Stress and cancer: mechanisms, significance and future directions

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(12), P. 767 - 785

Published: Sept. 10, 2021

Language: Английский

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Colorectal Cancer: Epidemiology, Risk Factors, and Prevention

Cancers, Journal Year: 2024, Volume and Issue: 16(8), P. 1530 - 1530

Published: April 17, 2024

Colorectal cancer (CRC) is the third most common and second cause of mortality worldwide. There are disparities in epidemiology CRC across different populations, probably due to differences exposure lifestyle environmental factors related CRC. Prevention effective method for controlling Primary prevention includes determining avoiding modifiable risk (e.g., alcohol consumption, smoking, dietary factors) as well increasing protective physical activity, aspirin). Further studies, especially randomized, controlled trials, needed clarify association between incidence or factors. Detection removal precancerous colorectal lesions also an strategy Multiple factors, both at individual community levels patient preferences, availability screening modalities, costs, benefits, adverse events), should be taken into account designing implementing programs. Health policymakers consider best decision identifying starting age selection strategies target population. This review aims present updated evidence on epidemiology,

Language: Английский

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Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(6), P. 1680 - 1688

Published: May 13, 2024

Abstract Emotional distress (ED), commonly characterized by symptoms of depression and/or anxiety, is prevalent in patients with cancer. Preclinical studies suggest that ED can impair antitumor immune responses, but few clinical have explored its relationship response to checkpoint inhibitors (ICIs). Here we report results from cohort 1 the prospective observational STRESS-LUNG study, which investigated association between and efficacy first-line treatment ICIs advanced non-small-cell lung was assessed Patient Health Questionnaire-9 Generalized Anxiety Disorder 7-item scale. The study included 227 111 (48.9%) exhibiting who presented (Patient score ≥5) anxiety (Generalized at baseline. On primary endpoint analysis, baseline exhibited a significantly shorter median progression-free survival compared those without (7.9 months versus 15.5 months, hazard ratio 1.73, 95% confidence interval 1.23 2.43, P = 0.002). secondary associated lower objective rate (46.8% 62.1%, odds 0.54, 0.022), reduced 2-year overall 46.5% 64.9% (hazard for death 1.82, 1.12 2.97, 0.016) detriments quality life. exploratory analysis indicated group showed elevated blood cortisol levels, adverse outcomes. This suggests there an worse outcomes cancer treated ICIs, highlighting potential significance addressing management. ClinicalTrials.gov registration: NCT05477979 .

Language: Английский

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Xianlian Jiedu Decoction alleviates colorectal cancer by regulating metabolic profiles, intestinal microbiota and metabolites

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155385 - 155385

Published: Jan. 27, 2024

Language: Английский

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Stress and cancer: The mechanisms of immune dysregulation and management

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 5, 2022

Advances in the understanding of psychoneuroimmunology past decade have emphasized notion that stress and cancer are interlinked closely. Durable chronic accelerated tumorigenesis progression, which is unfavorable for clinical outcomes patients. Available evidence has provided unprecedented knowledge about role mechanisms carcinogenesis, most well-known one dysfunction hypothalamus-pituitary-adrenal (HPA) axis sympathetic nervous system (SNS). With abnormal activation neuroendocrine system, stress-related hormones contribute to increased oncogenes expression, exacerbated inflammation impaired immunologic function. In addition, accumulating studies demonstrated diverse interventions including pharmacological approaches, physical exercises psychological relaxation been administered assist mental disorders reduction life quality improvement this review, we systematically summarize connection stress-immune-cancer identified by animal studies, as well conclude effectiveness deficiencies existing management strategies.

Language: Английский

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Chronic stress in solid tumor development: from mechanisms to interventions

Journal of Biomedical Science, Journal Year: 2023, Volume and Issue: 30(1)

Published: Jan. 28, 2023

Chronic stress results in disturbances of body hormones through the neuroendocrine system. Cancer patients often experience recurrent anxiety and restlessness during disease progression treatment, which aggravates hinders treatment effects. Recent studies have shown that chronic stress-regulated systems secret to activate many signaling pathways related tumor development cells. The activated system acts not only on cells but also modulates survival metabolic changes surrounding non-cancerous Current clinical evidences suggest affects outcome cancer treatment. However, clinic, there is lack effective for patients. In this review, we discuss main mechanisms by regulates microenvironment, including functional regulation (stem cell-like properties, metastasis, angiogenesis, DNA damage accumulation, apoptotic resistance), reprogramming immune escape, peritumor neuromodulation. Based current framework stress, summarize pharmacological non-pharmacological therapeutic approaches provide some directions therapy.

