Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 294 - 294

Published: Jan. 20, 2023

Gut microbes and their metabolites are actively involved in the development regulation of host immunity, which can influence disease susceptibility. Herein, we review most recent research advancements gut microbiota–immune axis. We discuss detail how microbiota is a tipping point for neonatal immune as indicated by newly uncovered phenomenon, such maternal imprinting, utero intestinal metabolome, weaning reaction. describe shapes both innate adaptive immunity with emphasis on short-chain fatty acids secondary bile acids. also comprehensively delineate disruption axis results immune-mediated diseases, gastrointestinal infections, inflammatory bowel cardiometabolic disorders (e.g., cardiovascular diabetes, hypertension), autoimmunity rheumatoid arthritis), hypersensitivity asthma allergies), psychological anxiety), cancer colorectal hepatic). further encompass role fecal transplantation, probiotics, prebiotics, dietary polyphenols reshaping therapeutic potential. Continuing, examine modulates therapies, including checkpoint inhibitors, JAK anti-TNF therapies. lastly mention current challenges metagenomics, germ-free models, recapitulation to achieve fundamental understanding regulates immunity. Altogether, this proposes improving immunotherapy efficacy from perspective microbiome-targeted interventions.

Language: Английский

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Decoding the neurocircuitry of gut feelings: Region-specific microbiome-mediated brain alterations

Neurobiology of Disease, Journal Year: 2023, Volume and Issue: 179, P. 106033 - 106033

Published: Feb. 8, 2023

Research in the last decade has unveiled a crucial role for trillions of microorganisms that reside gut influencing host neurodevelopment across lifespan via microbiota-gut-brain axis. Studies have linked alterations composition, complexity, and diversity microbiota to changes behaviour including abnormal social interactions, cognitive deficits, anxiety- depressive-like phenotypes. Moreover, been with neurodevelopmental, neuropsychiatric, neurodegenerative disorders. Interestingly, there appears be specific brain regions governing neurocircuitry driving higher function are susceptible influence from manipulations microbiome. This review will aim elucidate region-specific effects mediated by microbiota, focus on translational animal models some existing human neuroimaging data. Compelling preclinical evidence suggests disruption normal signalling can detrimental prefrontal cortex, amygdala, hippocampus, hypothalamus, striatum. Furthermore, studies mediating functional connectivity structure traced back neurocognition behavioural output. Understanding these microbiota-mediated aid identifying unique therapeutic targets treating neurological disorders associated regions.

Language: Английский

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TGR5 deficiency-induced anxiety and depression-like behaviors: The role of gut microbiota dysbiosis

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 344, P. 219 - 232

Published: Oct. 13, 2023

Language: Английский

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Pro-inflammatory cytokines in stress-induced depression: Novel insights into mechanisms and promising therapeutic strategies

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 131, P. 110931 - 110931

Published: Jan. 2, 2024

Language: Английский

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From Birth to Weaning: A Window of Opportunity for Microbiota

Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 272 - 272

Published: Jan. 17, 2024

(1) Background: The first 1000 days of life constitute a critical window opportunity for microbiota development. Nutrients play crucial role in enriching and diversifying the microbiota, derived not only from solid food but also maternal dietary patterns during gestation. (2) Methods: We conducted comprehensive literature review using PubMed database, covering eleven years (2013–2023). included English-language reviews, original research papers, meta-analyses, while excluding case reports letters. (3) Results: Consensus emphasizes that our interaction with multitude microorganisms begins intrauterine environment continues throughout lives. existing data suggest early nutritional education programs, initiated pregnancy guiding infant diets development, may influence shaping gut promoting long-term health. (4) Conclusions: Further is necessary coming to assess potential interventions models aimed at modulating pediatric especially vulnerable populations such as premature newborns.

Language: Английский

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The Potential Impact of the Gut Microbiota on Neonatal Brain Development and Adverse Health Outcomes

Children, Journal Year: 2024, Volume and Issue: 11(5), P. 552 - 552

Published: May 5, 2024

Over the past decade, microbiome research has significantly expanded in both scope and volume, leading to development of new models treatments targeting gut–brain axis mitigate effects various disorders. Related suggests that interventions during critical period from birth three years old may yield greatest benefits. Investigating substantial link between gut brain this crucial developmental phase raises fundamental issues about role microorganisms human health development. This underscores importance focusing on prevention rather than treatment neurodevelopmental neuropsychiatric The present review examines microbiota age 3, with a particular focus its potential relationship neurodevelopment. emphasizes immunological mechanisms underlying relationship. Additionally, study investigates impact cognitive neurobehavioral such as anxiety autism. Importantly, it highlights need integrate mechanistic studies animal epidemiological across diverse cultures better understand healthy early life implications dysbiosis. Furthermore, summarizes factors contributing transmission microbiome-targeted therapies their Recent environmental toxins known neurodevelopment are also reviewed, exploring whether or modulate these effects.

