Biomarkers in Neuropsychiatry,
Journal Year:
2024,
Volume and Issue:
10, P. 100093 - 100093
Published: April 10, 2024
Adverse
childhood
experiences
(ACEs)
are
associated
with
developing
systemic
diseases
and
mental
illnesses,
affecting
multiple
body
systems,
including
those
that
affect
allostasis,
such
as
the
immune,
endocrine,
nervous
systems.
Numerous
different
biomarkers
reflect
biological
manifestations
of
ACEs
across
these
systems
point
to
possible
mechanisms
pathology
following
early
adversity.
Retinal
layer
thickness
values
retinal
microvasculature
parameters,
which
may
central
system
structure
function,
have
scarcely
been
explored
in
relation
life
stress
humans
but
could
potentially
be
valuable
indicators
adversity
sequelae.
Animal
models
using
rodents
demonstrate
is
structural
functional
alterations
retina.
Thus,
given
widespread
impact
several
allostatic
body,
retina
a
part,
evidence
animal
suggesting
relationship
between
alterations,
likely
affected
by
humans.
also
represent
especially
feasible
methods
for
exploring
effects
on
they
can
examined
vivo
optical
coherence
tomography
(OCT),
OCT
angiography
(OCTA),
electroretinography
(ERG),
quick
noninvasive
imaging
electrophysiological
techniques.
Therefore,
future
research
should
focus
what
changes
predict
terms
symptoms,
course,
impairment
negative
physical
health
outcomes.
This
further
our
understanding
pathological
disorders
individuals
at
risk
developing.
Annals of Neurology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
Objective
Despite
the
overwhelming
evidence
for
profound
and
longstanding
effects
of
early‐life
stress
(ELS)
on
inflammation,
brain
structure,
molecular
aging,
its
impact
human
aging
risk
neurodegenerative
disease
is
poorly
understood.
We
examined
ELS
severity
in
interaction
with
age
blood‐based
markers
neuroinflammation
neurodegeneration,
volumes,
cognitive
function
middle‐aged
women.
Methods
recruited
179
women
(aged
30–60
years)
without
exposure
before
onset
puberty.
Using
Simoa
technology,
we
assessed
including
serum
concentrations
glial
fibrillary
acidic
protein
(GFAP)
neurofilament
light
chain
(NfL).
further
obtained
T1‐weighted
T2‐weighted
magnetic
resonance
images
to
assess
volumes
performance
sensitive
early
impairments
associated
development
dementia,
using
Cambridge
Neuropsychological
Automated
Test
Battery.
used
generalized
additive
models
examine
nonlinear
these
outcomes.
Results
Analyses
revealed
significant
NfL
GFAP
concentrations,
total
subcortical
gray
matter
volume
loss,
increased
third
ventricular
volume,
impairment.
Interpretation
These
findings
suggest
that
profoundly
exacerbates
peripheral,
neurostructural,
aging.
Our
results
are
critical
novel
prevention
strategies
target
developmental
mitigate
aging‐related
neurological
diseases.
ANN
NEUROL
2025
Proceedings of the National Academy of Sciences,
Journal Year:
2024,
Volume and Issue:
121(38)
Published: Sept. 9, 2024
Adolescence
is
a
period
of
substantial
social–emotional
development,
accompanied
by
dramatic
changes
to
brain
structure
and
function.
Social
isolation
due
lockdowns
that
were
imposed
because
the
COVID-19
pandemic
had
detrimental
impact
on
adolescent
mental
health,
with
health
females
more
affected
than
males.
We
assessed
focus
sex
differences.
collected
MRI
structural
data
longitudinally
from
adolescents
prior
after
lockdowns.
The
pre-COVID
used
create
normative
model
cortical
thickness
change
age
during
typical
development.
Cortical
values
in
post-COVID
compared
this
model.
analysis
revealed
accelerated
thinning
brain,
which
was
widespread
throughout
greater
magnitude
When
measured
terms
equivalent
years
mean
acceleration
found
be
4.2
y
1.4
Accelerated
maturation
as
result
chronic
stress
or
adversity
development
has
been
well
documented.
These
findings
suggest
lifestyle
disruptions
associated
caused
biology
severe
female
male
brain.
Redox Biology,
Journal Year:
2024,
Volume and Issue:
73, P. 103196 - 103196
Published: May 16, 2024
Hippocampal
neural
stem/progenitor
cells
(NSPCs)
are
highly
vulnerable
to
different
stress
stimuli,
resulting
in
adult
neurogenesis
decline
and
eventual
cognitive
defects.
Our
previous
study
demonstrated
that
NOD-like
receptor
family
pyrin
domain-containing
6
(Nlrp6)
expressed
NSPCs
played
a
critical
role
sustaining
hippocampal
resist
stress-induced
depression,
but
the
underlying
mechnistms
still
unclear.
Here,
we
found
Nlrp6
depletion
led
defects
NSPC
loss
mice.
RNA-sequencing
analysis
of
primary
revealed
deficiency
altered
gene
expression
profiles
mitochondrial
energy
generation
ferroptotic
process.
