The Transmitter, Journal Year: 2023, Volume and Issue: unknown
Published: Jan. 1, 2023
Language: Английский
Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(4), P. 222 - 247
Published: Feb. 14, 2024
Crosstalk between gut and brain has long been appreciated in health disease, the microbiota is a key player communication these two distant organs. Yet, mechanisms through which influences development function of gut–brain axis remain largely unknown. Barriers present are specialized cellular interfaces that maintain strict homeostasis different compartments across this axis. These barriers include epithelial barrier, blood–brain barrier blood–cerebrospinal fluid barrier. ideally positioned to receive communicate microbial signals constituting gateway for gut–microbiota–brain communication. In Review, we focus on how modulation by can constitute an important channel Moreover, malfunction upon alterations composition could form basis various conditions, including often comorbid neurological gastrointestinal disorders. Thus, should unravelling molecular move from simplistic framing as 'leaky gut'. A mechanistic understanding barriers, especially during critical windows development, be aetiology The modulator This Review provides overview examines role disease.
Language: Английский
Citations
92
Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(8), P. 1454 - 1478
Published: Aug. 22, 2024
Language: Английский
Citations
36
Cell Reports Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 101982 - 101982
Published: March 1, 2025
Language: Английский
Citations
3
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: July 8, 2024
Abstract Melatonin ( N ‐acetyl‐5‐methoxytryptamine) is reported to improve mood disorders in perimenopausal women and gut microbiome composition altered during menopausal period. The possible role of the treatment effect melatonin on depression remains unknown. Here, it shown that reverses microbiota dysbiosis depressive‐like behaviors ovariectomy (OVX) operated mice. This prevented by antibiotic cocktails (ABX) treatment. Transferring harvested from adolescent female mice OVX‐operated sufficient ameliorate behaviors. Conversely, transplantation or melatonin‐treated naïve recipient exhibits similar phenotypes donors. colonization Alistipes Inops , which abundant mice, confers with Further investigation indicates expansion induced OVX leads degradation intestinal tryptophan, destroys systemic tryptophan availability. supplementation restores metabolic suppressing growth ameliorates These results highlight previously unrecognized modulation OVX‐induced behavioral suggest application inhibit may serve as a potential strategy for preventing depressive symptoms.
Language: Английский
Citations
6
Food Research International, Journal Year: 2024, Volume and Issue: 197, P. 115212 - 115212
Published: Oct. 20, 2024
Language: Английский
Citations
6
Alcohol Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 21, 2025
Ethanol metabolism is intimately linked with the physiological and behavioral aspects of ethanol consumption. mainly oxidized by alcohol dehydrogenase (ADH) to acetaldehyde further acetate via aldehyde dehydrogenases (ALDHs). Understanding how its metabolites work together initiate drive continued consumption crucial for identifying interventions use disorder (AUD). Therefore, goal our study was determine ADH1, which peripherally expressed metabolizes >90% ingested ethanol, modulates metabolite distribution downstream behaviors. in drinking-in-the-dark (DID) two-bottle choice (2BC) drinking paradigms, concentrations, lickometry were assessed after ADH1 inhibition and/or Adh1-knockout (Adh1 KO) mice. We found that Adh1 KO mice both sexes exhibited decreased preference compared wild-type (WT) DID 2BC. inhibitor fomepizole (4-MP) also significantly normal sweetened studies. Measurement revealed increased at 1 h but not 15 min, peripheral slightly timepoints, ethanol-induced increases abolished administration controls. Similarly, accumulation as a function 2-fold higher or 4-MP-treated then used this perturbation affects microstructure. consume most their first 30 like WT mice, display altered temporal shifts behaviors do form bout structures, resulting lower Our demonstrates ADH1-mediated key determinant consumption, highlighting fundamental knowledge gap regarding
Language: Английский
Citations
0
Journal of Neuroimmunology, Journal Year: 2025, Volume and Issue: unknown, P. 578609 - 578609
Published: April 1, 2025
Language: Английский
Citations
0
Food Chemistry X, Journal Year: 2024, Volume and Issue: 23, P. 101610 - 101610
Published: July 3, 2024
Dietary fiber targets the regulation of intestinal flora and thus affects host health, however, complex relationship between these factors lacks direct evidence. In this study, regulatory effects Konjac glucomannan (KGM) on key metabolites were examined by using
Language: Английский
Citations
3
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
Abstract Background Ethanol metabolism is intimately linked with the physiological and behavioral aspects of ethanol consumption. mainly oxidized by alcohol dehydrogenase (ADH) to acetaldehyde further acetate via aldehyde dehydrogenases (ALDHs). Understanding how its metabolites work together initiate drive continued consumption crucial for identifying interventions use disorder (AUD). Therefore, goal our study was determine ADH1, which peripherally-expressed metabolizes >90% ingested ethanol, modulates metabolite distribution downstream behaviors. Methods in drinking-in-the-dark (DID) two-bottle choice (2BC) drinking paradigms, concentrations, lickometry were assessed after ADH1 inhibition and/or Adh1 -knockout ( KO) mice. Results We found that KO mice both sexes exhibited decreased preference compared wild-type (WT) DID 2BC. inhibitor fomepizole (4-MP) also significantly normal sweetened studies. Measurement revealed increased at 1h but not 15 min, peripheral slightly time points, ethanol-induced increases abolished administration controls. Similarly, accumulation as a function 2-fold higher or 4-MP treated then used this perturbation affects microstructure. consume most their first 30 min like WT display altered temporal shifts behaviors do form bout structures, resulting lower Conclusions Our demonstrates ADH1-mediated key determinant consumption, highlighting fundamental knowledge gap around
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Neurodevelopmental disorders result from interactions between genetic predisposition and environmental risk factors, with infancy being the most vulnerable period. We designed a longitudinal study to determine how short-term antibiotic exposure during early postnatal life impacts gut microbiome, neurodevelopment, behavior, whether these alterations were exacerbated by neurodevelopmental disorder-associated 16p11.2 microdeletion (16pDel) mutation. The cephalosporin antibiotic, cefdinir, broadly altered microbiome acutely, persistent reductions in several Lachnospiraceae genera despite overall recovery. These preceded long-term behavioral changes, including reduced juvenile sociability, compromised assessment, deficits associative learning. Remarkably, only cefdinir-exposed 16pDel mice had changes hippocampal stem cell proliferation, subsequent adolescent numbers, gene expression compared other groups, demonstrating that can modulate effects of early-life on neurodevelopment. may be mediated gastrointestinal disturbances, as males increased intestinal permeability shifted metabolite profiles arginine biosynthesis glycerophospholipid metabolism. Taken together, this highlights microbial affect behavior reveals influences antibiotic-induced development. Further, insights identify metabolic mechanisms potential targets for intervention raise concerns regarding use infancy.
Language: Английский
Citations
0