Published: Jan. 1, 2024
Language: Английский
Cancer Letters, Journal Year: 2025, Volume and Issue: 611, P. 217451 - 217451
Published: Jan. 8, 2025
Language: Английский
Citations
2
International Journal of Oncology, Journal Year: 2023, Volume and Issue: 63(5)
Published: Sept. 11, 2023
Stress is a state of disrupted homeostasis, triggered by intrinsic or extrinsic factors, the stressors, which are counteracted various physiological and behavioural adaptive responses. has been linked to cancer development incidence for decades; however, epidemiological studies clinical trials have yielded contradictory results. The present review discusses effects stress on underlying mechanisms. Animal revealed clear link between progression, revealing molecular, cellular endocrine processes that implicated in these effects. Thus, hormones, their receptor systems intracellular molecular pathways mediate initiation, progression metastases. mechanisms linking can either be indirect, mediated changes microenvironment immune system dysregulation, direct, through binding neuroendocrine stress‑related signalling molecules cell receptors. affects numerous anti‑ pro‑cancer components, including host resistance metastasis, tumour retention and/or suppression. Chronic psychological elevation catecholamine levels may increase death resistance. On whole, incidence, with stressors playing crucial role. better than human ones, hormones influencing development, migration, invasion proliferation. Randomized controlled required further evaluate long‑term outcomes its management.
Language: Английский
Citations
29
Journal for ImmunoTherapy of Cancer, Journal Year: 2024, Volume and Issue: 12(9), P. e009318 - e009318
Published: Sept. 1, 2024
Pancreatic cancer is an incurable malignant disease with extremely poor prognosis and a complex tumor microenvironment. We sought to characterize the role of Annexin A1 (ANXA1) in pancreatic cancer, including its ability promote efferocytosis antitumor immune responses.
Language: Английский
Citations
6
MedComm, Journal Year: 2024, Volume and Issue: 5(11)
Published: Oct. 31, 2024
Abstract Cancer neuroscience is an emerging field that investigates the intricate relationship between nervous system and cancer, gaining increasing recognition for its importance. The central governs development of directly affects brain tumors, peripheral (PNS) shapes tumor microenvironment (TME) tumors. Both systems are crucial in cancer initiation progression, with recent studies revealing a more role PNS within TME. Tumors not only invade nerves but also persuade them through remodeling to further promote malignancy, creating bidirectional interaction cancers. Notably, immune cells contribute this communication, forming triangular influences protumor inflammation effectiveness immunotherapy. This review delves into mechanisms connecting focusing on how various cell types influence nerve‒tumor interactions, emphasizing clinical relevance nerve‒immune dynamics. By deepening our understanding interplay nerves, cells, has potential reshape biology insights, inspire innovative therapies, improve outcomes patients.
Language: Английский
Citations
6
PLoS Genetics, Journal Year: 2024, Volume and Issue: 20(4), P. e1011235 - e1011235
Published: April 22, 2024
Tumor-associated macrophages (TAM) subtypes have been shown to impact cancer prognosis and resistance immunotherapy. However, there is still a lack of systematic investigation into their molecular characteristics clinical relevance in different types. Single-cell RNA sequencing data from three tumor types were used cluster type macrophages. Functional analysis communication TAM subpopulations performed by Gene Ontology-Biological Process CellChat respectively. Differential expression characteristic genes was calculated using zscore as well edgeR Wilcoxon rank sum tests, subsequently gene enrichment anti-PD-1 the REACTOME database. We revealed heterogeneity TAM, identified eleven on prognosis. These expressed functions respectively, such being involved T cell activation, apoptosis differentiation, or regulating viral bioprocesses responses viruses. The SPP1 pathway critical mediator between subpopulations, epithelial cells. Macrophages with high resulted poorer survival. By vitro study, we showed mediated interactions clusters promoted tumor-promoting ability increased PDL1 stemness Inhibition attenuated N-cadherin β-catenin activation AKT STAT3 Additionally, found that several could decrease sensitivity therapy melanoma. signal macrophage subtypes. Some specific associated immunotherapy some
Language: Английский
Citations
5
Cancer Discovery, Journal Year: 2025, Volume and Issue: 15(1), P. 52 - 68
Published: Jan. 13, 2025
The exponential growth of the cancer neuroscience field has shown that host's immune, vascular, and nervous systems communicate with influence each other in tumor microenvironment, dictating malignant phenotype. Unraveling system's contributions toward this phenotype brings us closer to cures. In review, we summarize peripheral cancer. We highlight effects nerve recruitment innervation, neuro-immune axis, glial cell activity, neural regulation on development progression. also discuss harnessing control cancers as a potential therapeutic approach oncology. Significance: continued growing interest by scientific medical communities reflects rapidly accumulating interdisciplinary understanding modulation cells' functions malignancies. Understanding these regulatory can identify targets for intervention may already be clinically available indications. This great excitement hope patients worldwide.
