Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
19(4), P. 833 - 845
Published: Aug. 14, 2023
A
growing
body
of
evidence
suggests
that
the
gut
microbiota
contributes
to
development
neurodegenerative
diseases
via
microbiota-gut-brain
axis.
As
a
contributing
factor,
dysbiosis
always
occurs
in
pathological
changes
diseases,
such
as
Alzheimer's
disease,
Parkinson's
and
amyotrophic
lateral
sclerosis.
High-throughput
sequencing
technology
has
helped
reveal
bidirectional
communication
between
central
nervous
system
enteric
is
facilitated
by
microbiota's
diverse
microorganisms,
for
both
neuroimmune
neuroendocrine
systems.
Here,
we
summarize
bioinformatics
analysis
wet-biology
validation
metagenomics
with
an
emphasis
on
multi-omics
studies
virome.
The
pathogen-associated
signaling
biomarkers
identifying
brain
disorders
potential
therapeutic
targets
are
also
elucidated.
Finally,
discuss
role
diet,
prebiotics,
probiotics,
postbiotics
exercise
interventions
remodeling
microbiome
reducing
symptoms
diseases.
Translational Neurodegeneration,
Journal Year:
2023,
Volume and Issue:
12(1)
Published: May 12, 2023
Abstract
Neurological
conditions,
including
cognitive
impairment
and
Alzheimer’s
disease
(AD),
impose
a
huge
burden
on
society,
affecting
millions
of
people
globally.
In
addition
to
genetic
factors,
recent
studies
indicate
that
environmental
experiential
factors
may
contribute
the
pathogenesis
these
diseases.
Early
life
adversity
(ELA)
has
profound
impact
brain
function
health
later
in
life.
rodent
models,
exposure
ELA
results
specific
deficits
aggravated
AD
pathology.
Extensive
concerns
have
been
raised
regarding
higher
risk
developing
impairments
with
history
ELA.
this
review,
we
scrutinize
findings
from
human
animal
focusing
connection
AD.
These
discoveries
suggest
ELA,
especially
at
early
postnatal
stages,
increases
susceptibility
terms
mechanisms,
could
lead
dysregulation
hypothalamus-pituitary-adrenal
axis,
altered
gut
microbiome,
persistent
inflammation,
oligodendrocyte
dysfunction,
hypomyelination,
aberrant
adult
hippocampal
neurogenesis.
Crosstalks
among
events
synergistically
Additionally,
discuss
several
interventions
alleviate
adverse
consequences
Further
investigation
into
crucial
area
will
help
improve
management
reduce
related
neurological
conditions.
Mechanisms of Ageing and Development,
Journal Year:
2023,
Volume and Issue:
211, P. 111787 - 111787
Published: Feb. 1, 2023
Alzheimer's
disease
(AD)
is
a
neurodegenerative
disorder
that
affects
millions
of
people
worldwide.
Growing
evidence
suggests
the
gut
microbiome
(GM)
plays
pivotal
role
in
pathogenesis
AD
through
microbiota-gut-brain
axis
(MGB).
Alterations
GM
composition
and
diversity
have
been
observed
both
animal
models
human
patients
with
AD.
dysbiosis
has
implicated
increased
intestinal
permeability,
blood-brain
barrier
(BBB)
impairment,
neuroinflammation
development
hallmarks
Further
elucidation
could
pave
way
for
holistic
predictive
methods
determining
risk
progression
disease.
Furthermore,
accumulating
modulation
alleviate
adverse
symptoms
or
serve
as
preventive
measure.
In
addition,
increasing
shows
Type
2
Diabetes
Mellitus
(T2DM)
often
comorbid
AD,
common
alterations
inflammatory
response,
which
chart
GM-related
treatment
interventions
diseases.
We
conclude
by
exploring
therapeutic
potential
alleviating
reducing
risk.
we
also
propose
future
directions
research,
namely
fecal
microbiota
transplantation
(FMT)
precision
medicine.
Advances in Nutrition,
Journal Year:
2023,
Volume and Issue:
14(4), P. 819 - 839
Published: April 17, 2023
Alzheimer's
disease
(AD)
is
a
neurodegenerative
characterized
by
progressive
cognitive
impairment
and
neuroinflammation.
Recent
research
has
revealed
the
crucial
role
of
gut
microbiota
microbial
metabolites
in
modulating
AD.
However,
mechanisms
which
microbiome
affect
brain
function
remain
poorly
understood.
Here,
we
review
literature
on
changes
diversity
composition
patients
with
AD
animal
models
We
also
discuss
latest
progress
understanding
pathways
from
host
or
diet
regulate
By
effects
dietary
components
function,
composition,
metabolites,
examine
potential
for
manipulation
through
intervention
to
delay
progression
Although
it
challenging
translate
our
microbiome-based
approaches
guidelines
clinical
therapies,
these
findings
provide
an
attractive
target
promoting
function.
Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
19(4), P. 833 - 845
Published: Aug. 14, 2023
A
growing
body
of
evidence
suggests
that
the
gut
microbiota
contributes
to
development
neurodegenerative
diseases
via
microbiota-gut-brain
axis.
As
a
contributing
factor,
dysbiosis
always
occurs
in
pathological
changes
diseases,
such
as
Alzheimer's
disease,
Parkinson's
and
amyotrophic
lateral
sclerosis.
High-throughput
sequencing
technology
has
helped
reveal
bidirectional
communication
between
central
nervous
system
enteric
is
facilitated
by
microbiota's
diverse
microorganisms,
for
both
neuroimmune
neuroendocrine
systems.
Here,
we
summarize
bioinformatics
analysis
wet-biology
validation
metagenomics
with
an
emphasis
on
multi-omics
studies
virome.
The
pathogen-associated
signaling
biomarkers
identifying
brain
disorders
potential
therapeutic
targets
are
also
elucidated.
Finally,
discuss
role
diet,
prebiotics,
probiotics,
postbiotics
exercise
interventions
remodeling
microbiome
reducing
symptoms
diseases.
