Extra-axial inflammatory signal and its relationship to peripheral and central immunity in depression DOI Creative Commons
Brandi Eiff, Edward T. Bullmore, Menna R. Clatworthy

et al.

Brain, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Although both central and peripheral inflammation have been observed consistently in depression, the relationship between two remains obscure. Extra-axial immune cells may play a role mediating connection immunity. This study investigates potential roles of calvarial bone marrow parameningeal spaces interactions immunity depression. PET was used to measure regional TSPO expression skull parameninges as marker inflammatory activity. correlated with brain cytokine concentrations cohort enriched for heightened comprising 51 individuals depression 25 healthy controls. The findings reveal complex Facial parietal showed significant associations confluence sinuses also linked markers. Group-dependent elevations within occipital were found be significantly associated inflammation. Significant activity skull, parameninges, parenchyma periphery highlight venous pivotal sites interactions.

Language: Английский

Choroid plexus volume is increased in mood disorders and associates with circulating inflammatory cytokines DOI
B. Bravi, Elisa Melloni, Marco Paolini

et al.

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 116, P. 52 - 61

Published: Nov. 27, 2023

Language: Английский

Citations

17
Unraveling the Role of the Blood-Brain Barrier in the Pathophysiology of Depression: Recent Advances and Future Perspectives DOI

Shamili Mariya Varghese,

Shashikant Patel,

Amritasree Nandan

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(12), P. 10398 - 10447

Published: May 10, 2024

Language: Английский

Citations

6
Have (R)-[11C]PK11195 challengers fulfilled the promise? A scoping review of clinical TSPO PET studies DOI Creative Commons
Fabien Chauveau, Guillaume Becker, Hervé Boutin

et al.

European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2021, Volume and Issue: 49(1), P. 201 - 220

Published: Aug. 13, 2021

Abstract Purpose The prototypical TSPO radiotracer ( R )-[ 11 C]PK11195 has been used in humans for more than thirty years to visualize neuroinflammation several pathologies. Alternative radiotracers have developed improve signal-to-noise ratio and started be tested clinically 2008. Here we examined the scientific value of these “( challengers” clinical research determine if they could supersede C]PK11195. Methods A systematic MEDLINE (PubMed) search was performed (up end year 2020) extract publications reporting PET patients with identified pathologies, excluding studies healthy subjects methodological studies. Results Of 288 selected, 152 13 challengers, 142 Over last 20 years, number remained stable (6 ± 3 per year), but surpassed by total challenger 6 years. In total, 3914 underwent a scan, 47% (1851 patients) received 2 main challengers were [ C]PBR28 (24%—938 18 F]FEPPA (11%—429 patients). Only one-in-ten (11%—447) scans, among whom 40 (1%) scanned different radiotracers. Conclusions Generally, confirmed disease-specific initial findings. However, while their better seems particularly useful diseases moderate widespread neuroinflammation, most present an allelic-dependent (Ala147Thr polymorphism) binding genetic stratification is hindering implementation. As new insensitive human polymorphism, are about enter evaluation, propose this review regularly updated (living review).

Language: Английский

Citations

37
Blood-brain barrier dysfunction in bipolar disorder: Molecular mechanisms and clinical implications DOI Creative Commons
Ning Zhao, Natasha Topolski, Massimo Tusconi

et al.

Brain Behavior & Immunity - Health, Journal Year: 2022, Volume and Issue: 21, P. 100441 - 100441

Published: March 5, 2022

Bipolar disorder (BD) is a severe psychiatric affecting approximately 1–3% of the population and characterized by chronic recurrent course debilitating symptoms. An increasing focus has been directed to discover explain function Blood-Brain Barrier (BBB) integrity its association with number disorders; however, there limited research in role BBB BD. Multiple pathways may play crucial roles modulating BD, such as inflammation, insulin resistance, alterations neuronal plasticity. In turn, impairment hypothesized have significant clinical impact BD patients. Based on high prevalence medical comorbidities growing body evidence linking inflammatory neuroinflammatory mechanisms disorder, recent studies suggested that dysfunction key BD's pathophysiology. this comprehensive narrative review, we aim discuss investigating biological markers patients modulate integrity, their implications patients, targets for future development novel therapies.

Language: Английский

Citations

23
Butyrate emerges as a crucial effector of Zhi-Zi-Chi decoctions to ameliorate depression via multiple pathways of brain-gut axis DOI Creative Commons
Jialin Liu,

Yichao Fang,

Li-Xun Cui

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 149, P. 112861 - 112861

Published: March 23, 2022

Gut microbiota has emerged as a crucial target of gut-brain axis to influence depression. Zhi-Zi-Chi decoctions (ZZCD), classic oral formula in clinic, is widely applied depression treatment nowadays. However, the underlying mechanism antidepressant activity ZZCD remains unknown. A model chronic mild unpredictable stress (CUMS) was established rats based on results behavioral tests and hippocampal histomorphology. 16S rRNA sequencing analysis indicated that could increase short-chain fatty acid-producing anti-inflammatory bacteria reduce inflammatory tryptophan-metabolizing bacteria. Furthermore, reversed alterations BDNF, TNF-α, pro-inflammatory cytokines neurotransmitters gut, blood brain along brain-gut restored decrease butyrate cecal content caused by CUMS. Then, utilized validate its ameliorative effect pathological characteristics depressive rats. Taken together, these show exhibits through modulating gut facilitate production butyrate, which further regulate anti-inflammation, neurotransmitters, endocrine BDNF axis. Hence, this study fills gap antidepressive light multi-targets multi-levels platform eventually for research into other TCM efficacy.