Language: Английский

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Stress and depression-associated shifts in gut microbiota: A pilot study of human pregnancy

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 36, P. 100730 - 100730

Published: Jan. 26, 2024

Psychosocial stress and mood-related disorders, such as depression, are prevalent vulnerability to these conditions is heightened during pregnancy. induces consequences via several mechanisms including the gut microbiota-brain axis associated signaling pathways. Previous preclinical work indicates that prenatal alters maternal microbial composition impairs offspring development. Importantly, although fecal vaginal microenvironments undergo alterations across pregnancy, we lack consensus regarding which shifts adaptive or maladaptive in presence of depression. Clinical studies interrogating relationships have identified unique taxa but been limited study design.

Language: Английский

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Maternal Pre- and Postnatal Stress and Maternal and Infant Gut Microbiota Features.

Psychoneuroendocrinology, Journal Year: 2025, Volume and Issue: 172, P. 107273 - 107273

Published: Jan. 2, 2025

Maternal stress can have short and long term adverse (mental) health effects for the mother her child. Previous evidence suggests that gut microbiota may be a potential mediator moderator of via various pathways. This study explored maternal trajectory during pregnancy as well association between pre- postnatal features infant after pregnancy. In line with previous research, we hypothesized would positively related to volatility infants highly stressed mothers show relative increase in Proteobacteria decrease Bifidobacterium. We collected stool samples at 18 32 weeks 8 months postpartum. Infant stools were obtained 2, 6 12 All analyzed using shotgun metagenome sequencing. also several measures (self-reported depression, anxiety, stress, hair cortisol cortisone), most same time points samples. Our data indicated does not undergo drastic changes from second third trimester but postpartum differs significantly prenatal microbiota. Furthermore, identified associations different including positive negative alpha diversity, beta diversity individual microbial phyla species abundances. Also, composite score, perceived score log-ratio cortisone all associated volatility. provides is both Collectively, this studies indicate uniformly associate features. Instead, are point specific. Regarding volatility, consistently found warrants future research investigating link more depth.

Language: Английский

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The impact of perinatal maternal stress on the maternal and infant gut and human milk microbiomes: A scoping review

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0318237 - e0318237

Published: Feb. 28, 2025

Background Perinatal maternal stress, which includes both psychological and physiological stress experienced by healthy women during pregnancy the postpartum period, is becoming increasingly prevalent. Infant early exposure to adverse environments such as perinatal has been shown increase long-term risk metabolic, immunologic neurobehavioral disorders. Evidence suggests that human microbiome facilitates transmission of factors infants via vaginal, gut, milk microbiomes. The colonization aberrant microorganisms in mother’s microbiome, influenced microbiome-brain-gut axis, may be transferred a critical developmental period. This transfer predispose more inflammatory-prone associated with dysregulated metabolic process leading health outcomes. Given prevalence potential impact on infant health, no systematic mapping or review data date, aim this scoping gather evidence relationship between milk, maternal, gut Methods an exploratory review, guided Joanna Briggs Institute’s methodology along use Prisma Scr reporting guideline. A comprehensive search was conducted using following databases, CINAHL Complete; MEDLINE; PsycINFO, Web Science Scopus protocol registered Open Framework DOI 10.17605/OSF.IO/5SRMV. Results After screening 1145 papers there were 7 paper met inclusion criteria. Statistically significant associations found five studies identify higher abundance potentially pathogenic bacteria Erwinia, Serratia, T mayombie, Bacteroides lower levels linked beneficial Lactococcus, Lactobacillus, Akkermansia. However, one study presents conflicting results where it reported bacteria. Conclusion does have alteration diversity influential however, can affect colonisation different ways. These bacterial changes capacity influence long term disease. analyses collection tools methods, offers reasons for these findings well suggestions future research.

Language: Английский

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Innate immune system signaling and intestinal dendritic cells migration to the brain underlie behavioral changes after microbial colonization in adult mice

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Accumulating evidence suggests the microbiota is a key factor in Disorders of Gut-Brain Interaction (DGBI), by affecting host immune and neural systems. However, underlying mechanisms remain elusive due to their complexity clinical heterogeneity patients with DGBIs. We aimed identify neuroimmune pathways that are critical microbiota-gut-brain communication during de novo gut colonization. employed combination gnotobiotic state-of-the-art microbial tools, behavioral analysis, pharmacological approaches. Germ-free wild type, TLR signaling-deficient MyD88-/- Ticam1-/- lymphocyte-deficient SCID mice were studied before after colonization specific pathogen-free microbiota, Altered Schaedler Flora, E. coli or S. typhimurium (permanent transient colonizers). agonists antagonists, CCR7 antagonist immunomodulators used study pathways. assessed brain c-Fos, brain-derived neurotrophic factor, dendritic glial cells immunofluorescence, expression genes NanoString performed proteomics. Bacterial monocolonization, conventionalization administration products germ-free altered mouse behavior similarly, acting through Toll-like receptor nucleotide-binding oligomerization domain signaling. The process required CD11b+CD11c+CD103+ cell activation migration into brain. change did not require continued presence bacteria was associated multiple neuro-immune networks Changes plasticity occur rapidly upon initial involve innate signaling brain, mediated migration. results new target therapeutic potential for DGBIs developing context increased blood-brain barrier permeability.

Language: Английский

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