Language: Английский

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Role of stress in the pathogenesis of cancer (Review)

International Journal of Oncology, Journal Year: 2023, Volume and Issue: 63(5)

Published: Sept. 11, 2023

Stress is a state of disrupted homeostasis, triggered by intrinsic or extrinsic factors, the stressors, which are counteracted various physiological and behavioural adaptive responses. has been linked to cancer development incidence for decades; however, epidemiological studies clinical trials have yielded contradictory results. The present review discusses effects stress on underlying mechanisms. Animal revealed clear link between progression, revealing molecular, cellular endocrine processes that implicated in these effects. Thus, hormones, their receptor systems intracellular molecular pathways mediate initiation, progression metastases. mechanisms linking can either be indirect, mediated changes microenvironment immune system dysregulation, direct, through binding neuroendocrine stress‑related signalling molecules cell receptors. affects numerous anti‑ pro‑cancer components, including host resistance metastasis, tumour retention and/or suppression. Chronic psychological elevation catecholamine levels may increase death resistance. On whole, incidence, with stressors playing crucial role. better than human ones, hormones influencing development, migration, invasion proliferation. Randomized controlled required further evaluate long‑term outcomes its management.

Language: Английский

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Neutrophil extracellular traps in cancer

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 15, 2024

Neutrophil extracellular traps (NETs), which consist of chromatin DNA studded with granule proteins, are released by neutrophils in response to both infectious and sterile inflammation. Beyond the canonical role defense against pathogens, extrusion NETs also contributes initiation, metastasis, therapeutic malignant diseases. Recently, have been implicated development responses various types tumors. Although extensive work regarding inflammation tumors has reported, a comprehensive summary how these web-like structures initiate propagate tumor progression under specific microenvironment is lacking. In this review, we demonstrate initiators related signaling pathways that trigger formation cancers. Additionally, review will outline current molecular mechanisms regulatory networks during dormant cancer cells awakening, circulating (CTCs) extravasation, metastatic recurrence cancer. This followed perspective on potential clinical as targets treatment local disease, including improvement efficacy existing therapies.

Language: Английский

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Chronic stress promotes colorectal cancer progression by enhancing glycolysis through β2-AR/CREB1 signal pathway

International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(7), P. 2006 - 2020

Published: Jan. 1, 2023

Colorectal cancer (CRC) is a common malignancy worldwide, and chronic stress has been considered as significant risk factor for CRC.However, the role of in CRC progression unclear.The present study showed that pre-exposure to facilitated tumor growth mice, epinephrine promoted cell proliferation vitro.Metabolomics analysis revealed reshaped metabolic pathways enhance glycolysis.Additional studies have shown enhanced expression levels glycolytic-associated enzymes, including GLUT1, HK2 PFKP.Mechanistically, activated β2-AR/PKA/CREB1 pathway, result, phosphorylated CREB1 transcriptional induced glycolytic enzymes expression.Furthermore, stress-induced could be reversed by administration glycolysis inhibitor 2-deoxyglucose (2-DG) β2-AR antagonist ICI118,551, respectively.Altogether, these findings define novel insights into epinephrine-mediated from point view energy metabolism reprogramming provide perspective on targeting potential approach stress-associated treatment.

Language: Английский

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Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis

Journal of Experimental & Clinical Cancer Research, Journal Year: 2023, Volume and Issue: 42(1)

Published: Sept. 29, 2023

Chronic stress promotes most hallmarks of cancer through impacting the malignant tissues, their microenvironment, immunity, lymphatic flow, etc. Existing studies mainly focused on roles stress-induced activation systemic sympathetic nervous system and other hormones, organ specificity chronic in shaping pre-metastatic niche remains largely unknown. This study investigated role remodeling lung breast cancer.Breast mouse models with were constructed by restraint or unpredictable stress. Expressions tyrosine hydroxylase, vesicular acetylcholine transporter (VAChT), EpCAM NETosis examined immunofluorescence confocal microscopy. mRNA protein levels choline acetyltransferase (ChAT), VAChT, peptidylarginine deiminase 4 detected qRT-PCR Western blotting, respectively. Immune cell subsets analyzed flow cytometry. Acetylcholine (ACh) chemokines ELISA multi chemokine array, ChAT tissues from patients was immunohistochemistry.Breast cancer-bearing mice suffered metastasized earlier showed more severe metastasis than did control group. ChAT+ epithelial cells increased significantly model undergone ACh especially CXCL2 culture supernatants profoundly increased. remodeled immune striking increase neutrophils, enhanced promoted NETotic neutrophils to capture cells. treatment resulted neutrophils. The expression higher that non-tumor pulmonary diseases.Chronic production recruits into lung, induces produce enhances Our findings demonstrate for first time induced derived plays a key cancer.

Language: Английский

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