Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms DOI Creative Commons
Abbas F. Almulla, Michaël Maes, Bo Zhou

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Autoimmune responses contribute to the pathophysiology of Long COVID, affective symptoms and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). To examine whether its accompanying CFS are associated with immunoglobulin (Ig)A/IgM/IgG directed at neuronal proteins including myelin basic protein (MBP), oligodendrocyte glycoprotein (MOG), synapsin, α + β-tubulin, neurofilament (NFP), cerebellar protein-2 (CP2), blood-brain-barrier-brain-damage (BBD) claudin-5 S100B. IgA/IgM/IgG above proteins, human herpes virus-6 (HHV-6) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were measured in 90 COVID patients healthy controls, while C-reactive (CRP), advanced oxidation products (AOPP) association ratings additionally assessed a subgroup thereof. is significant increases IgG tubulin (IgG-tubulin), MBP, MOG synapsin; IgM-MBP, MOG, CP2, synapsin BBD; IgA-CP2 synapsin. IgM-SARS-CoV-2 IgM-HHV-6 antibody titers significantly correlated IgA/IgG/IgM-tubulin -CP2, IgG/IgM-BBD, IgM-MOG, IgA/IgM-NFP, IgG/IgM-synapsin. Binary logistic regression analysis shows that IgM-MBP IgG-MBP best predictors COVID. Multiple IgG-MOG, CRP AOPP explain together 41.7 % variance severity CFS. Neural network IgM-synapsin, IgA-MBP, IgA-synapsin, IgA-CP2, most important due predictive accuracy r = 0.801. Brain-targeted autoimmunity contributes pathogenesis physio-affective phenome.

Language: Английский

Neurobiology and systems biology of stress resilience DOI
Raffaël Kalisch, Scott J. Russo,

Marianne B. Müller

et al.

Physiological Reviews, Journal Year: 2024, Volume and Issue: 104(3), P. 1205 - 1263

Published: March 14, 2024

Stress resilience is the phenomenon that some people maintain their mental health despite exposure to adversity or show only temporary impairments followed by quick recovery. Resilience research attempts unravel factors and mechanisms make possible harness its insights for development of preventative interventions in individuals at risk acquiring stress-related dysfunctions. Biological has been lagging behind psychological social sciences but seen a massive surge recent years. At same time, progress this field hampered methodological challenges related finding suitable operationalizations study designs, replicating findings, modeling animals. We embed review behavioral, neuroimaging, neurobiological, systems biological findings adults critical methods discussion. find preliminary evidence hippocampus-based pattern separation prefrontal-based cognitive control functions protect against pathological fears aftermath singular, event-type stressors [as found fear-related disorders, including simpler forms posttraumatic stress disorder (PTSD)] facilitating perception safety. Reward system-based pursuit savoring positive reinforcers appear more generalized dysfunctions anxious-depressive spectrum resulting from severe longer-lasting (as depression, comorbid anxiety, PTSD). Links between preserved functioning these neural under neuroplasticity, immunoregulation, gut microbiome composition, integrity barrier blood-brain are beginning emerge. On basis, avenues pointed out.

Language: Английский

Citations

26
Increased atherogenicity in mood disorders: a systematic review, meta-analysis and meta-regression DOI
Ketsupar Jirakran, Abbas F. Almulla,

Thapanee Jaipinta

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 169, P. 106005 - 106005

Published: Jan. 8, 2025

Language: Английский

Citations

2
Adverse childhood experiences and recent negative events are associated with activated immune and growth factor pathways, the phenome of first episode major depression and suicidal behaviors DOI
Abbas F. Almulla, Ali Abbas Abo Algon,

Michael Maes

et al.

Psychiatry Research, Journal Year: 2024, Volume and Issue: 334, P. 115812 - 115812

Published: Feb. 29, 2024

Language: Английский

Citations

11
T helper-1 activation via interleukin-16 is a key phenomenon in the acute phase of severe, first-episode major depressive disorder and suicidal behaviors DOI Creative Commons
Abbas F. Almulla, Ali Abbas Abo Algon, Chavit Tunvirachaisakul

et al.

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 64, P. 171 - 181

Published: Nov. 13, 2023

Immune-inflammatory pathways in major depressive disorder are confined to the dysmood (MDMD) phenotype (Maes et al., 2022). No studies have addressed immune profile of first episode MDMD (FE-MDMD).

Language: Английский

Citations

21
Immune activation and immune-associated neurotoxicity in Long-COVID: A systematic review and meta-analysis of 103 studies comprising 58 cytokines/chemokines/growth factors DOI
Abbas F. Almulla,

Yanin Thipakorn,

Bo Zhou

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 122, P. 75 - 94

Published: Aug. 9, 2024

Language: Английский

Citations

7
Advances of curcumin in nervous system diseases: the effect of regulating oxidative stress and clinical studies DOI Creative Commons
Yuxun Wei, Hong Li, Yue Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 1, 2024

In recent years, researchers have highly observed that neurological disorders (NSDs) with the aging of population are a global health burden whose prevalence is increasing every year. Previous evidence suggested occurrence correlated predisposing factors such as inflammation, aging, and injury. Particularly, neuronal cells susceptible to oxidative stress, leading lesions caused by high oxygen-consuming properties. Oxidative stress (OS) state peroxidation, which occurs result disruption balance between oxidizing antioxidizing substances. The intermediates free radicals, hydrogen peroxide (H

Language: Английский

Citations

7
Assessing causality between chronic obstructive pulmonary disease with depression: A bidirectional Mendelian randomization study DOI Creative Commons
Ang Liu,