Language: Английский

Citations

23
Multimodal assessment of brain fluid clearance is associated with amyloid-beta deposition in humans DOI
Liangdong Zhou, Tracy Butler, Xiuyuan Wang

et al.

Journal of Neuroradiology, Journal Year: 2023, Volume and Issue: 51(4), P. 101164 - 101164

Published: Oct. 30, 2023

Language: Английский

Citations

15
What can neuroimmunology teach us about the symptoms of long-COVID? DOI Creative Commons
Valeria Mondelli, Carmine M. Pariante

Oxford Open Immunology, Journal Year: 2021, Volume and Issue: 2(1)

Published: Jan. 1, 2021

Abstract Long-Coronavirus Disease (Long-COVID) is becoming increasingly recognized due to the persistence of symptoms such as profound fatigue, neurocognitive difficulties, muscle pains and weaknesses depression, which would last beyond 3–12 weeks following infection with SARS-CoV-2. These particular have been extensively observed studied in context previous psychoneuroimmunology research. In this short commentary, we discuss how neuroimmunology studies could help us better understand pathways behind development these prolonged symptoms. Various mechanisms, including viral neuroinvasion, glial cells activation, neurogenesis, oxidative stress shown explain other disorders. Previous findings represent helpful pointers for future research on long-COVID suggest potential management strategies patients suffering long-COVID.

Language: Английский

Citations

28
Association between serum copper, zinc, and selenium concentrations and depressive symptoms in the US adult population, NHANES (2011–2016) DOI Creative Commons

Dong Huang,

Shunkai Lai,

Shuming Zhong

et al.

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: July 11, 2023

Abstract Background Evidence suggests that alterations in serum trace element concentrations are closely associated with mental illness. However, ​studies on the relationship between copper, zinc, and selenium depressive symptoms limited controversial results. We aimed to investigate association of these elements US adults. Methods Data from National Health Nutrition Examination Survey (NHANES) (2011–2016) were used this cross-sectional study. The Patient Questionnaire-9 Items (PHQ-9) was employed assess symptoms. Multiple logistic regression performed determine Results A total 4552 adults included. Subjects had higher copper (123.88 ± 1.87) than those without (116.99 0.86) ( p < 0.001). In Model 2, weighted analysis showed second (Q2) quartile zinc (odds ratio [OR] = 1.534, 95% confident interval [CI]: 1.018 2.313) significantly an increased risk Subgroup revealed third (Q3) fourth (Q4) quartiles (Q3: OR 2.699, CI: 1.285 5.667; Q4: 2.490, 1.026 6.046) also positively obese individuals after controlling for all confounders. no significant observed. Conclusions Obese high concentrations, as well general low susceptible Nevertheless, causal mechanisms underlying relationships need be further explored.

Language: Английский

Citations

11
Brain ventricle and choroid plexus morphology as predictor of treatment response in major depression: Findings from the EMBARC study DOI Creative Commons
Harald Murck, Maurizio Fava, Cristina Cusin

et al.

Brain Behavior & Immunity - Health, Journal Year: 2023, Volume and Issue: 35, P. 100717 - 100717

Published: Dec. 20, 2023

Recent observations suggest a role of the volume cerebral ventricle volume, corpus callosum (CC) segment in particular that central-anterior part, and choroid plexus (CP) for treatment resistance major depressive disorder (MDD). An increased CP has been associated with inflammatory activity changes structure ventricles callosum. We attempt to replicate confirm these imaging markers are clinical outcome subjects from EMBARC study, as implied by recent pilot study. The study is placebo controlled randomized comparing sertraline vs. patients MDD identify biological therapy resistance. Association baseline volumes lateral (LVV), (CPV) segments CC response after 4 weeks was evaluated. 171 (61 male, 110 female) completed week assessments; gender age were taken into account this analyses. As previously reported, no effect observed, therefore characterized prognostic pooled population. Change depression severity identified ratio Hamilton-Depression rating scale 17 (HAMD-17) at divided HAMD-17 (HAMD-17 ratio). Volumes plexi positively correlated ratio, indication worse larger volumes, whereas negatively ratio. Responders (n = 54) had significantly smaller compared non-responders 117), mid-anterior confirming our previous findings. In an exploratory way associations between enlarged LVV CPV signs lipid dysregulation observed. conclusion, we confirmed ventricles, improvement may be indicators metabolic/inflammatory activity.

Language: Английский

Citations

11
A Test-Retest Study of Single- and Multi-Delay pCASL for Choroid Plexus Perfusion Imaging in Healthy Subjects Aged 19 to 87 Years DOI Creative Commons
Zixuan Liu, Qinyang Shou, Kay Jann

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121048 - 121048

Published: Jan. 1, 2025

Language: Английский

Citations

0