Upon
siNlrp6
transfection,
as
well
corticosterone
(CORT)
exposure,
downregulation
suppressed
retinoic
acid-inducible
I
(RIG-1)/mitochondrial
antiviral
signaling
proteins
(MAVS)-mediated
autophagy,
drove
death.
More
interesting,
short
chain
fatty
acids
(SCFAs)
upregulated
promoted
RIG-1/MAVS-mediated
mitophagy,
preventing
CORT-induced
ferroptosis.
further
demonstrates
should
be
sensor
for
mitophagy
play
maintain
homeostasis
NSPCs.
These
results
suggests
potential
drug
target
combat
neurodegenerative
diseases
relative
with
chronic
stress.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(9), P. 1978 - 1978
Published: Sept. 2, 2024
Stress
profoundly
affects
physical
and
mental
health,
particularly
when
experienced
early
in
life.
Early-life
stress
(ELS)
encompasses
adverse
childhood
experiences
such
as
abuse,
neglect,
violence,
or
chronic
poverty.
These
stressors
can
induce
long-lasting
changes
brain
structure
function,
impacting
areas
involved
emotion
regulation,
cognition,
response.
Consequently,
individuals
exposed
to
high
levels
of
ELS
are
at
an
increased
risk
for
health
disorders
like
depression,
anxiety,
post-traumatic
disorders,
well
issues,
including
metabolic
cardiovascular
disease,
cancer.
This
review
explores
the
biological
psychological
consequences
early-life
adversity
paradigms
rodents,
maternal
separation
deprivation
limited
bedding
nesting.
The
study
these
experimental
models
have
revealed
that
organism’s
response
is
complex,
involving
genetic
epigenetic
mechanisms,
associated
with
dysregulation
physiological
systems
nervous,
neuroendocrine,
immune
systems,
a
sex-dependent
fashion.
Understanding
impact
crucial
developing
effective
interventions
preventive
strategies
humans
stressful
traumatic
childhood.
Aging and Disease,
Journal Year:
2023,
Volume and Issue:
15(2), P. 698 - 698
Published: Aug. 2, 2023
Cellular
senescence
is
an
irreversible
and
multifaceted
process
inducing
tissue
dysfunction
organismal
aging,
thus
the
clearance
of
senescent
cells
can
prevent
or
delay
onset
aging-related
pathologies.
Herein,
we
developed
augmented
photothermal
therapy
strategy
integrated
with
antibody
against
β2-microglobulin
(aB2MG)
immune
adjuvant
imiquimod
(R837)
to
effectively
accelerate
cell
apoptosis
under
a
near-infrared
light.
With
this
strategy,
designed
CroR@aB2MG
enables
targeting
application
concomitantly,
initiation
subsequently,
finally
realization
protective
effects
senescence.
Our
results
showed
that
photo-induced
heating
effect
caused
quickly
undergo
synchronous
response
accelerated
in
vitro
vivo.
Therefore,
photoactivated
speedy
clearing
may
provide
efficient
way
for
treatment
senescence-related
diseases
by
eliminating
biomaterials.
Neuroscience & Biobehavioral Reviews,
Journal Year:
2024,
Volume and Issue:
162, P. 105724 - 105724
Published: May 16, 2024
Alzheimer's
disease
(AD)
is
prevalent
around
the
world,
yet
our
understanding
of
still
very
limited.
Recent
work
suggests
that
cornerstone
AD
may
include
inflammation
accompanies
it.
Failure
a
normal
pro-inflammatory
immune
response
to
resolve
lead
persistent
central
contributes
unsuccessful
clearance
amyloid-beta
plaques
as
they
form,
neuronal
death,
and
ultimately
cognitive
decline.
Individual
metabolic,
dietary
(lipid)
profiles
can
differentially
regulate
this
inflammatory
process
with
aging,
obesity,
poor
diet,
early
life
stress
other
factors
contributing
greater
risk
developing
AD.
Here,
we
integrate
evidence
for
interface
between
these
factors,
how
contribute
brain
milieu.
In
particular,
discuss
importance
appropriate
polyunsaturated
fatty
acids
(PUFA)
in
diet
metabolism
specialised
pro-resolving
mediators
(SPMs);
raising
possibility
strategies
improve
outlook.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 161 - 161
Published: Jan. 22, 2025
Early
life
adversity
(ELA)
has
long
been
recognized
to
negatively
impact
a
variety
of
health
outcomes,
with
increasingly
long-term
implications
for
neurocognitive
function.
ELA
may
affect
the
brain
through
multiple
mechanisms,
including
chronic
inflammation.
One
potential
moderator
pathway
from
neuroinflammation
cognitive
dysfunction
is
sex.
leave
females
potentially
even
more
vulnerable
impairment
in
later
life.
This
review
discusses
influence
on
function
across
much
lifespan,
how
inflammation
implicated
this
process,
and
current
state
knowledge
regarding
sex
differences
these
relationships.
We
conclude
discussion
unanswered
questions
suggestions
future
research,
incorporation
genetic
data.
