Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: Jan. 9, 2023

Abstract Mood disorders are associated with elevated inflammation, and the reduction of symptoms after multiple treatments is often accompanied by pro-inflammation restoration. A variety neuromodulation techniques that regulate regional brain activities have been used to treat refractory mood disorders. However, their efficacy varies from person lack reliable indicator. This review summarizes clinical animal studies on inflammation in neural circuits related anxiety depression evidence therapies neuroinflammation treatment neurological diseases. Neuromodulation therapies, including transcranial magnetic stimulation (TMS), electrical (TES), electroconvulsive therapy (ECT), photobiomodulation (PBM), ultrasound (TUS), deep (DBS), vagus nerve (VNS), all reported attenuate reduce release pro-inflammatory factors, which may be one reasons for improvement. provides a better understanding effective mechanism indicates inflammatory biomarkers serve as reference assessment pathological conditions options depression.

Language: Английский

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Amygdala Circuit Substrates for Stress Adaptation and Adversity

Biological Psychiatry, Journal Year: 2021, Volume and Issue: 89(9), P. 847 - 856

Published: Jan. 8, 2021

Brain systems that promote maintenance of homeostasis in the face stress have significant adaptive value. A growing body work across species demonstrates a critical role for amygdala promoting by regulating physiological and behavioral responses to stress. This review focuses on an emerging evidence has begun delineate contribution specific long-range circuits mediating effects After summarizing major anatomical features its connectivity other limbic structures, we discuss recent findings from rodents showing how causes structural functional remodeling neuronal outputs defined cortical subcortical target regions. We also consider some environmental genetic factors been found moderate responds relate preclinical literature current understanding pathophysiology treatment stress-related neuropsychiatric disorders. Future effort translate these clinics may help develop valuable tools prevention, diagnosis, diseases.

Language: Английский

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New Insights into the Pivotal Role of the Amygdala in Inflammation-Related Depression and Anxiety Disorder

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11076 - 11076

Published: Sept. 21, 2022

Depression and anxiety disorders are the two most prevalent psychiatric diseases that affect hundreds of millions individuals worldwide. Understanding etiology related mechanisms is great importance might yield new therapeutic strategies to treat these effectively. During past decades, a growing number studies have pointed out stress-induced inflammatory response in amygdala, kernel region for processing emotional stimuli, as potentially critical contributor pathophysiology depression disorders. In this review, we first summarized recent progress from both animal human toward understanding causal link between inflammation disorders, with particular emphasis on findings showing effect functional changes neurons at levels ranging molecular signaling, cellular function, synaptic plasticity, neural circuit behavior, well their contributions pathology inflammation-related Finally, concluded by discussing some difficulties surrounding current research propose issues worth future study field.

Language: Английский

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Astrocyte metabolism and signaling pathways in the CNS

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Sept. 4, 2023

Astrocytes comprise half of the cells in central nervous system and play a critical role maintaining metabolic homeostasis. Metabolic dysfunction astrocytes has been indicated as primary cause neurological diseases, such depression, Alzheimer’s disease, epilepsy. Although functionalities are well known, their relationship to disorders is poorly understood. The ways which regulate metabolism glucose, amino acids, lipids have all implicated diseases. Metabolism also exhibited significant influence on neuron functionality brain’s neuro-network. In this review, we focused processes present astrocytes, most notably glucose pathway, fatty acid amino-acid pathway. For metabolism, glycolysis pentose-phosphate oxidative phosphorylation followed oxidation, ketone body sphingolipid metabolism. summarized neurotransmitter serine kynurenine pathways. This review will provide an overview functional changes astrocyte overall perspective current treatment therapy for disorders.

Language: Английский

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The interaction between autophagy and neuroinflammation in major depressive disorder: From pathophysiology to therapeutic implications

Pharmacological Research, Journal Year: 2021, Volume and Issue: 168, P. 105586 - 105586

Published: April 1, 2021

Language: Английский

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Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: April 12, 2022

Depression is a common and serious mental disorder. Data on its pathogenesis remain unclear the options of drug treatments are limited. Here, we explored role pyroptosis, novel pro-inflammatory programmed cell death process, in depression as well anti-depression effects mechanisms salidroside (Sal), bioactive extract from Rhodiola rosea L. We established corticosterone (CORT)-induced or lipopolysaccharide (LPS)-induced mice vivo, CORT, nigericin (NLRP3 agonist)-induced PC12 cells vitro. Our findings demonstrated that Sal profoundly mediated CORT LPS-induced depressive behavior improved synaptic plasticity by upregulating expression brain-derived neurotrophic factor (BDNF) gene. The data showed upregulation proteins associated with NLRP3-mediated including NLRP3, cleaved Caspase-1, IL-1β, IL-18, GSDMD. molecular docking simulation predicted would interact P2X7 P2X7/NF-κB/NLRP3 signaling pathway. In addition, our pyroptosis was regulated Interestingly, shown to ameliorate via suppression rescued nigericin-induced cells. Besides, knock down NLRP3 gene siRNA markedly increased inhibitory proinflammatory responses. Taken together, plays crucial depression, ameliorates suppressing P2X7/NF-κB/NLRP3-mediated pyroptosis. Thus, study provides new insights into potential treatment for depression.