Language: Английский
Citations
0
Healthcare, Journal Year: 2025, Volume and Issue: 13(6), P. 609 - 609
Published: March 11, 2025
Background: Cancer diagnosis causes a range of different emotions. It is also factor that feelings severe stress. Coping with stress individual and depends on the person’s nature, environment, support they receive. Aim: This study aimed to assess how women diagnosed breast cancer cope caused by disease. Methods: A total 111 participated in study. The questionnaires were distributed electronically using Google Forms online forums groups social media. survey consisted two parts: original questions Mini-COPE questionnaire. relationships between stress-coping strategies age, having children, marital status, life satisfaction tested. Mann–Whitney U test, Kruskal–Wallis Dunn’s post-hoc test Bonferroni correction used for analyses (p < 0.05). Results: Of surveyed women, 54.9% reported moment was most stressful. Feelings fear anxiety accompanied 30.5% 24.7% at time could not provide information about dominant seeking emotional (mean 2.12 ± 0.56) instrumental 2.06 0.48). Women older age group, married children likely adopt strategy turning religion. Conclusions: support. religion more often patients children.
Language: Английский
Citations
0
Annual Review of Biomedical Engineering, Journal Year: 2025, Volume and Issue: 27(1), P. 307 - 333
Published: May 1, 2025
Despite the advances in detection, diagnosis, and treatments, cancer remains a lethal disease, claiming lives of more than 600,000 people United States alone 2024. To accelerate development new therapeutic strategies with improved responses, significant efforts have been made to develop microfabricated vitro models tumor microenvironments (TMEs) that address limitations animal-based models. These incorporate several advanced tissue engineering techniques better reflect organ- patient-specific TMEs. Additionally, integrated next-generation single-cell omics technologies provide unprecedented insights into patient's cellular molecular heterogeneity complexity. This review provides an overview recent understanding outlines key TME elements can be captured enhance their physiological relevance. We highlight unique characteristics organs origin or sites dissemination.
Language: Английский
Citations
0
Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17
Published: Nov. 28, 2023
Chronic stress has a substantial influence on the tumor microenvironment (TME), leading to compromised effectiveness of anti-cancer therapies through diverse mechanisms. It disrupts vital functions immune cells that play critical role in anti-tumor immunity, such as inhibition dendritic (DCs) and lymphocytes, while simultaneously enhancing activity support growth, myeloid-derived suppressor tumor-associated macrophages. Furthermore, chronic exerts significant impact crucial mechanisms within TME, including angiogenesis, DNA repair, hypoxia, extracellular matrix deposition, metabolism. These alterations induced by stress, result from activation hypothalamic-pituitary-adrenal axis sympathetic nervous system, conjunction with epigenetic modifications. In conclusion, significantly influences TME impedes efficacy treatments, underscoring importance targeting pathways improve therapeutic results.
Language: Английский
Citations
9
Advanced Biology, Journal Year: 2024, Volume and Issue: 8(4)
Published: Jan. 14, 2024
Abstract Although cancer remains a challenging disease to treat, early detection and removal of primary tumors through surgery or chemotherapy/radiotherapy can offer hope for patients. The privilege paradigm in biology suggests that cell‐autonomous mechanisms play central role tumorigenesis. According this paradigm, these cellular are the focus prevention treatment cancers. However, point view does not present comprehensive theory initiation an effective therapeutic strategy. Having incomplete understanding etiology cancer, it is essential re‐examine previous assumptions about carcinogenesis develop new, practical theories account all available clinical experimental evidence. This will only help gain better disease, but also new avenues treatment. review provides evidence suggesting shift from mechanism systemic mechanisms, particularly immune system, involved formation.
Language: Английский
Citations
2