Metabolic Reprogramming of Astrocytes in Pathological Conditions: Implications for Neurodegenerative Diseases DOI Open Access
Corrado Calì,

Iva Cantando,

María Fernanda Veloz Castillo

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8922 - 8922

Published: Aug. 16, 2024

Astrocytes play a pivotal role in maintaining brain energy homeostasis, supporting neuronal function through glycolysis and lipid metabolism. This review explores the metabolic intricacies of astrocytes both physiological pathological conditions, highlighting their adaptive plasticity diverse functions. Under normal modulate synaptic activity, recycle neurotransmitters, maintain blood–brain barrier, ensuring balanced supply protection against oxidative stress. However, response to central nervous system pathologies such as neurotrauma, stroke, infections, neurodegenerative diseases like Alzheimer’s Huntington’s disease, undergo significant morphological, molecular, changes. Reactive upregulate fatty acid oxidation meet increased demands, which can be protective acute settings but may exacerbate chronic inflammation disease progression. emphasizes need for advanced genetic, tools further understand astrocyte heterogeneity reprogramming states.

Language: Английский

Glucose metabolism impairment in major depressive disorder DOI Creative Commons

Fanhao Meng,

Jing Wang, Long Wang

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 221, P. 111191 - 111191

Published: Jan. 7, 2025

Major depressive disorder (MDD) is a common mental with chronic tendencies that seriously affect regular work, life, and study. However, its exact pathogenesis remains unclear. Patients MDD experience systemic localized impairments in glucose metabolism throughout the disease course, disrupting various processes such as uptake, glycoprotein transport, glycolysis, tricarboxylic acid cycle (TCA), oxidative phosphorylation (OXPHOS). These may result from mechanisms including insulin resistance, hyperglycemia-induced damage, stress, astrocyte abnormalities, mitochondrial dysfunction, leading to insufficient energy supply, altered synaptic plasticity, neuronal cell death, functional structural damage reward networks. mechanical changes contribute of severely interfere prognosis. Herein, we summarized impairment pathophysiological patients MDD. In addition, briefly discussed potential pharmacological interventions for alleviate MDD, glucagon-like peptide-1 receptor agonists, metformin, topical insulin, liraglutide, pioglitazone, encourage development new therapeutics.

Language: Английский

Citations

1
The role of astrocyte metabolic reprogramming in ischemic stroke (Review) DOI Creative Commons
Weixin Chen, Tangyou Mao, Rui Ma

et al.

International Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: 55(3)

Published: Jan. 21, 2025

Ischemic stroke, a leading cause of disability and mortality worldwide, is characterized by the sudden loss blood flow in specific area brain. Intravenous thrombolysis with recombinant tissue plasminogen activator only approved pharmacological treatment for acute ischemic stroke; however, aforementioned has significant clinical limitations, thus there an urgent need development novel mechanisms therapeutic strategies stroke. Astrocytes, abundant versatile cells central nervous system, offer crucial support to neurons nutritionally, structurally physically. They also contribute blood‑brain barrier formation regulate neuronal extracellular ion concentrations. Accumulated evidence revealed involvement astrocytes regulation host neurotransmitter metabolism, immune response repair, different metabolic characteristics can process suggesting that targeted astrocyte reprogramming may prognosis In present review, current understanding multifaceted along its regulatory factors pathways, as well promote polarization balance, which hold promise immunometabolism‑targeted therapies were summarized.

Language: Английский

Citations

1
Astrocyte atrophy induced by L-PGDS/PGD2/Src signaling dysfunction in the central amygdala mediates postpartum depression DOI
Zhihao Sheng, Qidong Liu, Yujie Song

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 359, P. 241 - 252

Published: May 18, 2024

Language: Английский

Citations

5
Brain Metabolism in Health and Neurodegeneration: The Interplay Among Neurons and Astrocytes DOI Creative Commons
Polina Shichkova, Jay S. Coggan, Henry Markram

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(20), P. 1714 - 1714

Published: Oct. 17, 2024

The regulation of energy in the brain has garnered substantial attention recent years due to its significant implications various disorders and aging. brain's metabolism is a dynamic tightly regulated network that balances demand supply by engaging complementary molecular pathways. crosstalk among these pathways enables system switch preferred fuel source based on substrate availability, activity levels, cell state-related factors such as redox balance. Brain production relies multi-cellular cooperation continuously supplied from blood limited internal stores. Astrocytes, which interface with neurons vessels, play crucial role coordinating metabolic activity, their dysfunction can have detrimental effects health. This review characterizes major substrates (glucose, lactate, glycogen, ketones lipids) astrocyte health, focusing developments field.

Language: Английский

Citations

4
Drosophila glial system: an approach towards understanding molecular complexity of neurodegenerative diseases DOI

Shweta Shweta,

Khushboo Sharma,

Mallikarjun Shakarad

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Nov. 12, 2024

Language: Английский

Citations

4
Improvement in the prediction power of an astrocyte genome-scale metabolic model using multi-omic data DOI Creative Commons

Andrea Angarita-Rodríguez,

Nicolás Mendoza-Mejía,

Janneth González

et al.