Ping-Yang Hong,

Bin Su

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 351, P. 782 - 789

Published: Feb. 8, 2024

Our investigation utilized a two-sample Mendelian randomization approach to explore the ambiguous bidirectional relationship between Chronic Obstructive Pulmonary Disease (COPD) and depression, furthering insights from existing observational studies. In this study, we conducted using genome-wide association studies (GWAS) datasets. We initially analyzed depression data Psychiatric Genomics Consortium UK Biobank (n = 500,199), alongside COPD FinnGen 329,552). The second phase involved comparing 372,472) with 361,194). analysis employs various methods guarantee comprehensive rigorous investigation. initial analytic utilizing inverse variance weighted (IVW) method, does not significantly contribute incidence of (IVW odds ratio (OR) 0.989, 95 % confidence interval (CI) 0.895 1.092, P 0.824). Conversely, suggested statistically significant where may precipitate development COPD, notable increase in risk OR 1.421, CI 1.149 1.756, 0.001). Subsequent validation through second-step reinforced hypothesis that elevates likelihood onset 1.002, 1.0003 1.0046, 0.028). analysis, determined escalate depression. our suggests elevate developing COPD. This insight underscores importance enhancing prevention, screening, treatment strategies for individuals

Language: Английский

Citations

6
Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms DOI Creative Commons
Abbas F. Almulla, Michaël Maes, Bo Zhou

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 5, 2023

Abstract Background Autoimmune responses contribute to the pathophysiology of Long COVID, affective symptoms and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Objectives To examine whether its accompanying CFS are associated with immunoglobulin (Ig)A/IgM/IgG directed at neuronal proteins including myelin basic protein (MBP), oligodendrocyte glycoprotein (MOG), synapsin, α+β-tubulin, neurofilament (NFP), cerebellar protein-2 (CP2), blood-brain-barrier-brain-damage (BBD) claudin-5 S100B. Methods IgA / IgM/IgG above proteins, human herpes virus-6 (HHV-6) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were measured in 90 COVID patients healthy controls, while C-reactive (CRP), advanced oxidation products (AOPP) association ratings additionally assessed a subgroup thereof. Results is significant increases IgG tubulin (IgG-tubulin), MBP, MOG synapsin; IgM-MBP, MOG, CP2, synapsin BBD; IgA-CP2 synapsin. IgM-SARS-CoV-2 IgM-HHV-6 antibody titers significantly correlated IgA/IgG/IgM-tubulin -CP2, IgG/IgM-BBD, IgM-MOG, IgA/IgM-NFP, IgG/IgM-synapsin. Binary logistic regression analysis shows that IgM-MBP IgG-MBP best predictors COVID. Multiple IgG-MOG, CRP AOPP explain together 41.7% variance severity CFS. Neural network IgM-synapsin, IgA-MBP, IgA-synapsin, IgA-CP2, most important due predictive accuracy r=0.801. Conclusion Brain-targeted autoimmunity contributes pathogenesis physio-affective phenome.

Language: Английский

Citations

12
Ferroptosis, pathogenesis and therapy in AS co-depression disease DOI Creative Commons

Yulong Zhao,

Peng Ren,

Qiang Luo

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

Atherosclerosis (AS)-related cardiovascular disease and depression are often comorbid, with patients facing an increased risk of depression, which worsens AS. Both diseases characterized by oxidative stress lipid metabolism disorders. Ferroptosis, a form cell death iron overload harmful peroxide accumulation, is found in various diseases, including AS depression. Consistent the deposition peroxidation (LPO) that characterize ferroptosis mechanism, disturbances also crucial pathogenic mechanisms The comorbid complex, posing challenges for clinical treatment. Chinese herbs hold significant potential owing to their multi-target pharmacological effects. Therefore, this review aims investigate overload, LPO, across types, shared pathogenesis ferroptosis, research on herbal medicine targeting treatment anti-AS co-depression. This provides comprehensive understanding co-depression from perspective ferroptosis.

Language: Английский

Citations

0
Key factors underpinning neuroimmune-metabolic-oxidative (NIMETOX) major depression in outpatients: paraoxonase 1 activity, reverse cholesterol transport, increased atherogenicity, protein oxidation, and differently expressed cytokine networks. DOI Creative Commons
Michaël Maes, Ketsupar Jirakran, Laura de Oliveira Semeão

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Background Major depressive disorder (MDD) is associated with neuro-immune – metabolic oxidative (NIMETOX) pathways. Aims To examine the connections among NIMETOX pathways in outpatient MDD (OMDD) and without syndrome (MetS); to determine prevalence of aberrations a cohort OMDD patients. Methods We included 67 healthy controls 66 patients we assessed various Results successfully identified subgroup individuals pathways, including diminished lecithin-cholesterol acyltransferase (LCAT), paraoxonase 1 (PON1) activity, reverse cholesterol transport (RCT) activities, elevated atherogenicity, differentially expressed immune networks, advanced oxidation protein products (AOPP). A large part variance (around 44%) atherogenicity indices was AOPP, fasting blood glucose (FBG), PON1 activation. LCAT activity positively correlated negatively FBG, AOPP RCT related R/R 192 genotype FBG larger overall severity (50.4%), suicidal behaviors (27.7%), neuroticism (42.1%) adverse childhood experiences immune-related neurotoxicity, insulin, inversely neuroprotection. Conclusions Many (78.8%) show The features OMDD, illness, neuroticism, behaviors, are caused by intertwined that may exert additional effects depending on whether MetS present or not.

Language: Английский

Citations

0