Language: Английский

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Astrocytes and major depression: The purinergic avenue

Neuropharmacology, Journal Year: 2022, Volume and Issue: 220, P. 109252 - 109252

Published: Sept. 16, 2022

Language: Английский

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An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 128, P. 110861 - 110861

Published: Sept. 9, 2023

There is a lot of evidence establishing that nervous system development related to the composition and functions gut microbiome. In addition, central (CNS) controls imbalance intestinal microbiota, constituting bidirectional communication system. At present, various gut-brain crosstalk routes have been described, including immune, endocrine neural circuits via vagal pathway. Several empirical data associated microbiota alterations (dysbiosis) with neuropsychiatric diseases, such as Alzheimer's disease, autism Parkinson's other psychological disorders, like anxiety depression. Fecal transplantation (FMT) therapy has shown can transfer behavioral features recipient animals, which provides strong establish causal-effect relationship. Interventions, based on prebiotics, probiotics or synbiotics, demonstrated an important influence neurological disorders by synthesis neuroactive compounds interact regulation inflammatory processes. Further research needed demonstrate dysbiosis psychiatric how microbiota-based interventions may be used potential therapeutic tools.

Language: Английский

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Melanin-like polydopamine nanoparticles mediating anti-inflammatory and rescuing synaptic loss for inflammatory depression therapy

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Feb. 10, 2023

Inflammatory depression is closely related to neuroinflammation. However, current anti-inflammatory drugs have low permeability cross blood-brain barrier with difficulties reaching the central nervous system provide therapeutic effectiveness. To overcome this limitation, nano-based drug delivery technology was used synthesize melanin-like polydopamine nanoparticles (PDA NPs) (~ 250 nm) which can barrier. Importantly, PDA NPs abundant phenolic hydroxyl groups function as excellent free radical scavengers attenuate cell damage caused by reactive oxygen species or acute inflammation. In vitro experiments revealed that exhibited antioxidative properties. Next, we aimed investigate effect of on inflammatory through intraperitoneal injection lipopolysaccharide-induced model in mice. significantly reversed depression-like behavior. also found reduce peripheral and inflammation induced LPS, showing alleviated splenomegaly, reduced serum cytokines, inhibited microglial activation restored synaptic loss. Various showed had good biocompatibility both vivo vitro. Our work suggested may be biocompatible nano-drugs treating but their clinical application requires further study.

Language: Английский

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Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex

Pharmacological Research, Journal Year: 2023, Volume and Issue: 191, P. 106717 - 106717

Published: March 21, 2023

Neuroinflammation is tightly associated with onset of depression. The nuclear receptor related 1 protein (Nurr1, also called Nr4a2), its roles in dopaminergic neurons well understood, which can alleviate inflammation. Nevertheless, potential effects Nr4a2 on neuroinflammation depression still remains unclear. Chronic lipopolysaccharides (LPS) stress induced depressive-behaviors were confirmed via behavioral tests. Differentially expressed genes detected by using RNA-sequencing. anterior cingulate cortex (ACC) tissues collected for biochemical experiments. Golgi-Cox staining and virus labeling used to evaluate the dendritic spines. We applied fluoxetine (FLX) amodiaquine dihydrochloride (AQ, a highly selective agonist Nr4a2) mice. Overexpression experiments performed injecting AAV-Nr4a2-EGFP into ACC. Chemogenetic activation CamkII hM3Dq virus. Mice treated LPS displayed depressive- anxiety-like behaviors. reduction FosB rescued pretreatment FLX or AQ. More importantly, LPS-induced behavior deficits mice alleviated treatment pharmacological expression Nr4a2. Meanwhile, enhancing level could improve spines loss neuron morphological changes microglia. ACC reversed behaviors caused administration. Activation robustly increase deficits. Our findings demonstrate that may regulate depressive-like alleviating impairment morphology function microglia chronic neuroinflammation.

Language: Английский

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