Frontiers in Systems Biology, Journal Year: 2025, Volume and Issue: 4

Published: Jan. 3, 2025

Introduction The availability of large-scale multi-omic data has revolution-ized the study cellular machinery, enabling a systematic understanding biological processes. However, integration these datasets into Genome-Scale Models Metabolism (GEMs) re-mains underexplored. Existing methods often link transcriptome and proteome independently to reaction boundaries, providing models with estimated maximum rates based on individual datasets. This independent approach, however, introduces uncertainties inaccuracies. Methods To address challenges, we applied principal component analysis (PCA)-based approach integrate data. method facilitates reconstruction context-specific grounded in multi-omics data, enhancing their relevance predictive capacity. Results Using this successfully reconstructed an astrocyte GEM improved prediction capabilities compared state-of-the-art available literature. Discussion These advancements underscore potential inte-gration refine metabolic modeling its critical role studying neurodegeneration developing effective therapies.

Language: Английский

Citations

0
Bibliometric insights into astrocytic roles in depression and treatment DOI Creative Commons

Linsun Lin,

Ziyi Guo,

Zhuoyu Ren

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 15, 2025

Depression is a mental disorder that significantly impairs both physical and health. Recent studies have shown reactive astrogliosis gained significant attention for their involvement in the pathophysiology of depression. However, there no bibliometric analysis this research field. This study aims to provide comprehensive overview knowledge structure hotspots regarding role astrocytes mechanisms treatment depression through analysis. The scope literature review encompasses basic clinical research. Publications related from 2014 2023 were searched Web Science Core Collection (WoSCC) database. VOSviewer, CiteSpace, R package "bibliometrix" used conduct From 2023, total 1,502 documents 78 countries on analyzed 169 journals, with most co-cited journals being Journal Neuroscience PNAS. China Medical University was productive institution. identified key authors like Verkhratsky Alexei Baoman Li, major references by Rajkowska Liddelow. Keywords such as "synaptic plasticity," "astrocytes," "neuroinflammation" revealed trends focusing molecular mechanisms, gut microbiota, inflammation. first comprehensively summarize advancements its treatment. Through analysis, we aim enhance understanding significance new perspectives insights future investigations. We hope will facilitate broader integration research, offering novel approaches

Language: Английский

Citations

0
Specialized Established Techniques for Assessing Multiorgan Damages at Different Levels of the Gut-Liver-Brain Axis in Experimental Animal Models of Hepatic Encephalopathy DOI
Ali Sepehrinezhad, Ali Shahbazi

Neuromethods, Journal Year: 2025, Volume and Issue: unknown, P. 259 - 291

Published: Jan. 1, 2025

Language: Английский

Citations

0
Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling DOI Creative Commons
Christina C. Ramelow, Eric B. Dammer,

Hailian Xiao

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Abstract Deep molecular phenotyping of cells at transcriptomic and proteomic levels is an essential first step to understanding cellular contributions development, aging, injury, disease. Since proteome transcriptome level abundances only modestly correlate with each other, complementary profiling both needed. We report a novel method called simultaneous protein RNA –omics (SPARO) capture the cell type-specific simultaneously from in vitro vivo experimental model systems. This leverages ability biotin ligase, TurboID, biotinylate cytosolic proteins including ribosomal RNA-binding proteins, which allows enrichment biotinylated for proteomics as well protein-associated transcriptomics. validated this approach using well-controlled systems verify that proteomes transcriptomes obtained reflect ground truth, bulk transcriptomes. also show effect biological stimulus (e.g., neuroinflammatory activation by lipopolysaccharide) can be faithfully captured. applied obtain native-state two key neural types, astrocytes neurons, thereby validating application SPARO. Next, we used these data interrogate protein-mRNA concordance discordance across providing insights into groups processes exhibit uniform or patterns mRNA-protein discordance.

Language: Английский

Citations

0
Multi-omic Characterization of HIV Effects at Single Cell Level across Human Brain Regions DOI Creative Commons
Junchen Yang, Kriti Agrawal, Jay S. Stanley

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Abstract HIV infection exerts profound and long-lasting neurodegenerative effects on the central nervous system (CNS) that can persist despite antiretroviral therapy (ART). Here, we used single-nucleus multiome sequencing to map transcriptomic epigenetic landscapes of postmortem human brains from 13 healthy individuals 20 with who have a history treatment ART. Our study spanned three distinct regions—the prefrontal cortex, insular ventral striatum—enabling comprehensive exploration region-specific cross-regional perturbations. We found widespread persistent HIV-associated transcriptional alterations across multiple cell types. Detailed analyses microglia revealed state changes marked by immune activation metabolic dysregulation, while integrative multiomic profiling astrocytes identified subpopulations, including reactive subpopulation unique HIV-infected brains. These findings suggest cells people exhibit molecular shifts may underlie ongoing neuroinflammation CNS dysfunction. Furthermore, cell–cell communication uncovered dysregulated pro-inflammatory interactions among glial populations, underscoring multifaceted enduring impact brain milieu. Collectively, our atlas reveals states signatures signaling providing framework for developing targeted therapies neurological

Language: Английский

Citations

0