International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
24(1), P. 350 - 350
Published: Dec. 26, 2022
Major
depressive
disorder
(MDD)
is
widely
accepted
as
having
a
heterogenous
pathophysiology
involving
complex
mixture
of
systemic
and
CNS
processes.
A
developmental
etiology
coupled
to
genetic
epigenetic
risk
factors
well
lifestyle
social
process
influences
add
further
the
complexity.
Consequently,
antidepressant
treatment
generally
regarded
open
improvement,
undoubtedly
consequence
inappropriately
targeted
pathophysiological
This
article
reviews
diverse
array
processes
linked
MDD,
integrates
these
within
perspective
that
emphasizes
alterations
in
mitochondrial
function,
both
centrally
systemically.
It
proposed
long-standing
association
MDD
with
suppressed
serotonin
availability
reflective
role
precursor
for
melatonergic
pathway.
Astrocytes,
astrocyte
pathway,
are
highlighted
crucial
hubs
integration
wide
biological
underpinnings
including
gut
dysbiosis
permeability,
stressors,
which
can
act
suppress
capacity
mitochondria
upregulate
consequences
oxidant-induced
changes
patterned
microRNAs
subsequent
gene
responses.
placed
development
context,
how
processes,
such
discrimination,
physiologically
regulate
susceptibility
MDD.
Future
research
directions
implications
derived
from
this.
Developmental Psychology,
Journal Year:
2024,
Volume and Issue:
60(9), P. 1620 - 1638
Published: Feb. 15, 2024
Given
prior
literature
focused
on
the
Developmental
Origins
of
Health
and
Disease
framework,
there
is
strong
rationale
to
hypothesize
that
reducing
depression
in
prenatal
period
will
cause
improvements
offspring
cardiometabolic
health.
The
current
review
outlines
evidence
associated
with
risk
health
behaviors.
We
these
associations
humans
nonhuman
animals
at
multiple
developmental
periods,
from
(maternal
preeclampsia,
gestational
diabetes),
neonatal
(preterm
birth,
small
size
birth),
infancy
(rapid
weight
gain),
childhood
adolescence
(high
blood
pressure,
impaired
glucose-insulin
homeostasis,
unfavorable
lipid
profiles,
abdominal
obesity),
into
adulthood
(diabetes,
cardiovascular
disease).
In
addition
outcomes,
we
focus
behaviors
risk,
such
as
child
eating
behaviors,
diet,
physical
activity,
sleep
Our
focuses
(e.g.,
emotional
eating,
preference
for
highly
palatable
foods,
short
duration)
parenting
pressuring
eat,
modeling
behaviors).
These
changes
may
be
detected
before
which
allow
early
identification
prevention
children
poor
adult
outcomes.
also
discuss
methods
ongoing
Care
Project,
a
randomized
clinical
trial
test
whether
maternal
improves
offspring's
preschool.
goal
this
Project
are
inform
future
research,
interventions,
policies
support
mental
(PsycInfo
Database
Record
(c)
2024
APA,
all
rights
reserved).
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(6), P. e0304787 - e0304787
Published: June 5, 2024
Objective
The
objective
of
this
scoping
review
is
to
the
research
evidence
regarding
impact
perinatal
maternal
stress
on
and
infant
gut
human
milk
microbiomes.
Introduction
Perinatal
which
refers
psychological
experienced
by
individuals
during
pregnancy
postpartum
period
emerging
as
a
public
health
concern.
Early
exposure
infants
can
potentially
lead
metabolic,
immune,
neurobehavioral
disorders
that
extend
into
adulthood.
role
microbiome
in
microbiome-gut-brain
axis
mechanism
transfer
has
been
previously
reported.
A
colonised
aberrant
microbiota
from
mother
proposed
predispose
pro-
inflammatory
with
dysregulated
metabolic
process
thereby
initiating
early
risk
chronic
diseases.
interplay
its
relationship
requires
further
systematic
examination
literature.
Inclusion
criteria
This
an
exploratory
mapping
will
focus
population
mothers
exploration
key
concepts
context
period.
It
post-natal
up
6
months
who
are
exclusively
breastfed.
Methods
study
be
guided
Joanna
Briggs
Institute’s
(JBI)
methodology
for
reviews
along
use
Prisma
Scr
reporting
guideline.
comprehensive
search
conducted
using
following
databases,
CINAHL
Complete;
MEDLINE;
PsycINFO,
Web
Science
Scopus.
strategy
pre-defined
inclusion
exclusion
used
retrieve
peer
reviewed
data
published
English
2014
present.
Screening
involve
three-step
screening
tool
checklists.
Results
presented
tabular
narrative
summaries,
covering
thematic
their
relationships.
protocol
registered
Open
Framework
DOI
10.17605/OSF.IO/5SRMV
.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
24(1), P. 350 - 350
Published: Dec. 26, 2022
Major
depressive
disorder
(MDD)
is
widely
accepted
as
having
a
heterogenous
pathophysiology
involving
complex
mixture
of
systemic
and
CNS
processes.
A
developmental
etiology
coupled
to
genetic
epigenetic
risk
factors
well
lifestyle
social
process
influences
add
further
the
complexity.
Consequently,
antidepressant
treatment
generally
regarded
open
improvement,
undoubtedly
consequence
inappropriately
targeted
pathophysiological
This
article
reviews
diverse
array
processes
linked
MDD,
integrates
these
within
perspective
that
emphasizes
alterations
in
mitochondrial
function,
both
centrally
systemically.
It
proposed
long-standing
association
MDD
with
suppressed
serotonin
availability
reflective
role
precursor
for
melatonergic
pathway.
Astrocytes,
astrocyte
pathway,
are
highlighted
crucial
hubs
integration
wide
biological
underpinnings
including
gut
dysbiosis
permeability,
stressors,
which
can
act
suppress
capacity
mitochondria
upregulate
consequences
oxidant-induced
changes
patterned
microRNAs
subsequent
gene
responses.
placed
development
context,
how
processes,
such
discrimination,
physiologically
regulate
susceptibility
MDD.
Future
research
directions
implications
derived
from
this.
