CyTA - Journal of Food, Journal Year: 2025, Volume and Issue: 23(1)
Published: June 2, 2025
Language: Английский
Cancers, Journal Year: 2024, Volume and Issue: 16(12), P. 2262 - 2262
Published: June 18, 2024
Melanoma, originating through malignant transformation of melanin-producing melanocytes, is a formidable malignancy, characterized by local invasiveness, recurrence, early metastasis, resistance to therapy, and high mortality rate. This review discusses etiologic risk factors for melanoma, diagnostic prognostic tools, including recent advances in molecular biology, omics, bioinformatics, provides an overview its therapy. Since the incidence melanoma rising remains unacceptably high, we discuss inherent properties, melanogenesis, that make this disease resilient treatment propose use AI solve above complex multidimensional problems. We provide on vitamin D anticancerogenic report field can solutions prevention and/or therapy melanoma. Experimental papers clinicopathological studies role status signaling pathways initiated active metabolites prognosis are reviewed. conclude signaling, defined specific nuclear receptors selective activation hydroxyderivatives, benefit new or existing therapeutic approaches. target with computational biology tools solution problem.
Language: Английский
Citations
22
Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1), P. 100004 - 100004
Published: Jan. 30, 2024
Natural products have attracted wide attention in the cosmetics market due to their safety and high efficiency. As a highly active substance nature, natural polysaccharides been reported recent years various cosmetic activities such as moisturizing, whitening, anti-aging repairing skin, are becoming hot research topic industry. At present, mechanism of polysaccharide exerting activity has widely studied, but relationship between polysaccharide's chemical structure not effectively analyzed, which leads limitation development. In this review, skin repair was introduced. The potential summarized by analyzing influence physical properties polysaccharides, extraction method, molecular weight, monosaccharide composition, functional group structural modification, etc., laid foundation for analysis improved its value.
Language: Английский
Citations
21
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129458 - 129458
Published: Jan. 21, 2024
Language: Английский
Citations
12
Cosmetics, Journal Year: 2024, Volume and Issue: 11(2), P. 37 - 37
Published: March 1, 2024
Vitamin D is a natural photoproduct that has many beneficial effects on different organs, including skin. Active forms of vitamin and its derivatives exert biological skin cells, thus maintaining homeostasis. In keratinocytes, they inhibit proliferation stimulate differentiation, have anti-inflammatory properties, act as antioxidants, DNA damage repair after ultraviolet (UV) exposure. melanocytes, also cell proliferation, apoptosis antioxidants. fibroblasts, affect fibrotic processes collagen production, promote wound healing regeneration. On the other hand, cells ability to activate directly. These activities, along with projected topical application derivatives, are promising for care photo protection can be used in prevention or possible reversal aging.
Language: Английский
Citations
11
Cell Biochemistry and Function, Journal Year: 2025, Volume and Issue: 43(2)
Published: Jan. 27, 2025
ABSTRACT The aryl hydrocarbon receptor (AhR), a ligand‐activated transcription factor, is extensively expressed in diverse human organs and plays pivotal role mediating the onset, progression, severity of numerous diseases. Recent research has explored substantial impact AhR on skin homeostasis related pathologies. As multi‐layered organ, comprises multiple cell populations that express AhR. In this review, we introduce various cells its barrier function. Furthermore, explore involvement development diseases, highlighting potential as therapeutic target for disorders. By targeting AhR, may open new avenues novel efficient disease treatments.
Language: Английский
Citations
1
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 224 - 224
Published: Feb. 7, 2025
Background/Objectives: Voglibose, an α-glucosidase inhibitor commonly prescribed to manage postprandial hyperglycemia in diabetes mellitus, demonstrates potential for repurposing as anti-melanogenic agent. This study aims explore the inhibitory effects of voglibose on melanogenesis and elucidate its molecular mechanisms, highlighting possible applications treating hyperpigmentation disorders. Methods: The were investigated using B16F10 melanoma cells. Cell viability, melanin content, tyrosinase activity assessed following treatment. Western blot analysis was performed examine changes melanogenic proteins transcription factors. role signaling pathways, including PKA/CREB, MAPK, PI3K/AKT, GSK3β/β-Catenin, analyzed. Primary human skin irritation tests conducted evaluate topical safety voglibose. Results: Voglibose significantly reduced synthesis cells a dose-dependent manner. revealed decreased expression MITF, TRP-1, TRP-2, indicating inhibition melanogenesis. modulated key suppression AKT activation, while restoring GSK3β inhibit β-catenin stabilization. Human confirmed voglibose’s application, showing no adverse reactions at 50 100 μM concentrations. Conclusions: properties through modulation multiple pathways biosynthesis. Its profile efficacy suggest repurposed drug managing advancing cosmeceutical applications.
Language: Английский
Citations
1
Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 788 - 788
Published: Feb. 8, 2025
Increasing attention is being focused on skin health currently, especially the excessive deposition of melanin in skin. Tyrosinase, rate-limiting enzyme biosynthesis, a crucial synthesis. However, existing tyrosinase inhibitors pose some degree toxicity to humans. Therefore, development more efficient and low-toxicity urgently needed. This review briefly depicts biosynthesis process crystal structure catalytic mechanism tyrosinase. The latest research progress regarding small-molecule also reviewed. Moreover, structure-function relationships are analyzed summarized. expected provide new scientific insights enable researchers explore safer potent inhibitors.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6199 - 6199
Published: June 4, 2024
The skin–brain axis has been suggested to play a role in several pathophysiological conditions, including opioid addiction, Parkinson’s disease and many others. Recent evidence suggests that pathways regulating skin pigmentation may directly indirectly regulate behaviour. Conversely, CNS-driven neural hormonal responses have demonstrated pigmentation, e.g., under stress. Additionally, due the shared neuroectodermal origins of melanocytes neurons CNS, certain CNS diseases be linked pigmentation-related changes common regulators, MC1R variations. Furthermore, HPA analogue connects endocrine system, thereby allowing index possible abnormalities visibly. In this review, insight is provided into pigment production neuromelanin synthesis brain recent findings are summarised on how signalling skin, with particular focus interconnected central nervous system. Thus, review supply better understanding mechanism associations health disease.
Language: Английский
Citations
6
Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1320, P. 343026 - 343026
Published: July 26, 2024
Language: Английский
Citations
5
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 150, P. 107612 - 107612
Published: July 2, 2024
Language: Английский
Citations
4