treatment options patients future.
Language: Английский
Citations
14
Cancer Letters, Journal Year: 2024, Volume and Issue: 597, P. 217068 - 217068
Published: June 18, 2024
With the widespread use of anti-androgen therapy, such as abiraterone and enzalutamide, incidence neuroendocrine prostate cancer (NEPC) is increasing. NEPC a lethal form (PCa), with median overall survival less than one year after diagnosis. In addition to common bone metastases seen in PCa, exhibits characteristics visceral metastases, notably liver metastasis, which serves an indicator poor prognosis clinically. Key factors driving plasticity PCa have been identified, yet underlying mechanism behind metastasis remains unclear. this study, we identified PROX1 driver responsible for promoting metastases. Mechanistically, therapy alleviates transcriptional inhibition PROX1. Subsequently, elevated levels drive both liver-specific reprogramming, Moreover, induced by depend on reprogrammed lipid metabolism, disruption that effectively reduces formation
Language: Английский
Citations
6
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116408 - 116408
Published: March 12, 2024
Malignant tumors constitute a significant category of diseases posing severe threat to human survival and health, thereby representing one the most challenging pressing issues in field biomedical research. Due their malignant nature, which is characterized by high potential for metastasis, rapid dissemination, frequent recurrence, prevailing approach clinical oncology involves comprehensive treatment strategy that combines surgery with radiotherapy, chemotherapy, targeted drug therapies, other interventions. Treatment resistance remains major obstacle management tumors, serving as primary cause failure integrated tumor therapies critical factor contributing patient relapse mortality. The Minichromosome Maintenance (MCM) protein family comprises functional proteins closely associated development therapy.The influence MCMs manifests through various pathways, encompassing modulation DNA replication, cell cycle regulation, damage repair mechanisms. Consequently, this leads an enhanced tolerance cells drugs, radiation. review explores specific roles MCM cancer strategies. Its objective enhance our comprehension mechanisms therapy, presenting novel targets research aimed at overcoming treatment. This bears substantial relevance.
Language: Английский
Citations
5
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117486 - 117486
Published: Sept. 24, 2024
Language: Английский
Citations
4
Rare Metals, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
Language: Английский
Citations
0
International Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: 55(3)
Published: Jan. 23, 2025
Cancer stem cells (CSCs) represent a small, yet pivotal subpopulation of tumor that play significant roles in initiation, progression and therapeutic resistance. Circular RNAs (circRNAs) are distinct class characterized by their closed‑loop structures, lacking 5' to 3'ends. There is growing evidence circRNAs integral the development regulation CSCs. Aberrant expression CSCs can contribute oncogenic properties drug Specifically, modulate CSC behavior via key signaling pathways, thereby promoting self‑renewal maintenance, as well progression. This review summarizes latest research on functional regulatory mechanisms discusses potential applications challenges targeting Understanding intricate interactions between may lead novel strategies effectively combat treatment resistance improve patient outcomes.
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 20, 2025
SOX2 is one of the members SOX transcription factor family, which believed to be an important that plays a role in embryonic development, maintenance stem cells, cancer progression, and resistance treatment. There increasing evidence suggesting crucial for initiation, invasion, metastasis, treatment prostate cancer, therefore understanding mechanism can provide better targets cancer. This article reviews structural domains, normal physiological functions, progression SOX2, providing potential
Language: Английский
Citations
0
Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 5, 2025
Compared to most tumors that are more glycolytic, primary prostate cancer is less glycolytic but dependent on TCA cycle coupled with OXPHOS for its energy demand. This unique metabolic energetic feature attributed activation of mitochondrial m-aconitase in caused by decreased cellular Zn level. Evidence suggests a small subpopulation cells within tumors, designated as stem (PCSCs), play significant roles advanced progression. However, their energetics status still poorly understood. Nuclear receptor ERRα (ESRRA) key regulator metabolism. Previous studies characterize exhibits an upregulation and can perform multiple oncogenic functions. Here, we demonstrate novel role the control stemness metabolism PCSCs via mechanism combined transrepression transporter ZIP1 reducing intracellular uptake transactivation ACO2 (m-aconitase) completion cycle. Results also showed restoration accumulation treatment ionophore Clioquinol could significantly suppress both vitro growth vivo tumorigenicity, implicating enhanced be potential therapeutic approach targeting cancer.
Language: Английский
Citations
0